|哌啶-2-羧酸|CsnPharm

CAS No.: 535-75-1

DL-2-哌啶甲酸 Catalog No. CSN25150

Synonyms: 六氢吡啶-alpha-羧酸;哌啶-2-甲酸;呢可酸

Pipecolic acid, a metabolite of lysine found in human physiological fluids such as urine, plasma and CSF, is an important regulator of immunity in plants and humans alike.

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400-920-2911

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生物活性

描述Pipecolic acid, a metabolite of Lysine, is an important precursor of many useful microbial secondary metabolites^[1]. Pipecolic acid, a non-proteinogenic amino acid, is a metabolite in lysine metabolism and a key chiral precursor in local anesthesia and macrolide antibiotics^[2]. Pipecolic acid (Pip) is an essential component of systemic acquired resistance, priming resistance in Arabidopsis thaliana against (hemi)biotrophic pathogens. Exogenous application of Pip induced resistance in barley against the hemibiotrophic bacterial pathogen Xanthomonas translucens pv. cerealis. Pip induces barley innate immune responses by triggering NO and priming reactive oxygen species accumulation^[3]. Moreover, in plants, Pip confers SAR by increasing levels of the free radicals, nitric oxide (NO), and reactive oxygen species (ROS), which act upstream of glycerol-3-phosphate (G3P)^[4].
参考文献

[1] He M. Pipecolic acid in microbes: biosynthetic routes and enzymes. J Ind Microbiol Biotechnol. 2006 Jun;33(6):401-7
[2] Han YH, Choi TR, Park YL, Park JY, Song HS, Kim HJ, Lee SM, Park SL, Lee HS, Bhatia SK, Gurav R, Yang YH. Enhancement of pipecolic acid production by the expression of multiple lysine cyclodeaminase in the Escherichia coli whole-cell system. Enzyme Microb Technol. 2020 Oct;140:109643
[3] Lenk M, Wenig M, Bauer K, Hug F, Knappe C, Lange B, Timsy, Häußler F, Mengel F, Dey S, Schäffner A, Vlot AC. Pipecolic Acid Is Induced in Barley upon Infection and Triggers Immune Responses Associated with Elevated Nitric Oxide Accumulation. Mol Plant Microbe Interact. 2019 Oct;32(10):1303-1313
[4] Wang C, Liu R, Lim GH, de Lorenzo L, Yu K, Zhang K, Hunt AG, Kachroo A, Kachroo P. Pipecolic acid confers systemic immunity by regulating free radicals. Sci Adv. 2018 May 30;4(5):eaar4509

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.7425 mL
- 38.7126 mL
- 77.4251 mL
- 5 mM
- 1.5485 mL
- 7.7425 mL
- 15.4850 mL
- 10 mM
- 0.7743 mL
- 3.8713 mL
- 7.7425 mL

技术信息

CAS号	535-75-1	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C6H11NO2	运输	蓝冰
分子量	129.16	别名	六氢吡啶-alpha-羧酸;哌啶-2-甲酸;呢可酸;2-哌啶甲酸;六氢吡啶羧酸

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