生物活性

• 描述Prasugrel maleic acid is a platelet inhibitor with IC50 value of 1.8 μM.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT01438840	Chronic Thrombocytopenia ... more >> Immune Thrombocytopenia Collapse <<	Phase 3	Completed	-	Australia ... more >> Adelaide, Australia Bedford Park, Australia Belgium Antwerpen, Belgium Bulgaria Plovdiv, Bulgaria Sofia, Bulgaria Czechia Brno, Czechia Hradec Kralove, Czechia Praha, Czechia Netherlands Rotterdam, Netherlands New Zealand Christchurch, New Zealand Palmerston North, New Zealand Poland Bialystok, Poland Chorzow, Poland Gdansk, Poland Krakow, Poland Lodz, Poland Wroclaw, Poland Singapore Singapore, Singapore Slovakia Bratislava, Slovakia South Africa Johannesburg, South Africa Ukraine Dnipropetrovsk, Ukraine Donetsk, Ukraine Ivano-Frankivsk, Ukraine Kyiv, Ukraine Lviv, Ukraine Collapse <<
  NCT01433978	-	-	Terminated(Study was terminate... more >>d early due to significant enrollment challenges.) Collapse <<	-	-
  NCT01438840	-	-	Completed	-	-

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• 参考文献

• [1] Baker WL, White CM. Role of prasugrel, a novel P2Y(12) receptor antagonist, in the management of acute coronary syndromes. Am J Cardiovasc Drugs. 2009;9(4):213-29.

  [2] Sugidachi A, Ogawa T, Kurihara A, et al. The greater in vivo antiplatelet effects of prasugrel as compared to clopidogrel reflect more efficient generation of its active metabolite with similar antiplatelet activity to that of clopidogrel's active metabolite. J Thromb Haemost. 2007 Jul;5(7):1545-51.