|1-环己基-1-苯基-3-(吡咯烷-1-基)丙-1-醇盐酸盐|CsnPharm

CAS No.: 1508-76-5

Procyclidine HCl/丙环定盐酸盐 Catalog No. CSN11780

Synonyms: Tricyclamol hydrochloride;(±)-Procyclidine hydrochloride;Procyclidine (hydrochloride)

Procyclidine HCl is an potent anti-cholinergic agent, and is also known to have NMDA antagonist properties.

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400-920-2911

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技术信息

生物活性

描述Procyclidine HCl is a potent anti-cholinergic agent, and is also known to have NMDA antagonist properties^[2]. Procyclidine (up to 20 mg/kg i.p.) did not influence the electroconvulsive threshold per se, but when given in a dose of 10 mg/kg, it potentiated the protective activity of carbamazepine, diphenylhydantoin, phenobarbital and valproate, and in a dose of 20 mg/kg, that of diazepam against maximal electroshock-induced convulsions in mice. The chimney test in mice revealed, that application of procyclidine at 10 mg/kg together with phenobarbital and valproate, and procyclidine at 20 mg/kg with diazepam resulted in motor impairment^[3]. A triple regimen consisting of procyclidine, diazepam, and pentobarbital can effectively terminate soman-induced seizures that have lasted 30min or more^[4].
参考文献

[1] Jevtovic-Todorovic V, Meyenburg AP, et al. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48.
[2] Jevtovic-Todorovic V, Meyenburg AP, Olney JW, Wozniak DF. Anti-parkinsonian agents procyclidine and ethopropazine alleviate thermal hyperalgesia in neuropathic rats. Neuropharmacology. 2003 May;44(6):739-48
[3] Zarnowski T, Kleinrok Z, Turski WA, Czuczwar SJ. The NMDA antagonist procyclidine, but not ifenprodil, enhances the protective efficacy of common antiepileptics against maximal electroshock-induced seizures in mice. J Neural Transm Gen Sect. 1994;97(1):1-12
[4] Myhrer T, Skymoen LR, Aas P. Pharmacological agents, hippocampal EEG, and anticonvulsant effects on soman-induced seizures in rats. Neurotoxicology. 2003 Jun;24(3):357-67

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0874 mL
- 15.4368 mL
- 30.8737 mL
- 5 mM
- 0.6175 mL
- 3.0874 mL
- 6.1747 mL
- 10 mM
- 0.3087 mL
- 1.5437 mL
- 3.0874 mL

技术信息

CAS号

1508-76-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C19H30ClNO

运输

蓝冰

分子量

323.90

别名

Tricyclamol hydrochloride;(±)-Procyclidine hydrochloride;Procyclidine (hydrochloride);Procyclidine HCl;(-)-Tricyclamol iodide;C19H29NO.HCl;Rosemont Brand of Procyclidine Hydrochloride;Tricyclamol;Wellcome Brand of Procyclidine Hydrochloride;丙环定盐酸盐

溶解度

DMSO	10.66 mg/mL (32.9 mM)

动物实验配方

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