CAS No.: 179474-85-2
Prucalopride succinate/琥珀酸普芦卡必利 Catalog No. CSN15934
Synonyms: R-108512;R-093877;R-93877
Prucalopride Succinate is a selective and high-affinity 5-HT4 receptor agonist with enterokinetic activities.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
靶点 5-HT Receptor 4B
pKi:8.15-HT Receptor 4A
pKi:8.6- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01870674 Healthy Phase 1 Completed - Korea, Republic of ... more >> Inje Busan Paik hospital Busan, Korea, Republic of, 614-735 Collapse << NCT03279341 Chronic Constipation Phase 4 Completed - Belgium ... more >> TARGID Leuven, Belgium, 3000 Collapse << NCT02047045 Constipation Not Applicable Completed - - - 更多
- 参考文献
- [1] Priem E, Van Colen I, et al. The facilitating effect of prucalopride on cholinergic neurotransmission in pig gastric circular muscle is regulated by phosphodiesterase 4. Neuropharmacology. 2012 Apr;62(5-6):2126-35.
- [2] Briejer MR, Bosmans JP, et al. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83.
- [3] Briejer MR, Bosmans JP, Van Daele P, Jurzak M, Heylen L, Leysen JE, Prins NH, Schuurkes JA. The in vitro pharmacological profile of prucalopride, a novel enterokinetic compound. Eur J Pharmacol. 2001 Jun 29;423(1):71-83. doi: 10.1016/s0014-2999(01)01087-1. PMID: 11438309.
- [4] Johnson DE, Drummond E, Grimwood S, Sawant-Basak A, Miller E, Tseng E, McDowell LL, Vanase-Frawley MA, Fisher KE, Rubitski DM, Stutzman-Engwall KJ, Nelson RT, Horner WE, Gorczyca RR, Hajos M, Siok CJ. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. J Pharmacol Exp Ther. 2012 Jun;341(3):681-91. doi: 10.1124/jpet.112.192351. Epub 2012 Mar 9. PMID: 22408061.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 179474-85-2 | 储存条件 |
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| 分子式 | C22H32ClN3O7 | 运输 | 蓝冰 | |||||||
| 分子量 | 485.96 | 别名 | R-108512;R-093877;R-93877;Prucalopride Succinate;Resolor;Resotran;Motegrity;琥珀酸普芦卡必利 | |||||||
| 溶解度 |
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动物实验配方 |
