|(E)-(2R,3R,4R,5R,6R)-6-(3,4-二羟基苯乙氧基)-5-羟基-2-(羟甲基)-4-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-(羟甲基)四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-3-基 3-(3,4-二羟基苯基)丙烯酸酯|CsnPharm

CAS No.: 104777-68-6

plantamajoside/大车前苷 Catalog No. CSN19900

Synonyms: OP45063;车前子甙;大车前苷

Plantamajoside, a natural product isolated and purified from the herb of Plantago depressa Willd., has anti-hepatotoxic, anti-inflammatory, antinociceptive activities, improving sexual function and antioxidant activity.

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400-920-2911

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生物活性

描述Plantamajoside (PMS) is a phenylpropanoid glycoside isolated from Plantago asiatica L.(Plantaginaceae). Plantamajoside ameliorated the lung injury that was induced by LPS. Plantamajoside suppressed the production of IL-1β, IL-6 and TNF-α in a dose-dependent manner. Plantamajoside inhibited the phosphorylation of IκBα, p65, p38, JNK and ERK. Plantamajoside has protective effect on LPS-induced ALI (acute lung injury) in mice and in RAW264.7 cells^[3]. In vitro, PMS inhibited the ISO(isoproterenol)-induced increase in H9c2 cell surface area and the mRNA expression of ANP, BNP and Myh7. In vivo, PMS improved the ISO-induced decrease in cardiac function, inhibited the increase in cardiac anatomical parameters and alleviated the histopathological changes in cardiac tissues^[4]. PMS inhibited the invasion, migration and viability of malignant melanoma cells. In addition, PMS induced apoptosis by regulating the expression levels of apoptotic-related genes and the activation of the PI3K/AKT signaling pathway, thereby exerting anti-malignant melanoma effects^[5]. Plantamajoside decreased the production of PGE2, NO, IL-6, and IL-8 in LPS-stimulated HGFs. LPS-induced NF-κB p65 and IκB phosphorylation were also suppressed by plantamajoside. Furthermore, plantamajoside inhibited LPS-induced PI3K and AKT phosphorylation^[6]. PMS protected against myocardial I/R injury via attenuating oxidative stress, inflammatory response and apoptosis^[7].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.5611 mL
- 7.8053 mL
- 15.6107 mL
- 5 mM
- 0.3122 mL
- 1.5611 mL
- 3.1221 mL
- 10 mM
- 0.1561 mL
- 0.7805 mL
- 1.5611 mL

技术信息

CAS号	104777-68-6	储存条件	粉末 Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C29H36O16	运输	蓝冰
分子量	640.59	别名	OP45063;车前子甙;大车前苷

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