|(2S,3R,4S,5S)-3-(((2S,3R,4S,5R,6S)-5-(((2S,3R,4S,5R)-4-(((2S,3R,4R)-3,4-二羟基-4-(羟甲基)四氢呋喃-2-基)氧基)-3,5-二羟基四氢-2H-吡喃-2-基)氧基)-3,4-二羟基-6-甲基四氢-2H -吡喃-2-基)氧基)-4,5-二羟基四氢呋喃-2H-吡喃-2-基 (4aR,5R,6aS,6bR,8aR,10R,11S,12aR,12bR,14bS)-5,11-二羟基-9,9-双(羟甲基)-2,2,6a,6b,12a-五甲基-10-(((2R,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基))四氢-2H-吡喃-2-基)氧基)-1,3,4,5,6,6a,6b,7,8,8a,9,10,11,12,12a,12b,13,14b-十八氢蒎烯-4a(2H)-羧酸酯|CsnPharm

CAS No.: 58479-68-8

Platycodin D/桔梗皂苷D Catalog No. CSN11740

Synonyms: 桔梗皂苷 D

Platycodin D is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90/cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70.

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技术信息

生物活性

描述Platycodin D (PLD) is a natural product isolated and purified from the root of Platycodon grandiflorum., which may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA, and is an Hsp90 inhibitor which disrupting the co-chaperone interaction of Hsp90/cell division cycle protein 37 (Cdc37) and subsequently degrading multiple Hsp90 client proteins without the feedback increase of Hsp70^[3]. Platycodin D repressed the osteoclast activity and enhanced bone mineral density in the mouse model. In C3H10T1/2 cells, platycodin D upregulated osteogenic markers including alkaline phosphatase (ALP), bone sialoprotein, and collagen type 1 alpha 1, and transcription factors, such as Runx2 and osterix, subsequently enhancing the bone mineralization. Furthermore, platycodin D upregulated the ALP activity and enhanced the mineralization process in osteoblast cells via the sirtuin 1/β-catenin pathways^[4]. Platycodin D reduces the protein level of PD-L1 in lung cancer cells via triggering its release into the cell culture medium^[5]. PLD protected BV-2 cells from MPP+(1-methyl-4-phenylpyridinium) -induced inflammatory response via regulating the TLR4-MyD88-NF-κB signaling pathway^[6]. PLD executes its protective effects on OGD/R(oxygen-glucose deprivation/reperfusion)-induced cell injury via regulating the PI3K/Akt/mTOR pathway in cortical neurons^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 0.8161 mL
- 4.0806 mL
- 8.1611 mL
- 5 mM
- 0.1632 mL
- 0.8161 mL
- 1.6322 mL
- 10 mM
- 0.0816 mL
- 0.4081 mL
- 0.8161 mL

技术信息

CAS号

58479-68-8

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C57H92O28

运输

蓝冰

分子量

1225.32

别名

桔梗皂苷 D

溶解度

DMSO	100.0 mg/mL (81.6 mM)

动物实验配方

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