|N-(1-甲基-2-苯氧乙基)-N-(2-氯乙基)苯甲胺盐酸盐|CsnPharm

CAS No.: 63-92-3

Phenoxybenzamine HCl/盐酸酚苄明 Catalog No. CSN12736

Synonyms: NSC 37448;NCI-c01661;Dibenzyline HCl

Phenoxybenzamine HCl is a non-selective irreversible dibenzamine α adrenergic antagonist with antihypertensive and vasodilatory properties.

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400-920-2911

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实验方案

技术信息

生物活性

描述Phenoxybenzamine hydrochloride is a selective antagonist of both α-adrenoceptor and calmodulin that is commonly used for the treatment of hypertension, specifically caused by pheochromocytoma. The IC50 (100 nM) derived from the blockade of [3H]yohimbine binding by phenoxybenzamine was significantly less than the IC50 (550 nM) for the corresponding reversal by phenoxybenzamine of the effects of norepinephrine on cyclic AMP accumulation^[2]. Phenoxybenzamine hydrochloride (50 nM) in conbination with Phenoxybenzamine hydrochloridetolamine (1000 nM) enhances Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with pretreatment with Phenoxybenzamine hydrochloride (50 nM) alone in endothelium-intact aortae. Combined treatment with either dexmedetomidine (300 or 1000 nM) and Phenoxybenzamine hydrochloride (50 nM) or Phenoxybenzamine hydrochloridetolamine (1000 nM) and Phenoxybenzamine hydrochloride (50 nM) enhance Phenoxybenzamine hydrochlorideylephrine-induced contraction compared with Phenoxybenzamine hydrochloride alone (50 nM)^[3]. PHEN (Phenoxybenzamine Hydrochloride) exhibited a significant inhibitory effect on the proliferation of both U251 and U87MG glioma cell lines in a positive dose-dependent manner. PHEN apparently attenuated the malignancy of glioma in terms of migration and invasion and also suppressed the tumorigenic capacity both in vitro and in vivo^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03176693	Pheochromocytoma ... more >> Paraganglioma Collapse <<	Phase 3	Recruiting	May 2024	United States, California ... more >> University of California, Los angeles Recruiting Los Angeles, California, United States, 90025 Principal Investigator: Masha J Livhits, MD Sub-Investigator: Eric J Kuo, MD Collapse <<
NCT00569855	-	-	Completed	-	-
NCT00569855	Open-heart Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Phase 2	Completed	-	United States, Arkansas ... more >> Arkansas Children's Hospital Little Rock, Arkansas, United States, 72207 Collapse <<

更多
参考文献

[1] Byon HJ, Ok SH, et al. Dexmedetomidine Inhibits Phenylephrine-induced Contractions via Alpha-1 Adrenoceptor Blockade and Nitric Oxide Release in Isolated Rat Aortae. Int J Med Sci. 2017 Feb 7;14(2):143-149.
[2] Lenox RH, Ellis J, Van Riper D, Ehrlich YH. Alpha 2-adrenergic receptor-mediated regulation of adenylate cyclase in the intact human platelet. Evidence for a receptor reserve. Mol Pharmacol. 1985;27(1):1-9
[3] Byon HJ, Ok SH, Lee SH, et al. Dexmedetomidine Inhibits Phenylephrine-induced Contractions via Alpha-1 Adrenoceptor Blockade and Nitric Oxide Release in Isolated Rat Aortae. Int J Med Sci. 2017;14(2):143-149. Published 2017 Feb 7
[4] Lin XB, Jiang L, Ding MH, et al. Anti-tumor activity of phenoxybenzamine hydrochloride on malignant glioma cells. Tumour Biol. 2016;37(3):2901-2908

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9387 mL
- 14.6935 mL
- 29.3869 mL
- 5 mM
- 0.5877 mL
- 2.9387 mL
- 5.8774 mL
- 10 mM
- 0.2939 mL
- 1.4693 mL
- 2.9387 mL

技术信息

CAS号

63-92-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C18H23Cl2NO

运输

蓝冰

分子量

340.29

别名

NSC 37448;NCI-c01661;Dibenzyline HCl;Phenoxybenzamine (hydrochloride);Phenoxybenzamine;Phenoxybenzamine HCl;Dibenzyline;盐酸酚苄明

溶解度

DMSO	100.0 mg/mL (293.9 mM)
Water	insoluble

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03176693	Pheochromocytoma ... more >> Paraganglioma Collapse <<	Phase 3	Recruiting	May 2024	United States, California ... more >> University of California, Los angeles Recruiting Los Angeles, California, United States, 90025 Principal Investigator: Masha J Livhits, MD Sub-Investigator: Eric J Kuo, MD Collapse <<
NCT00569855	-	-	Completed	-	-
NCT00569855	Open-heart Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Phase 2	Completed	-	United States, Arkansas ... more >> Arkansas Children's Hospital Little Rock, Arkansas, United States, 72207 Collapse <<
NCT00620945	Congenital Heart Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Not Applicable	Terminated(New protocol now be... more >>ing used for cardiopulmonary bypass) Collapse <<	-	-
NCT00620945	-	-	Terminated(New protocol now be... more >>ing used for cardiopulmonary bypass) Collapse <<	-	-
NCT00770705	Congenital Heart Disease	Phase 2	Withdrawn(poor enrollment)	-	United States, Tennessee ... more >> Vanderbilt Children's Hospital Nashville, Tennessee, United States, 37232 Collapse <<
NCT01379898	Pheochromocytoma	Phase 4	Completed	-	Netherlands ... more >> Department of Endocrinology, University Medical Center Groningen Groningen, Netherlands, 9700 RB Collapse <<
NCT03176693	Pheochromocytoma ... more >> Paraganglioma Collapse <<	Phase 3	Recruiting	May 2024	United States, California ... more >> University of California, Los angeles Recruiting Los Angeles, California, United States, 90025 Principal Investigator: Masha J Livhits, MD Sub-Investigator: Eric J Kuo, MD Collapse <<
NCT00770705	Congenital Heart Disease	Phase 2	Withdrawn(poor enrollment)	-	United States, Tennessee ... more >> Vanderbilt Children's Hospital Nashville, Tennessee, United States, 37232 Collapse <<
NCT00569855	Open-heart Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Phase 2	Completed	-	United States, Arkansas ... more >> Arkansas Children's Hospital Little Rock, Arkansas, United States, 72207 Collapse <<
NCT00569855	-	-	Completed	-	-
NCT00620945	Congenital Heart Surgery ... more >> Cardiopulmonary Bypass Collapse <<	Not Applicable	Terminated(New protocol now be... more >>ing used for cardiopulmonary bypass) Collapse <<	-	-
NCT01379898	Pheochromocytoma	Phase 4	Completed	-	Netherlands ... more >> Department of Endocrinology, University Medical Center Groningen Groningen, Netherlands, 9700 RB Collapse <<
NCT00620945	-	-	Terminated(New protocol now be... more >>ing used for cardiopulmonary bypass) Collapse <<	-	-

Phenoxybenzamine HCl/盐酸酚苄明 Catalog No. CSN12736

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