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CAS No.: 344458-15-7
Synonyms: PJ-34 (hydrochloride);PJ-34;PJ-34 HCl
PJ34 HCl is a potent specific inhibitor of PARP-l/2 with IC50 of 110 nM and 86 nM.
生物活性
靶点 | PARP1 EC50:20nM | PARP2 EC50:20nM |
实验方案
技术信息
CAS号 | 344458-15-7 | 储存条件 |
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分子式 | C17H18ClN3O2 | 运输 | 蓝冰 | |||||||||||
分子量 | 331.80 | 别名 | PJ-34 (hydrochloride);PJ-34;PJ-34 HCl | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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Escherichia coli BL21 Star (DE3) cells | - | Function assay | - | Inhibition of 6xhis-tagged ARTD5 (unknown origin) expressed in Escherichia coli BL21 Star (DE3) cells, IC50=0.57 μM | 24900770 |
Escherichia coli Rosetta2 (DE3) cells | - | Function assay | - | Inhibition of human N-terminal 6xhis-tagged ARTD6 (873 to 1161) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay, IC50=0.21878 μM | 24900770 |
HeLa cells | - | Function assay | - | Inhibition of PARP1 in human HeLa cells by fluid scintillation counting using [adenylated-32P]NAD as substrate, IC50=0.02 μM | 18713665 |
MEF cells | - | Proliferation assay | 72 h | Antiproliferative activity against MEF cells harboring Brca1 deletion mutant at exon 11 assessed as cell viability after 72 hrs by MTT assay, IC50=13.2 μM | 22365563 |
MEF cells | - | Proliferation assay | 72 h | Antiproliferative activity against wild type MEF cells assessed as cell viability after 72 hrs by MTT assay, IC50=19.8 μM | 22365563 |
靶点 | Description | IC50 |
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PARP1 | EC50:20nM | |
PARP2 | EC50:20nM |
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