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CAS No.: 500-92-5
Synonyms: chlorguanide;chloroguanide;BRN-2811599
Proguanil is an inhibitor of dihydrofolate reductase (DHFR). It is antimalarial prodrug metabolized to the active metabolite cycloguanil.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00111163 | Malaria Anemi... more >>a Collapse << | Not Applicable | Completed | - | Kenya ... more >> Lwak, Abidha, Ongielo and Saradidi clinics Asembo (Rarieda Division), Nyanza Province, Kenya Collapse << |
NCT00164710 | Malaria, Falciparum | Phase 4 | Completed | - | Malawi ... more >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi Collapse << |
NCT00158561 | Malaria Vivax... more >> Malaria Collapse << | Phase 3 | Completed | - | Pakistan ... more >> HealthNet International Peshawar, Pakistan Collapse << |
实验方案
技术信息
CAS号 | 500-92-5 | 储存条件 |
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分子式 | C11H16ClN5 | 运输 | 蓝冰 | |
分子量 | 253.73 | 别名 | chlorguanide;chloroguanide;BRN-2811599;氯胍 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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NCT00111163 | Malaria Anemi... more >>a Collapse << | Not Applicable | Completed | - | Kenya ... more >> Lwak, Abidha, Ongielo and Saradidi clinics Asembo (Rarieda Division), Nyanza Province, Kenya Collapse << |
NCT00164710 | Malaria, Falciparum | Phase 4 | Completed | - | Malawi ... more >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi Collapse << |
NCT00158561 | Malaria Vivax... more >> Malaria Collapse << | Phase 3 | Completed | - | Pakistan ... more >> HealthNet International Peshawar, Pakistan Collapse << |
NCT00393679 | Fever Malaria | Phase 3 | Completed | - | Burkina Faso ... more >> Centre Muraz/IRSS Bobo-Dioulasso, Burkina Faso Gabon Albert Schweitzer Hospital Lambaréné, Gabon Mozambique Manhiça Health Research Center Manhica, Mozambique Nigeria Hospital Calabar, Nigeria Rwanda Mashshesha and Rukara Kigali, Rwanda Uganda Jinja and Tororo Kampala, Uganda Mbarara, Mbarara, Uganda Zambia Tropical Diseases Research Centre, P O Box 71769, Ndola, Zambia Collapse << |
NCT00158574 | Malaria | Phase 2 Phase 3 | Completed | - | Tanzania ... more >> Ministry of Health, Korogwe and Same District MCH clinics Tanga, Tanga and Kilimanjaro, Tanzania Collapse << |
NCT00344006 | Malaria, Falciparum | Phase 3 | Completed | - | Burkina Faso ... more >> GSK Investigational Site Bobo-Dioulasso, Burkina Faso Ghana GSK Investigational Site Kintampo, Ghana Kenya GSK Investigational Site Eldoret, Kenya GSK Investigational Site Kilifi, Kenya Nigeria GSK Investigational Site Barkin Ladi, Nigeria GSK Investigational Site Calabar, Nigeria GSK Investigational Site Enugu, Nigeria GSK Investigational Site Ibadan, Nigeria Tanzania GSK Investigational Site Ifakara, Tanzania Collapse << |
NCT00118794 | Malaria | Phase 3 | Completed | - | Gambia ... more >> Medical Research Council Laboratories Banjul, Gambia, POBOX273 Collapse << |
NCT00361114 | Malaria | Phase 3 | Terminated(SP arms were stoppe... more >>d due to high levels of treatment failure.CD not available.) Collapse << | - | Tanzania ... more >> Hale Dispensary Korogwe, Tanga Region, Tanzania Collapse << |
NCT00371735 | Malaria, Falciparum | Phase 3 | Completed | - | Burkina Faso ... more >> GSK Investigational Site Ouagadougou, Burkina Faso Ghana GSK Investigational Site Kumasi, Ghana Mali GSK Investigational Site Bamako, Mali Nigeria GSK Investigational Site Ile-Ife, Nigeria GSK Investigational Site Jos, Nigeria GSK Investigational Site Lagos, Nigeria GSK Investigational Site Maiduguri, Nigeria Collapse << |
NCT00164359 | Malaria, Falciparum | Phase 4 | Completed | - | Malawi ... more >> Kawale Health Center Lilongwe, Lilongwe District, Malawi Machinga District Hospital Liwonde, Machinga District, Malawi Matiki Health Center Dwangwa, Nkhotakota District, Malawi Collapse << |
NCT00519467 | Malaria | Phase 2 | Completed | - | Gambia ... more >> GSK Investigational Site Banjul, Gambia Malawi GSK Investigational Site Blantyre, Malawi, 30096,BLANTYRE 3 Collapse << |
NCT00461578 | Malaria | Not Applicable | Completed | - | Rwanda ... more >> Programme Nationale Integre de Lutte contre le Paludisme Kigali, Rwanda, BP 2514 Collapse << |
NCT03163121 | Malaria | Phase 1 | Recruiting | October 2018 | Netherlands ... more >> Leiden University Medical Center, Albinusdreef 2 Recruiting Leiden, Netherlands, 2333 ZA Contact: Leo G. Visser, MD 31715266354 l.g.visser@lumc.nl Contact: Meta Roestenberg, MD, PhD 31715264400 M.Roestenberg@lumc.nl Principal Investigator: Leo G. Visser, MD Radboud University Medical Center, Geert Grooteplein 28 Recruiting Nijmegen, Netherlands, 6525 GA Contact: Robert W. Sauerwein, MD 31243610577 Robert.Sauerwein@radboudumc.nl Contact: Jona Walk, MD 31243613663 Jona.Walk@radboudumc.nl Principal Investigator: Robert W. Sauerwein, MD Collapse << |
NCT02191358 | - | - | Completed | - | United States, California ... more >> Dr. Michael Dao Garden Grove, California, United States, 92844 United States, Colorado Kaiser Permanente Colorado Denver, Colorado, United States, 80011 United States, Kentucky Gill Heart Institute Lexington, Kentucky, United States, 40508 United States, Maryland IRC Clinics Towson, Maryland, United States, 21204 United States, Massachusetts Internal Medicine & Cardiology Associates Fall River, Massachusetts, United States, 02720 Prima CARE Fall River, Massachusetts, United States, 02720 United States, Virginia Carilion Clinic Christiansburg, Virginia, United States, 24073 Collapse << |
NCT00146731 | Malaria | Phase 3 | Completed | - | Tanzania ... more >> Muheza Designated District Hospital Muheza, Tanga, Tanzania, PB Collapse << |
NCT02054299 | Drug Metabolism ... more >> Membrane Transport Collapse << | Phase 1 | Completed | - | Germany ... more >> Department of Clinical Pharmacology, University Medical Center Goettingen Goettingen, Germany, 37075 Collapse << |
NCT00149383 | Falciparum Malaria | Phase 1 Phase 2 | Completed | - | Thailand ... more >> Faculty of Tropical Medicine, Mahidol University Bangkok, Thailand, 10400 Collapse << |
NCT00126971 | Malaria | Phase 1 | Suspended | - | Mali ... more >> Faladje Missionary Dispensary Faladje, Mali Collapse << |
NCT01269333 | Drug Interaction of Clopidogre... more >>l Collapse << | Phase 1 | Completed | - | Israel ... more >> Hadassah Medical Organization Jerusalem, Israel Collapse << |
NCT03454048 | Malaria,Falciparum ... more >> Gametocytes Controlled Human Malaria Infection Transmission Collapse << | Not Applicable | Recruiting | December 1, 2018 | Netherlands ... more >> Radboud university medical center Recruiting Nijmegen, Gelderland, Netherlands, 6525 GA Contact: Isaie Reuling 024 361 9515 ext +31 isaie.reuling@radboudumc.nl Collapse << |
NCT01479361 | HIV PCP ... more >> Toxoplasmosis Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
NCT02628080 | Carcinoma, Non-Small-Cell Lung | Early Phase 1 | Recruiting | February 2019 | United Kingdom ... more >> Churchill Hospital Recruiting Oxford, Oxfordshire, United Kingdom, OX3 7LE Contact: Eileen McKenzie trialadministrator02@oncology.ox.ac.uk Principal Investigator: Geoff Higgins, Dr Collapse << |
NCT02098590 | Malaria | Not Applicable | Completed | - | Netherlands ... more >> Radboud university medical center Nijmegen, Gelderland, Netherlands, 6525 GA Collapse << |
NCT02836002 | Malaria | Phase 1 Phase 2 | Completed | - | Netherlands ... more >> Radboud university medical center Nijmegen, Gelderland, Netherlands, 6525 GA Collapse << |
NCT01442168 | Malaria, Falciparum | Phase 1 Phase 2 | Terminated | - | Thailand ... more >> Mae Ramat Hospital Mae Ramat, Tak province, Thailand Maesot General hospital Mae Sot, Tak Province, Thailand Hospital for Tropical Diseases Bangkok, Thailand Collapse << |
NCT00298610 | Malaria | Phase 2 | Completed | - | Kenya ... more >> New Nyanza Provincial Hospital Kisumu, New Nyanza, Kenya Collapse << |
NCT01976325 | Malaria | Not Applicable | Unknown | November 2015 | Canada, Ontario ... more >> National Capital Region Occupational Health Clinic Recruiting Ottawa, Ontario, Canada, K1A 0K9 Contact: Louise J Levesque, RN, BScN 613-946-5533 louise.j.levesque@hc-sc.gc.ca Contact: Lisa Taras, MD, CCFP 613-946-6583 lisa.taras@hc-sc.gc.ca Ottawa Hospital Research Institute Recruiting Ottawa, Ontario, Canada, K1Y 4E9 Contact: Charde A Morgan, MScPH 613-737-8899 ext 72424 cmorgan@ohri.ca Contact: Anne E McCarthy, MD 613-737-8899 ext 78184 amccarthy@toh.on.ca Principal Investigator: Anne E McCarthy, MD, MSc Sub-Investigator: Charde A Morgan, MScPH International Association for Medical Assistance to Travellers Recruiting Toronto, Ontario, Canada, M6K 3E3 Contact: Tullia Marcolongo 416-652-0137 tullia@iamat.org Collapse << |
NCT00451139 | Malaria | Phase 4 | Completed | - | Ethiopia ... more >> Jimma University Hospital Jimma, Ethiopia Collapse << |
NCT00298610 | - | - | Completed | - | - |
NCT02564471 | Rabies | Phase 4 | Recruiting | December 2018 | United States, New York ... more >> State University of New York, Upstate Medical University (SUNY-UMU) Recruiting Syracuse, New York, United States, 13210 Contact: Lisa Ware, MS 315-464-4398 warel@upstate.edu Collapse << |
NCT01422954 | Malaria Plasm... more >>odium Falciparum Collapse << | Not Applicable | Completed | - | Netherlands ... more >> Leiden University Medical Centre Leiden, Netherlands, 2333 ZA Collapse << |
NCT03293641 | Sickle Cell Disease ... more >> Zinc Deficiency Infection Collapse << | Not Applicable | Completed | - | - |
NCT01218893 | Plasmodium Falciparum Malaria | Not Applicable | Completed | - | Netherlands ... more >> Leiden University Medical Centre Leiden, Netherlands, 2300 RC Collapse << |
NCT00386750 | Malaria Falci... more >>parum Collapse << | Phase 4 | Terminated | - | - |
NCT01055002 | Healthy Non-s... more >>mokers Collapse << | Phase 1 Phase 2 | Completed | - | Australia, Queensland ... more >> Q-Pharm Clinics, Royal Brisbane and Women's Hospital Brisbane, Queensland, Australia, 4006 Collapse << |
NCT02450578 | Falciparum Malaria | Phase 1 | Completed | - | Germany ... more >> Universitätsklinikum Tübingen, Institut für Tropenmedizin Tübingen, Germany, 72074 Collapse << |
NCT03178643 | Malaria,Falciparum | Phase 4 | Recruiting | October 2019 | Kenya ... more >> Homa Bay County Referral Hospital Recruiting Homa Bay Town, Homa Bay County, Kenya, 40300 Contact: Sarah Korwa, Nursing +254719474231 sarahkorwa@gmail.com Contact: Joseph Kipkoech +254719474231 josepheddykipkoech@gmail.com Principal Investigator: Festus Njuguna, MMedPed Collapse << |
NCT02080026 | Malaria | Not Applicable | Completed | - | Netherlands ... more >> Radboud university medical center Nijmegen, Gelderland, Netherlands, 6525 GA Collapse << |
NCT01704794 | Other Sickle-cell Disorders Wi... more >>th Crisis, Unspecified Collapse << | Phase 1 Phase 2 | Unknown | September 2014 | Nigeria ... more >> Lagos State University Teaching Hospital Recruiting Ikeja, Lagos, Nigeria, 100001 Contact: A O Dosunmu, M.D. 2348023369785 doyin_dosunmu@yahoo.com Principal Investigator: A O Dosunmu, M.D. Sub-Investigator: O O Odusanya, M.D. Sub-Investigator: I N AKinwunmi, M.D. Sub-Investigator: A A Akinbami, M.D. Sub-Investigator: M O Dada, M.D. Sub-Investigator: T M Balogun, M.D. Sub-Investigator: C K Yemitan, M.D. Sub-Investigator: J A Onakoya, M.D. Sub-Investigator: U O Oyekan, M.D. Collapse << |
NCT01703104 | Sickle Cell Anemia | Phase 1 Phase 2 | Completed | - | Nigeria ... more >> Lagos State University Teaching Hospital Ikeja, Lagos, Nigeria, 100001 Collapse << |
NCT01236612 | Plasmodium Falciparum Malaria | Not Applicable | Completed | - | Netherlands ... more >> Radboud University Nijmegen Medical Centre Nijmegen, Netherlands, 6500 HB Collapse << |
NCT01660854 | Malaria, Falciparum | Not Applicable | Completed | - | Netherlands ... more >> Leiden University Medical Centre Leiden, Netherlands, 2333ZA Collapse << |
NCT00421473 | HIV Infections ... more >> Malaria Collapse << | Phase 4 | Completed | - | Netherlands ... more >> Elisabeth hospital Tilburg, Brabant, Netherlands, 5022 GC Alysis Zorggroep loc. Rijnstate Arnhem, Gelderland, Netherlands, 6800 TA Radboud University Medical Centre Nijmegen Nijmegen, Gelderland, Netherlands, 6525 GA Leids Universitair Medisch Centrum Leiden, Zuid Holland, Netherlands, 2300 RC Erasmus MC Rotterdam, Zuid Holland, Netherlands, 3000 CA Collapse << |
NCT03278808 | Malaria | Phase 2 | Recruiting | September 1, 2020 | United States, Maryland ... more >> Clinical Research Unit, Uniformed Services University of Health Sciences Not yet recruiting Bethesda, Maryland, United States, 20814 Contact: Thomas Oliver, MD 301-295-0016 thomas.g.oliver.mil@mail.mil WRAIR Recruiting Silver Spring, Maryland, United States, 20910 Contact: Jeffrey R Livezey, MD 301-319-3217 jeffrey.r.livezey.mil@mail.mil Collapse << |
NCT00444106 | Malaria Falci... more >>parum Collapse << | Phase 4 | Completed | - | Colombia ... more >> Novartis Investigational Site Tumaco, Colombia Collapse << |
NCT02858817 | Malaria | Phase 1 | Unknown | March 2018 | - |
NCT01150344 | Malaria | Phase 4 | Completed | - | France ... more >> Hôpital Avicenne Bobigny, Seine St Denis, France, 93000 Collapse << |
NCT01319448 | Malaria Sickl... more >>e Cell Crisis Collapse << | Phase 1 Phase 2 | Completed | - | Nigeria ... more >> Department of Paediatrics and Child Health, University of Ilorin Teaching Hospital Ilorin, Kwara, Nigeria Collapse << |
NCT00444106 | - | - | Completed | - | - |
NCT00984256 | Malaria | Phase 2 | Completed | - | United States, Maryland ... more >> Walter Reed Army Institute of Research Silver Spring, Maryland, United States, 20910 Collapse << |
NCT00984256 | - | - | Completed | - | - |
NCT00084227 | Malaria, Falciparum | Phase 2 Phase 3 | Completed | - | - |
NCT01456546 | CYP2C19 Genotypes | Phase 1 | Completed | - | Denmark ... more >> Clinical Pharmacology, University of Southern Denmark Odense, Fyn, Denmark, DK-5000 Collapse << |
NCT00379821 | Plasmodium Falciparum Infectio... more >>n Collapse << | Phase 3 | Completed | - | Malawi ... more >> Blantyre Malaria Project - Ndirande Health Centre Blantyre, Malawi Collapse << |
NCT03726593 | Plasmodium Falciparum Malaria ... more >>(Drug Resistant) Collapse << | Phase 4 | Recruiting | June 30, 2021 | Cambodia ... more >> Kratie Referral Hospital Not yet recruiting Kratie, Cambodia Contact: Somaly Kieng, M.D +855 72 971 755 Contact: Chanthap Lon, M.D 855 23 881 845 chanthapl@afrims.org Sub-Investigator: Darapiseth Sea, MD Sub-Investigator: Dysoley Lek, MD Anlong Veng Referral Hospital Recruiting Ânlóng Vêng, Cambodia Contact: Phan Kong, M.A 016 51 09 09 Principal Investigator: Chanthap Lon, MD Sub-Investigator: Darapiseth Sea, MD Sub-Investigator: Dysoley Lek, MD Collapse << |
NCT01858831 | Malaria | Phase 1 | Completed | - | Japan ... more >> GSK Investigational Site Kagoshima, Japan, 890-0081 Collapse << |
NCT00379821 | - | - | Completed | - | - |
NCT02297477 | Malaria | Phase 4 | Active, not recruiting | February 2019 | Cambodia ... more >> Anlong Veng Referral Hospital Anlong Veng, Oddar Meancheay, Cambodia Collapse << |
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