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CAS No.: 154235-83-3

安帕来斯 Catalog No. CSN10196

Synonyms: BDP 12;Ampakine CX 516;Ampalex

Ampalex is a positive allosteric modulator of AMPAR and is researched as a treatment for Alzheimer's disease.

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描述Ampalex (Ampakine, CX516) is an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI) ^[3]. This AMPAkine can be administered directly into the prefrontal cortex to provide analgesia, and that prefrontal AMPAkine infusion, similar to systemic administration, can provide added pain relief to complement morphine analgesia^[4]. BDNF(brain-derived neurotrophic factor) expression is influenced by lower doses of, and shorter treatments with, the ampakine than is AMPAR expression^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00858689	Fragile X Syndrome	Not Applicable	Completed	-	Canada, Ontario ... more >> Surrey Place Centre Toronto, Ontario, Canada, M5S 2C2 Collapse <<
NCT00858689	-	-	Completed	-	-
NCT00235352	Schizophrenia	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Collapse <<

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.1444 mL
- 20.7221 mL
- 41.4442 mL
- 5 mM
- 0.8289 mL
- 4.1444 mL
- 8.2888 mL
- 10 mM
- 0.4144 mL
- 2.0722 mL
- 4.1444 mL

技术信息

CAS号

154235-83-3

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H15N3O

运输

蓝冰

分子量

241.29

别名

BDP 12;Ampakine CX 516;Ampalex;Benzoyl-Piperidine-12;SPD-420;brand name: Ampalex;安帕来斯

溶解度

DMSO	46.0 mg/mL (190.6 mM)
Ethanol	48.0 mg/mL (198.9 mM)

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00858689	Fragile X Syndrome	Not Applicable	Completed	-	Canada, Ontario ... more >> Surrey Place Centre Toronto, Ontario, Canada, M5S 2C2 Collapse <<
NCT00858689	-	-	Completed	-	-
NCT00235352	Schizophrenia	Phase 2 Phase 3	Completed	-	United States, Massachusetts ... more >> Freedom Trail Clinic Boston, Massachusetts, United States, 02114 Collapse <<
NCT00001662	Alzheimer's Disease ... more >> Dementia Collapse <<	Phase 2	Completed	-	United States, Maryland ... more >> National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland, United States, 20892 Collapse <<
NCT00040443	Mild Cognitive Impairment	Phase 2	Completed	-	United States, Arizona ... more >> Pivotal Research Centers Peoria, Arizona, United States, 85381 United States, California University of California Irvine Irvine, California, United States, 92697 University of California at Los Angeles Los Angeles, California, United States, 90095 University of California, San Diego San Diego, California, United States, 92093 United States, Connecticut Yale University School of Medicine New Haven, Connecticut, United States, 06510 United States, Florida Sun Coast Gerontology Center, University of South Florida Tampa, Florida, United States, 33617 United States, Iowa Mercy Mayo Clinic Des Moines, Iowa, United States, 50314 United States, Pennsylvania University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15213 Collapse <<
NCT00040443	-	-	Completed	-	-
NCT00054730	Fragile X Syndrome ... more >> Autism Collapse <<	Phase 2	Completed	-	United States, California ... more >> UC Davis-MIND Institute Sacramento, California, United States, 95817 United States, Illinois RUSH-Presbyterian-St. Luke's Medical Center Chicago, Illinois, United States, 60612 Collapse <<

安帕来斯 Catalog No. CSN10196

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