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CAS No.: 50-34-0

Propantheline bromide/溴丙胺太林 Catalog No. CSN11786

Synonyms: Pro-Banthine;Neometantyl;Neopepulsan

Propantheline bromide is an antimuscarinic agent, used for the treatment of hyperhidrosis, cramps or spasms of the stomach, intestines or bladder, and enuresis.

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生物活性

描述Propantheline bromide (PB) is a hydrolysable anti-cholinergic drug^[3]. In addition, propantheline bromide's effectiveness is more than would be expected by prevention of cardioinhibition in neurocardiogenic syncope and would support a role for direct cholinergic control of vascular tone^[4]. Vagal suppression was achieved in rats by administering 20 mg/kg propantheline i.p. 2 h and 1 h before gastric gavage of 20 mg/kg ibuprofen as small crushed pieces of a regular release and a fast-dissolving ibuprofen caplets^[5]. Propantheline bromide at doses of 0.03--0.3 mg/kg inhibited basal and pentagastrin stimulated gastric secretion, but had no effect on histamine stimulation^[6]. Subcutaneously administered propantheline bromide (30 mg/kg) or cimetidine (100 mg/kg) had no effect on gastric lesion and PD reduction caused by hemorrhagic shock^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01010048	Urinary Calculus	Phase 4	Unknown	December 2010	China, Chongqing ... more >> The First Affiliated Hospital, ChongQing medical University Recruiting ChongQing, Chongqing, China, 400016 Contact: Yunfeng He, Doctor 86-23-89011121 Contact: Xiaohou Wu, Doctor 86-23-89011122 Collapse <<
NCT01640002	Overactive Bladder Associated ... more >>With HTLV-1 Collapse <<	Phase 1	Unknown	April 2013	Brazil ... more >> Service of Imunology - Universitary Hospital Prof. Edgard Santos Recruiting Salvador, Bahia, Brazil, 40110-070 Contact: José Abraão Carneiro Neto 557132838392 abraao.neto@gmail.com Contact: Edgard Marcelino Carvalho Filho imuno@ufba.br Principal Investigator: Edgard Marcelino Carvalho Filho Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.2302 mL
- 11.1509 mL
- 22.3019 mL
- 5 mM
- 0.4460 mL
- 2.2302 mL
- 4.4604 mL
- 10 mM
- 0.2230 mL
- 1.1151 mL
- 2.2302 mL

技术信息

CAS号

50-34-0

储存条件

粉末: Inert atmosphere,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C23H30BrNO3

运输

蓝冰

分子量

448.39

别名

Pro-Banthine;Neometantyl;Neopepulsan;Propantheline (bromide);SC-3171;Propantheline Bromide;Pantheline;溴丙胺太林

溶解度

DMSO	260.0 mg/mL (579.8 mM)
Water	130.0 mg/mL (289.9 mM)

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