|4-哌啶甲酸|CsnPharm

CAS No.: 498-94-2

4-哌啶甲酸 Catalog No. CSN25408

Synonyms: 4-Piperidinecarboxylic acid;4-Carboxypiperidine;Hexahydroisonicotinic acid

Isonipecotic acid is a specific GABAA receptor agonist.

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400-920-2911

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Isonipecotic acid was less potent than its unsaturated analogue isoguvacine as a GABA-mimetic and as an inhibitor of GABA binding^[2]. The depolarizing action of all 4 analogues muscimol, isonipecotic acid, isoguvacine and N-methyl isoguvacine could be selectively antagonized by bicuculline methochloride and isopropyl bicyclophosphate. The potency of isoguvacine was 0.23 +/- 0.026 and isonipecotic acid 0.011 +/- 0.0028^[3]. Modifications of the isonipecotic acid fragment of SNS-032 results in analogs which are more permeable and lower effluxed than SNS-032^[4]. The most significant activity was demonstrated by the p-nitrophenyl esters of nipecotic and isonipecotic acids against bicuculline-induced seizures^[5]. In vivo tests revealed statistically significant antinociceptive properties of isonipecotic acid (10 and 30 mg/kg), R-nipecotic acid (30 and 100 mg/kg) and S-nipecotic acid (100 mg/kg) in mice^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.7425 mL
- 38.7126 mL
- 77.4251 mL
- 5 mM
- 1.5485 mL
- 7.7425 mL
- 15.4850 mL
- 10 mM
- 0.7743 mL
- 3.8713 mL
- 7.7425 mL

技术信息

CAS号

498-94-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C6H11NO2

运输

蓝冰

分子量

129.16

别名

4-Piperidinecarboxylic acid;4-Carboxypiperidine;Hexahydroisonicotinic acid;4-哌啶甲酸;异烟酸

溶解度

DMSO

Insoluble

动物实验配方

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