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CAS No.: 1093070-14-4

PLpro inhibitor/PLpro抑制剂 Catalog No. CSN17457

Synonyms: PLpro Inhibitor 6;KOM-70144

PLpro inhibitor is a potent inhibitor of papain-like protease (PLpro) with IC50 of 2.6 μM.

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技术信息

生物活性

描述The papain-like protease (PLpro) can process the viral polyprotein in a coordinated manner and strip ubiquitin and ISG15 from host-cell proteins to aid coronaviruses in their evasion of the host innate immune responses. Therefore, PLpro is an attractive antiviral drug target for its essential role for coronaviral replication^[2]. PLpro inhibitor is a potent inhibitor against the PLpro from the coronavirus that causes severe acute respiratory syndrome (SARS-CoV). PLpro inhibitor was found to have an IC₅₀ value of 2.6 ± 0.1 μM. PLpro inhibitor displayed significant antiviral activity with an EC₅₀ value of 13.1 ± 0.7 uM, without toxicity up to the highest concentration tested. Notably, the increasing antiviral potency correlated with the in vitro inhibition of PLpro, suggesting that the compound works directly on the enzyme in cellshttp://www.google.com/patents/WO2010022355A1cl=en.
参考文献

[1] Ratia, K., et al., A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication. Proc Natl Acad Sci U S A, 2008. 105(42): p. 16119-24.
[2] Báez-Santos YM, et al. The SARS-coronavirus papain-like protease: structure, function and inhibition by designed antiviral compounds. Antiviral Res. 2015 Mar;115:21-38

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8867 mL
- 14.4333 mL
- 28.8665 mL
- 5 mM
- 0.5773 mL
- 2.8867 mL
- 5.7733 mL
- 10 mM
- 0.2887 mL
- 1.4433 mL
- 2.8867 mL

技术信息

CAS号

1093070-14-4

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C22H22N2O2

运输

蓝冰

分子量

346.42

别名

PLpro Inhibitor 6;KOM-70144

溶解度

DMSO	66.0 mg/mL (190.5 mM)
Water	Insoluble
Ethanol	35.0 mg/mL (101.0 mM)

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