CAS No.: 1004990-28-6
PF-AKT400 Catalog No. CSN17274
Synonyms: AKT protein kinase inhibitor;Lig-1;AKT-0286
AKT inhibitor is a broadly selective, potent, ATP-competitive Akt inhibitor, displays 900-fold greater selectivity for PKBα (IC50 = 0.5 nM) than PKA (IC50=450 nM).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT03543683 Non-Small Cell Lung Cancer Sta... more >>ge IIIB Non-small Cell Lung Cancer Stage IV EGFR T790M Collapse << Phase 2 Not yet recruiting June 30, 2021 - NCT02301988 Breast Cancer Phase 2 Completed - - NCT00831454 - - Completed - Italy ... more >> Istituto Clinco Humanitas Rozzano, Mialno, Italy, 20089 Collapse << - 更多
- 参考文献
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1004990-28-6 | 储存条件 |
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| 分子式 | C20H22F2N6O | 运输 | 蓝冰 | |
| 分子量 | 400.43 | 别名 | AKT protein kinase inhibitor;Lig-1;AKT-0286;ZINC-111606147 |
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
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| NCT03543683 | Non-Small Cell Lung Cancer Sta... more >>ge IIIB Non-small Cell Lung Cancer Stage IV EGFR T790M Collapse << | Phase 2 | Not yet recruiting | June 30, 2021 | - |
| NCT02301988 | Breast Cancer | Phase 2 | Completed | - | - |
| NCT00831454 | - | - | Completed | - | Italy ... more >> Istituto Clinco Humanitas Rozzano, Mialno, Italy, 20089 Collapse << |
| NCT02301988 | - | - | Completed | - | - |
| NCT00832598 | Brain Cancer ... more >>Gliomas Collapse << | Not Applicable | Completed | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT00832598 | - | - | Completed | - | - |
| NCT01412515 | Kaposi Sarcoma | Phase 2 | Terminated(results from interi... more >>m analysis conducted to study interruption) Collapse << | - | France ... more >> Hospital Saint Louis Paris, France, 75010 Collapse << |
| NCT01896531 | Gastric Cancer | Phase 2 | Active, not recruiting | June 30, 2019 | - |
| NCT01811667 | Cardiovascular Abnormalities | Phase 3 | Completed | - | Belgium ... more >> Cliniques universitaires Saint-Luc Brussels, Belgium, 1200 Collapse << |
| NCT01033721 | Age-Related Macular Degenerati... more >>on Collapse << | Phase 1 | Completed | - | United States, Massachusetts ... more >> Ophthalmic Consultants of Boston Boston, Massachusetts, United States, 02114 Collapse << |
| NCT01992952 | Estrogen Receptor Positive Bre... more >>ast Cancer Collapse << | Phase 1 Phase 2 | Active, not recruiting | October 2020 | United Kingdom ... more >> Christie Hospital Manchester, Greater Manchester, United Kingdom Ysbyty Gwynedd Bangor, United Kingdom Clatterbridge Cancer Centre Bebington, United Kingdom Royal Blackburn Hospital Blackburn, United Kingdom Blackpool Victoria Hospital Blackpool, United Kingdom Velindre NHS Trust Cardiff, United Kingdom University Hospital of North Durham Durham, United Kingdom Great Western General Hospital Edinburgh, United Kingdom Calderdale and Huddersfield NHS Foundation Trust Huddersfield, United Kingdom The Ipswich Hospital NHS Trust Ipswich, United Kingdom University Hospitals Morecambe Bay Lancaster, United Kingdom St James's University Hospital Leeds, United Kingdom Mount Vernon Cancer Centre London, United Kingdom Royal Free Hospital London, United Kingdom Derriford Hospital Plymouth, United Kingdom Royal Preston Hospital Preston, United Kingdom Glan Clwyd Hospital Rhyl, United Kingdom Queen's Hospital Romford, United Kingdom Southampton General Hospital Southampton, United Kingdom Royal Stoke University Hospital Stoke-on-Trent, United Kingdom Royal Albert and Edward Infirmary -Wrightington Wigan, United Kingdom Collapse << |
| NCT01915576 | Neoplasms | Phase 1 | Completed | - | United States, California ... more >> Santa Monica, California, United States, 90404 United States, Massachusetts Boston, Massachusetts, United States, 02215 United States, Missouri St. Louis, Missouri, United States, 63110 United States, Texas Houston, Texas, United States, 77030 France Villejuif Cedex, France, 94805 Germany Heidelberg, Baden-Württemberg, Germany, 69120 Switzerland St. Gallen, Sankt Gallen, Switzerland, 9007 Collapse << |
| NCT02306135 | - | - | Terminated | - | United States, New Hampshire ... more >> Dartmouth-Hitchcock Medical Center Lebanon, New Hampshire, United States, 03756 Collapse << |
| NCT02523014 | Intracranial Meningioma ... more >> Recurrent Meningioma NF2 Gene Mutation Collapse << | Phase 2 | Suspended(No arms are currentl... more >>y open to patient registration) Collapse << | - | - |
| NCT03318263 | Breast Cancer | Not Applicable | Recruiting | June 2021 | France ... more >> Hôpital Claude Bernard Recruiting Metz, France, 57070 Contact: GARDNER Miriam, MD CHR Metz-Thionville Recruiting Metz, France, 57085 Contact: LONGO Rafaelle, MD Centre d'oncologie Gentilly Recruiting Nancy, France Contact: Célia BECUWE, MD Institut Jean Godinot Recruiting Reims, France, 51100 Contact: SAVOYE Aude-Marie, MD Polyclinique de Courlancy Recruiting Reims, France, 51100 Contact: PRULHIERE Karine, MD Centre Henri Becquerel Recruiting Rouen, France, 76038 Contact: Florian CLATOT, MD Polyclinique de l'Orangerie Not yet recruiting Strasbourg, France, 67000 Contact: ACHILLE Mihaela, MD Clinique Saint Anne Recruiting Strasbourg, France, 67085 Contact: TAZI Youssef, MD CHU Strasbourg Recruiting Strasbourg, France, 67091 Contact: BARHELEMY Philippe, MD Institut de cancérologie de Lorraine Recruiting Vandœuvre-lès-Nancy, France, 54509 Contact: MASSARD VINCENT, MD v.massard@nancy.unicancer.fr Collapse << |
| NCT02489266 | Metastatic Melanoma | Phase 1 | Withdrawn | - | - |
| NCT02441543 | - | - | Recruiting | May 2018 | Italy ... more >> Istituto Clinico Humanitas Recruiting Rozzano, MI, Italy, 20089 Contact: Enrico Lugli 02 8224 ext 5143 Enrico.Lugli@humanitasresearch.it Contact: Matteo Simonelli 02 8224 ext 4559 matteo.simonelli@humanitas.it Principal Investigator: Lugli Enrico Sub-Investigator: Simonelli Matteo Collapse << |
| NCT03176485 | Metastatic Cancer ... more >> Melanoma Colon Cancer Differentiated Thyroid Cancer Hepatocellular Carcinoma Renal Cell Carcinoma Metastatic Melanoma HCC Metastatic Colon Cancer Collapse << | Not Applicable | Recruiting | November 1, 2018 | United States, Arizona ... more >> University of Arizona Cancer Center Recruiting Tucson, Arizona, United States, 85724 Contact: Clara Curiel-Lewandroski ccuriel@email.arizona.edu Collapse << |
| NCT02282917 | Vestibular Schwannoma ... more >> Meningioma Acoustic Neuroma Neurofibromatosis Type 2 Collapse << | Early Phase 1 | Active, not recruiting | October 2022 | United States, California ... more >> Stanford University Stanford, California, United States, 94305 United States, Maryland Johns Hopkins University Baltimore, Maryland, United States, 21287 United States, Massachusetts Massachusetts Eye and Ear Boston, Massachusetts, United States, 02214 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
| NCT01562275 | Neoplasms | Phase 1 | Completed | - | United States, Massachusetts ... more >> Boston, Massachusetts, United States, 02215 United States, Michigan Detroit, Michigan, United States, 48201 United States, Tennessee Nashville, Tennessee, United States, 37203 Spain Barcelona, Spain, 08035 Valencia, Spain, 46010 Collapse << |
| NCT01473095 | Solid Tumor M... more >>alignant Lymphoma Tumor Collapse << | Phase 1 | Completed | - | United States, Alabama ... more >> Birmingham, Alabama, United States, 35294 United States, Arizona Scottsdale, Arizona, United States, 85258 United States, Florida Miami, Florida, United States, 33136 United States, Georgia Atlanta, Georgia, United States, 30322 Atlanta, Georgia, United States, 30341 United States, Indiana Lafayette, Indiana, United States, 47905 United States, Texas San Antonio, Texas, United States, 78229 Collapse << |
| NCT01625286 | Advanced or Metastatic Breast ... more >>Cancer ER+ve Advanced or Metastatic Breast Cancer Collapse << | Phase 1 Phase 2 | Active, not recruiting | March 29, 2019 | - |
| NCT02465060 | Advanced Malignant Solid Neopl... more >>asm Bladder Carcinoma Breast Carcinoma Cervical Carcinoma Colon Carcinoma Colorectal Carcinoma Endometrial Carcinoma Esophageal Carcinoma Gastric Carcinoma Glioma Head and Neck Carcinoma Kidney Carcinoma Liver and Intrahepatic Bile Duct Carcinoma Lung Carcinoma Lymphoma Malignant Uterine Neoplasm Melanoma Ovarian Carcinoma Pancreatic Carcinoma Plasma Cell Myeloma Prostate Carcinoma Rectal Carcinoma Recurrent Bladder Carcinoma Recurrent Breast Carcinoma Recurrent Cervical Carcinoma Recurrent Colon Carcinoma Recurrent Colorectal Carcinoma Recurrent Esophageal Carcinoma Recurrent Gastric Carcinoma Recurrent Glioma Recurrent Head and Neck Carcinoma Recurrent Liver Carcinoma Recurrent Lung Carcinoma Recurrent Lymphoma Recurrent Malignant Solid Neoplasm Recurrent Melanoma Recurrent Ovarian Carcinoma Recurrent Pancreatic Carcinoma Recurrent Plasma Cell Myeloma Recurrent Prostate Carcinoma Recurrent Rectal Carcinoma Recurrent Skin Carcinoma Recurrent Thyroid Gland Carcinoma Recurrent Uterine Corpus Carcinoma Refractory Lymphoma Refractory Malignant Solid Neoplasm Refractory Plasma Cell Myeloma Skin Carcinoma Thyroid Gland Carcinoma Uterine Corpus Cancer Collapse << | Phase 2 | Recruiting | - | - |
| NCT02664935 | Non-Small Cell Lung Cancer ... more >> Carcinoma, Squamous Cell Adenocarcinoma Collapse << | Phase 2 | Recruiting | September 2021 | United Kingdom ... more >> Belfast City Hospital, Belfast Health and Social Care Trust Recruiting Belfast, United Kingdom Contact: Paula Scullin Queen Elizabeth Hospital Birmingham, University Hospitals Birmingham NHS Foundation Trust Recruiting Birmingham, United Kingdom, B15 2GW Contact: Gary Middleton, MB BS MD FRCP Principal Investigator: Gary Middleton, MB BS MD FRCP Birmingham Heartlands Hospital, Heart of England NHS Foundation Trust Recruiting Birmingham, United Kingdom Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust Recruiting Cambridge, United Kingdom, CB2 0QQ Contact: David Gilligan, BSc (Hons) MB BChir FRCP FRCR cctc@addenbrookes.nhs.uk Principal Investigator: David Gilligan, BSc (Hons) MB BChir FRCP FRCR Velindre Cancer Centre, Velindre NHS Trust Recruiting Cardiff, United Kingdom, CF14 2TL Contact: Alison Brewster, BSC MB BCh FRCR MD 029 2061 5888 Principal Investigator: Alison Brewster, BSC MB BCh FRCR MD Edinburgh Cancer Centre, Western General Hospital Recruiting Edinburgh, United Kingdom, EH4 2XU Contact: Melanie Mackean, MB ChB MRCP MSc MD Principal Investigator: Melanie Mackean, MB ChB MRCP MSc MD Royal Devon and Exeter Hospital Recruiting Exeter, United Kingdom Contact: Elizabeth Toy Principal Investigator: Elizabeth Toy Cancer Research UK Clinical Trials Unit, Beatson West of Scotland Cancer Centre Recruiting Glasgow, United Kingdom, G12 0YN Contact: Noelle O'Rourke, BA MB MCh MA MCRP MD FRCR CCST Principal Investigator: Noelle O'Rourke, BA MB MCh MA MCRP MD FRCR CCST St. James' University Hospital, Leeds Teaching Hospital NHS Trust Recruiting Leeds, United Kingdom, LS9 7TF Contact: Clive Mulatero, BA MB BCh MA PhD FRCP Principal Investigator: Clive Mulatero, BA MB BCh MA PhD FRCP Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust Recruiting Leicester, United Kingdom Contact: Dean Fennell Royal Marsden Hospital, The Royal Marsden NHS Foundation Trust Recruiting London, United Kingdom, SW3 6JJ Contact: Sanjay Popat Principal Investigator: Sanjay Popat, BSc MB BS MRCP PhD FRCP Charing Cross Hospital, Imperial College Healthcare NHS Trust Recruiting London, United Kingdom Contact: Conrad Lewanski Guy's Hospital, Guy's and St Thomas' NHS Foundation Trust Recruiting London, United Kingdom Contact: James Spicer St Bartholomew's Hospital, Barts Health NHS Trust Recruiting London, United Kingdom Contact: John Conibear University College Hospital, University College London Hospitals NHS Foundation Trust Recruiting London, United Kingdom The Christie Hospital, The Christie NHS Foundation Trust Recruiting Manchester, United Kingdom Contact: Yvonne Summers Sir Bobby Robson Cancer Trial Research Centre, The Newcastle upon Tyne Hospitals Recruiting Newcastle, United Kingdom, NE7 7DN Contact: Alastair Greystoke Principal Investigator: Alastair Greystoke, BSc MBChB MRCP MSc PhD Churchill Hospital, Oxford University Hospitals NHS Foundation Trust Recruiting Oxford, United Kingdom Contact: Denis Talbot Weston Park Hospital, Sheffield Teaching Hospitals NHS Foundation Trust Recruiting Sheffield, United Kingdom Contact: Sarah Danson Southampton General Hospital, University Hospital Southampton NHS Foundation Trust Recruiting Southampton, United Kingdom, SO16 6YD Contact: Christian Ottensmeier clinicaltrials@uhs.nhs.uk Principal Investigator: Christian Ottensmeier Collapse << |
| NCT02240212 | Cancer | Phase 1 | Completed | - | Korea, Republic of ... more >> Novartis Investigative Site Seoul, Korea, Republic of, 110-774 Novartis Investigative Site Seoul, Korea, Republic of, 120/752 Novartis Investigative Site Seoul, Korea, Republic of, 135-710 Taiwan Novartis Investigative Site Taipei, Taiwan, 100 Novartis Investigative Site Taipei, Taiwan, 112 Collapse << |
| NCT03733119 | Triple Negative Breast Cancer | Phase 2 | Recruiting | October 1, 2021 | United States, Wisconsin ... more >> University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Renae Quale 608-265-2789 rmq@medicine.wisc.edu Principal Investigator: Ruth O'Regan Collapse << |
| NCT01690468 | Ovarian Cancer | Phase 1 Phase 2 | Recruiting | December 2018 | United States, Florida ... more >> H. Lee Moffitt Cancer Center and Research Institute Recruiting Tampa, Florida, United States, 33612 Contact: Denise Dorman 813-745-7272 denise.dorman@moffitt.org Sub-Investigator: Sachin Apte, M.D. Principal Investigator: Robert M. Wenham, M.D. Sub-Investigator: Mian Shahzad, M.D., Ph.D. Collapse << |
| NCT02430363 | Glioblastoma | Phase 1 Phase 2 | Unknown | June 2018 | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Belgium UCL- Cliniques Universitaires Saint Luc Brussels, Belgium Germany St Johannes Hospital Duisburg, Germany, 47166 Italy Spedali Civili di Brescia Brescia, Italy IRCCS San Raffaele Milan, Italy Poland Lower-Silesian Oncology Centre Wroclaw, Lower-Silesian, Poland, 53413 Russian Federation Pavlov State Medical University St. Petersburg, Russian Federation, 197089 Spain Hospital Universitario Germans Trias I Pujol Barcelona,, Spain Switzerland Universitätsklinik für Frauenheilkunde Bern, Switzerland Ukraine Regional Cancer Center Dnepropetrovsk, Ukraine, 49000 National Institute of Cancer Kiev, Ukraine, 03035 United Kingdom Royal Victoria Hospital Belfast, Ulster, United Kingdom, BT12 6BA Collapse << |
| NCT01555281 | Multiple Myeloma | Phase 1 Phase 2 | Active, not recruiting | December 2019 | Italy ... more >> Istituto Europeo di Oncologia IEO Milano, Italy, 20141 University of Torino Torino, Italy, 10127 Switzerland Kantonsspital Aarau Aarau, Switzerland, 5001 Kantonsspital Baden Baden, Switzerland, 5404 Istituto Oncologico Svizzera Italiana IOSI Bellinzona, Switzerland, 6500 Inselspital Bern Bern, Switzerland, 3010 Kantonsspital Graubünden Chur, Switzerland, 7000 Kantonsspital Olten Olten, Switzerland, 4600 Kantonsspital St. Gallen St. Gallen, Switzerland, 9007 Regionalspital Thun, Switzerland, 3600 UniversitätsSpital Zürich Zürich, Switzerland, 8091 Collapse << |
| NCT02476955 | Solid Tumors ... more >>Ovarian Cancer Endometrial Cancer Collapse << | Phase 1 Phase 2 | Recruiting | June 2021 | United States, Michigan ... more >> Completed Grand Rapids, Michigan, United States, 49503 United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 United States, Oklahoma University of Oklahoma Health Sciences Center Not yet recruiting Oklahoma City, Oklahoma, United States, 73104 United States, Texas MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Completed San Antonio, Texas, United States, 78229 Collapse << |
| NCT01186705 | Colon Cancer ... more >>Rectal Cancer Collapse << | Phase 2 | Terminated(Lack of accrual) | - | United States, New York ... more >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT01562275 | - | - | Completed | - | - |
| NCT01186705 | - | - | Terminated(Lack of accrual) | - | - |
| NCT02299648 | Stomach Neoplasms | Not Applicable | Recruiting | December 2019 | Korea, Republic of ... more >> Samsung Medical center Recruiting Seoul, Korea, Republic of, 135-710 Contact: Yoonjeong Ahn 82-2-2148-7395 younjeong.ahn@samsung.com Principal Investigator: Jeeyun Lee, MD,PhD Samsung Medical Center Recruiting Seoul, Korea, Republic of Contact: Jeeyun Lee, M.D., Ph.D. 82-2-3410-3459 jyun.lee@samsung.com Collapse << |
| NCT01958112 | Cervical Cancer | Phase 2 | Terminated(Drug supply) | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 Collapse << |
| NCT01147211 | Non Small Cell Lung Cancer | Phase 1 | Unknown | December 2013 | Taiwan ... more >> National Taiwan University Hospital Taipei, Taiwan, 100 Collapse << |
| NCT01138085 | Cancer | Phase 1 | Completed | - | United States, Colorado ... more >> GSK Investigational Site Aurora, Colorado, United States, 80045 United States, Connecticut GSK Investigational Site New Haven, Connecticut, United States, 06520 United States, Massachusetts GSK Investigational Site Boston, Massachusetts, United States, 02114 GSK Investigational Site Boston, Massachusetts, United States, 02215 United States, New Jersey GSK Investigational Site New Brunswick, New Jersey, United States, 08901 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37232 United States, Texas GSK Investigational Site Dallas, Texas, United States, 75246 GSK Investigational Site Houston, Texas, United States, 77230-1439 GSK Investigational Site San Antonio, Texas, United States, 78229 United States, Utah GSK Investigational Site Salt Lake City, Utah, United States, 84112-5550 Collapse << |
| NCT02121639 | Prostate Cancer | Phase 1 Phase 2 | Recruiting | December 2018 | United Kingdom ... more >> Southampton General Hospital Recruiting Southampton, Hampshire, United Kingdom, SO16 6YD Contact: Sara Moein S.Hosseini-Moein@soton.ac.uk Principal Investigator: Simon Crabb Collapse << |
| NCT01653912 | Recurrent Platinum-resistant O... more >>varian Cancer Collapse << | Phase 1 Phase 2 | Completed | - | Australia, Queensland ... more >> Royal Brisbane and Women's Hospital Herston, Queensland, Australia, 4029 Australia, Victoria Peter MacCallum Cancer Centre East Melbourne, Victoria, Australia, 8006 Western Hospital Footscray, Victoria, Australia, 3011 Royal Women's Hospital Parkville, Victoria, Australia, 3052 Australia, Western Australia Sir Charles Gairdner Hospital Nedlands, Western Australia, Australia, 6009 Russian Federation Medical Radiology Scientific Center of Ministry of Healthcare and Social Development of RF Omskaya, Russian Federation, 249036 City Clinical Oncology Dispensary Saint-Petersburg, Russian Federation, 198255 United Kingdom Mount Vernon Cancer Center Northwood, Middlesex, London, United Kingdom, HA6 2RN Royal Surrey County Hospital NHS Foundation Trust Guildford, Surry, United Kingdom, GU2 7XP Imperial College Healthcare NHS Trust London, United Kingdom, W 12 0HS Collapse << |
| NCT01593579 | - | - | Withdrawn(Planned parent study... more >> never enrolled) Collapse << | May 2016 | United States, Tennessee ... more >> Vanderbilt University Nashville, Tennessee, United States, 37232 Collapse << |
| NCT01445587 | Cancer | Phase 2 | Withdrawn(Based on the clinica... more >>l activity, not safety data, of the AKT inhibitor, GSK has decided at this time to suspend further development of GSK2110183 as monotherapy.) Collapse << | November 2011 | Australia, Victoria ... more >> GSK Investigational Site Melbourne, Victoria, Australia, 3004 Collapse << |
| NCT01971515 | Solid Tumor | Phase 1 | Completed | - | United States, Alabama ... more >> University of Alabama at Birmingham Birmingham, Alabama, United States, 35294 United States, California Cedars Sinai Medical Center Los Angeles, California, United States, 90048 University of California at San Diego, Moores Cancer Center San Diego, California, United States, 92093 United States, Florida Sylvester Comprehensive Cancer Center Miami, Florida, United States, 33136 United States, Louisiana Metairie Oncology Metairie, Louisiana, United States, 70006 United States, Massachusetts Massachusetts General Hospital Boston, Massachusetts, United States, 02114 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Henry Ford Hospital Detroit, Michigan, United States, 48202 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, New York Mount Sinai New York, New York, United States, 10029 United States, South Carolina Medical University of South Carolina Charleston, South Carolina, United States, 29425 United States, Texas Mary Crowley Cancer Research Center Dallas, Texas, United States, 75251 MD Anderson Cancer Center Houston, Texas, United States, 77030 University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 United States, Vermont Fletcher Allen Health Care, Inc. Burlington, Vermont, United States, 05401 Collapse << |
| NCT02483858 | Cancer | Phase 1 | Active, not recruiting | December 2018 | United States, Minnesota ... more >> Mayo Clinic Rochester Rochester, Minnesota, United States, 55905 United States, New York Roswell Park Cancer Buffalo, New York, United States, 14263 United States, Ohio University Hospitals of Cleveland Cleveland, Ohio, United States, 44106 United States, Texas MD Anderson Cancer Houston, Texas, United States, 77030 Spain Vall d'Hebron University Hospital Barcelona, Spain, 08035 Switzerland Basel University Hospital Basel, Switzerland, 4031 United Kingdom University College Hospital London London, United Kingdom Churchill Hospital Oxford, United Kingdom, OX3 7DQ Collapse << |
| NCT01226316 | Advanced Solid Malignancy ... more >> Safety and Tolerability Pharmacokinetics Pharmacodynamics Tumour Response Advanced or Metastatic Breast Cancer Ovarian Cancer Cervical Cancer Endometrial Cancer PIK3CA AKT1 PTEN ER Positive HER2 Positive Collapse << | Phase 1 | Recruiting | November 15, 2019 | - |
| NCT02018874 | Solid Tumors and Non-Hodgkin's... more >> Lymphoma Collapse << | Phase 1 | Completed | - | France ... more >> Gustave Roussy Villejuif, Val de Marne, France, 94805 Collapse << |
| NCT02093546 | - | - | Active, not recruiting | August 31, 2019 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01653912 | - | - | Completed | - | - |
| NCT01240928 | Metastatic Breast Cancer | Phase 1 | Withdrawn(Funding not availabl... more >>e, study did not open to accrual and will not open in future) Collapse << | - | - |
| NCT01395004 | Langerhans Cell Histiocytosis | Phase 2 | Completed | - | United States, Maryland ... more >> Johns Hopkins Hospital Baltimore, Maryland, United States, 21287 United States, Massachusetts Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Staten Island University Hospital Staten Island, New York, United States, 10305 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Collapse << |
| NCT01240941 | Metastatic Breast Cancer | Phase 2 | Withdrawn(Funding was not avai... more >>lable) Collapse << | December 2012 | - |
| NCT00881946 | Hematologic Malignancies | Phase 1 Phase 2 | Completed | - | Australia, New South Wales ... more >> Prince of Wales Hospital Sydney, New South Wales, Australia, 2031 Australia, Victoria The Alfred Hospital Melbourne, Victoria, Australia, 3004 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Korea, Republic of Seoul National University Hospital Seoul, Korea, Republic of, 110-744 Collapse << |
| NCT01235897 | - | - | Completed | - | - |
| NCT02177682 | Neoplasms, Haematologic | Phase 1 | Active, not recruiting | December 28, 2018 | Japan ... more >> Novartis Investigative Site Aichi, Japan, 467-8602 Novartis Investigative Site Fukuoka, Japan, 811-1395 Novartis Investigative Site Miyagi, Japan, 980-8574 Novartis Investigative Site Niigata, Japan, 951-8566 Novartis Investigative Site Tokyo, Japan, 104-0045 Collapse << |
| NCT01235897 | Advanced Solid Tumors ... more >> Tumors Cancer Collapse << | Phase 1 | Completed | - | United States, California ... more >> University of California, San Francisco San Francisco, California, United States, 94115 Collapse << |
| NCT01428492 | Multiple Myeloma | Phase 1 | Completed | - | United States, Arizona ... more >> Novartis Investigative Site Scottsdale, Arizona, United States, 85259 United States, California Novartis Investigative Site Duarte, California, United States, 91010 United States, Georgia Novartis Investigative Site Atlanta, Georgia, United States, 30322 United States, Illinois Novartis Investigative Site Chicago, Illinois, United States, 60637 United States, New York Novartis Investigative Site New York, New York, United States, 10029 United States, North Carolina Novartis Investigative Site Chapel Hill, North Carolina, United States, 27599-7305 United States, Ohio Novartis Investigative Site Columbus, Ohio, United States, 43210 United States, Wisconsin Novartis Investigative Site Madison, Wisconsin, United States, 53792 Australia, Victoria Novartis Investigative Site Melbourne, Victoria, Australia, 3004 Canada, British Columbia Novartis Investigative Site Vancouver, British Columbia, Canada, V5Z 1M9 Canada, Ontario Novartis Investigative Site Toronto, Ontario, Canada, M5G 2M9 Ireland Novartis Investigative Site Galway, Ireland Taiwan Novartis Investigative Site Taipei, Taiwan, 100 Collapse << |
| NCT01333475 | - | - | Completed | - | - |
| NCT02040480 | Cancer | Phase 1 | Completed | - | Australia, New South Wales ... more >> GSK Investigational Site Randwick, New South Wales, Australia, 2031 Collapse << |
| NCT01333475 | Colorectal Neoplasms | Phase 2 | Completed | - | United States, Maryland ... more >> National Institutes of Health Clinical Center, 9000 Rockville Pike Bethesda, Maryland, United States, 20892 Collapse << |
| NCT01827644 | Cancer | Phase 1 | Completed | - | Australia, Victoria ... more >> GSK Investigational Site Melbourne, Victoria, Australia, 3004 Collapse << |
| NCT01941927 | Melanoma | Phase 2 | Unknown | May 2016 | United States, California ... more >> UCSF Helen Diller Family Comprehensive Cancer Center San Francisco, California, United States, 94115 United States, New York Memorial Sloan-Kettering Cancer Center New York City, New York, United States, 10065 Collapse << |
| NCT03017521 | Solid Tumor, Adult | Phase 2 | Recruiting | December 2020 | Korea, Republic of ... more >> Severance Hospital, Yonsei University Health System Recruiting Seoul, Korea, Republic of, 03722 Contact: Minkyu Jung Collapse << |
| NCT02423603 | Metastatic Breast Cancer | Phase 2 | Active, not recruiting | December 2018 | - |
| NCT01239355 | - | - | Terminated(Early termination f... more >>or discouraging results) Collapse << | - | - |
| NCT00896207 | Healthy, no Evidence of Diseas... more >>e Collapse << | Phase 1 | Completed | - | United States, Minnesota ... more >> Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse << |
| NCT01979523 | Recurrent Uveal Melanoma ... more >> Stage IV Uveal Melanoma AJCC v7 Collapse << | Phase 2 | Completed | - | United States, Georgia ... more >> Emory University Hospital/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, New York Columbia University/Herbert Irving Cancer Center New York, New York, United States, 10032 Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Tennessee Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 France Institut Curie Paris Paris, France, 75005 United Kingdom The University of Liverpool Liverpool, United Kingdom, L69 3GA Collapse << |
| NCT01319539 | Estrogen Receptor Negative ... more >> Estrogen Receptor Positive HER2/Neu Negative HER2/Neu Positive Progesterone Receptor Negative Progesterone Receptor Positive Stage IA Breast Cancer Stage IB Breast Cancer Stage IIA Breast Cancer Stage IIB Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Triple-Negative Breast Carcinoma Collapse << | Phase 2 | Terminated(terminated early, d... more >>ue to toxicity) Collapse << | - | United States, New York ... more >> Columbia University Medical Center New York, New York, United States, 10032 Albert Einstein College of Medicine The Bronx, New York, United States, 10461 Montefiore Medical Center - Moses Campus The Bronx, New York, United States, 10467-2490 Collapse << |
| NCT01239355 | Adult Hepatocellular Carcinoma... more >> Advanced Adult Hepatocellular Carcinoma Localized Non-Resectable Adult Liver Carcinoma Recurrent Adult Liver Carcinoma Collapse << | Phase 2 | Terminated(Early termination f... more >>or discouraging results) Collapse << | - | United States, California ... more >> Tower Cancer Research Foundation Beverly Hills, California, United States, 90211-1850 City of Hope Medical Center Duarte, California, United States, 91010 USC Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 Decatur Memorial Hospital Decatur, Illinois, United States, 62526 NorthShore University HealthSystem-Evanston Hospital Evanston, Illinois, United States, 60201 Ingalls Memorial Hospital Harvey, Illinois, United States, 60426 Joliet Oncology-Hematology Associates Limited Joliet, Illinois, United States, 60435 Loyola University Medical Center Maywood, Illinois, United States, 60153 Illinois CancerCare-Peoria Peoria, Illinois, United States, 61615 Central Illinois Hematology Oncology Center Springfield, Illinois, United States, 62702 Southern Illinois University Springfield, Illinois, United States, 62702 United States, Indiana Fort Wayne Medical Oncology and Hematology Inc-Parkview Fort Wayne, Indiana, United States, 46845 Northern Indiana Cancer Research Consortium South Bend, Indiana, United States, 46628 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Michigan University of Michigan Ann Arbor, Michigan, United States, 48109 Oncology Care Associates PLLC Saint Joseph, Michigan, United States, 49085 United States, Missouri Saint John's Mercy Medical Center Saint Louis, Missouri, United States, 63141 United States, Ohio Arthur G. James Cancer Hospital and Solove Research Institute at Ohio State University Medical Center Columbus, Ohio, United States, 43210 United States, Pennsylvania Penn State Milton S Hershey Medical Center Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Pittsburgh, Pennsylvania, United States, 15232 Collapse << |
| NCT01263145 | Adult Solid Neoplasm ... more >> Recurrent Breast Carcinoma Stage IV Breast Cancer Collapse << | Phase 1 | Completed | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02215 United States, Tennessee Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01776008 | Estrogen Receptor Positive ... more >> HER2/Neu Negative Recurrent Breast Carcinoma Stage IIA Breast Cancer Stage IIB Breast Cancer Stage IIIA Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Collapse << | Phase 2 | Terminated(Study did not pass ... more >>Stage 1 interim analysis.) Collapse << | - | United States, Arizona ... more >> Mayo Clinic in Arizona Scottsdale, Arizona, United States, 85259 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Iowa University of Iowa/Holden Comprehensive Cancer Center Iowa City, Iowa, United States, 52242 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Metro Minnesota Community Oncology Research Consortium Saint Louis Park, Minnesota, United States, 55416 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Collapse << |
| NCT02338622 | Advanced Cancer | Phase 1 | Unknown | October 2015 | United Kingdom ... more >> Northern Institute for Cancer, Freeman Hospital Recruiting Newcastle, Newcastle upon Tyne, United Kingdom, NE7 7DN Contact: Elizabeth R Plummer, MD +44(0)191 213844 ruth.plummer@newcastle.ac.uk Principal Investigator: Elizabeth R Plummer, MD Royal Marsden NHS Foundation Trust Recruiting Sutton, Surrey, United Kingdom, SM2 5PT Contact: Timothy A Yap, PhD 0208 661 3539 timothy.yap@icr.ac.uk Principal Investigator: Timothy A Yap, PhD Collapse << |
| NCT01425879 | Advanced Adult Hepatocellular ... more >>Carcinoma Localized Non-Resectable Adult Liver Carcinoma Recurrent Adult Liver Carcinoma Recurrent Gallbladder Carcinoma Stage IV Distal Bile Duct Cancer Stage IV Gallbladder Cancer Unresectable Extrahepatic Bile Duct Carcinoma Unresectable Gallbladder Carcinoma Collapse << | Phase 2 | Completed | - | United States, California ... more >> USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 United States, District of Columbia MedStar Georgetown University Hospital Washington, District of Columbia, United States, 20007 United States, Georgia Emory University/Winship Cancer Institute Atlanta, Georgia, United States, 30322 United States, North Carolina University of North Carolina at Chapel Hill Chapel Hill, North Carolina, United States, 27599 United States, Ohio Seidman Cancer Center at University Hospitals Case Medical Center, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44106 Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01776008 | - | - | Terminated(Study did not pass ... more >>Stage 1 interim analysis.) Collapse << | - | - |
| NCT00666081 | Cancer | Phase 1 | Withdrawn(Study Cancelled befo... more >>re enrollment) Collapse << | December 2009 | - |
| NCT01425879 | - | - | Completed | - | - |
| NCT01319539 | - | - | Terminated(terminated early, d... more >>ue to toxicity) Collapse << | - | - |
| NCT02208375 | Breast Cancer ... more >> Malignant Female Reproductive System Neoplasm Collapse << | Phase 1 Phase 2 | Active, not recruiting | November 2021 | United States, Texas ... more >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01658943 | Pancreatic Acinar Cell Carcino... more >>ma Pancreatic Ductal Adenocarcinoma Recurrent Pancreatic Carcinoma Stage IV Pancreatic Cancer Collapse << | Phase 2 | Completed | - | - |
| NCT01658943 | - | - | Completed | - | - |
| NCT01344031 | Estrogen Receptor Positive ... more >> Invasive Breast Carcinoma Recurrent Breast Carcinoma Stage IV Breast Cancer AJCC v6 and v7 Collapse << | Phase 1 | Completed | - | United States, Missouri ... more >> Washington University School of Medicine Saint Louis, Missouri, United States, 63110 Collapse << |
| NCT01859182 | Adenocarcinoma of the Gallblad... more >>der Adenocarcinoma With Squamous Metaplasia of the Gallbladder Adult Primary Cholangiocellular Carcinoma Advanced Adult Primary Liver Cancer Cholangiocarcinoma of the Extrahepatic Bile Duct Localized Unresectable Adult Primary Liver Cancer Metastatic Extrahepatic Bile Duct Cancer Recurrent Adult Primary Liver Cancer Recurrent Extrahepatic Bile Duct Cancer Stage II Gallbladder Cancer Stage IIIA Gallbladder Cancer Stage IIIB Gallbladder Cancer Stage IVA Gallbladder Cancer Stage IVB Gallbladder Cancer Unresectable Extrahepatic Bile Duct Cancer Collapse << | Phase 2 | Withdrawn | - | - |
| NCT01266954 | Solid Tumours | Phase 1 | Completed | - | United Kingdom ... more >> GSK Investigational Site London, United Kingdom, W12 0HS Collapse << |
| NCT01531894 | Cancer | Phase 2 | Completed | - | United States, Maryland ... more >> Novartis Investigative Site Baltimore, Maryland, United States, 21231 United States, Massachusetts Novartis Investigative Site Boston, Massachusetts, United States, 02115 United States, New York Novartis Investigative Site New York, New York, United States, 10029 Novartis Investigative Site New York, New York, United States, 10065 Australia, Victoria Novartis Investigative Site Melbourne, Victoria, Australia, 3004 Canada, Ontario Novartis Investigative Site Toronto, Ontario, Canada, M5G 1Z6 Ireland Novartis Investigative Site Galway, Ireland Korea, Republic of Novartis Investigative Site Seoul, Korea, Republic of, 110-744 Collapse << |
| NCT01239342 | Metastatic Renal Cell Cancer ... more >> Recurrent Renal Cell Carcinoma Stage IV Renal Cell Cancer Collapse << | Phase 2 | Active, not recruiting | December 31, 2017 | United States, California ... more >> Tower Cancer Research Foundation Beverly Hills, California, United States, 90211-1850 City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Pennsylvania Penn State Hershey Cancer Institute-Clinical Trials Office Hershey, Pennsylvania, United States, 17033-0850 University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01369849 | - | - | Completed | - | - |
| NCT01251861 | Recurrent Prostate Carcinoma ... more >> Stage I Prostate Cancer AJCC v7 Stage IIA Prostate Cancer AJCC v7 Stage IIB Prostate Cancer AJCC v7 Stage III Prostate Cancer AJCC v7 Collapse << | Phase 2 | Active, not recruiting | - | - |
| NCT01369849 | Chronic Lymphocytic Leukemia ... more >> Recurrent Small Lymphocytic Lymphoma Refractory Chronic Lymphocytic Leukemia Collapse << | Phase 1 Phase 2 | Completed | - | - |
| NCT01705340 | Adenocarcinoma of the Gastroes... more >>ophageal Junction HER2-positive Breast Cancer Male Breast Cancer Recurrent Breast Cancer Recurrent Esophageal Cancer Recurrent Gastric Cancer Stage IIIC Breast Cancer Stage IIIC Esophageal Cancer Stage IIIC Gastric Cancer Stage IV Breast Cancer Stage IV Esophageal Cancer Stage IV Gastric Cancer Collapse << | Phase 1 | Terminated | - | United States, New York ... more >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Collapse << |
| NCT01239342 | - | - | Active, not recruiting | - | - |
| NCT01935973 | Endometrial Adenocarcinoma ... more >> Endometrial Clear Cell Adenocarcinoma Endometrial Mixed Adenocarcinoma Endometrial Serous Adenocarcinoma Endometrial Undifferentiated Carcinoma Recurrent Uterine Corpus Carcinoma Collapse << | Phase 1 | Active, not recruiting | - | - |
| NCT01802320 | Colon Mucinous Adenocarcinoma ... more >> Colon Signet Ring Cell Adenocarcinoma Rectal Mucinous Adenocarcinoma Rectal Signet Ring Cell Adenocarcinoma Recurrent Colon Carcinoma Recurrent Rectal Carcinoma Stage IIIA Colon Cancer Stage IIIA Rectal Cancer Stage IIIB Colon Cancer Stage IIIB Rectal Cancer Stage IIIC Colon Cancer Stage IIIC Rectal Cancer Stage IVA Colon Cancer Stage IVA Rectal Cancer Stage IVB Colon Cancer Stage IVB Rectal Cancer Collapse << | Phase 2 | Active, not recruiting | December 2017 | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT02077569 | Invasive Breast Cancer | Phase 2 | Completed | - | United Kingdom ... more >> Royal Derby Hospital Derby, Derbyshire, United Kingdom, DE22 3DT Plymouth Hospitals NHS Trust Derriford, Plymouth, Devon, United Kingdom, PL6 8DH Royal Bournemouth Hospital Bournemouth, Dorset, United Kingdom, BH7 7DW Poole Hospital NHS Foundation Trust Poole, Dorset, United Kingdom, BH15 2JB Leicester Royal Infirmary Leicester, Leicestershire, United Kingdom, LE1 5WW Western General Hospital Edinburgh, Lothian, United Kingdom, EH4 2XU Royal Liverpool University Hospital Liverpool, Merseyside, United Kingdom, L7 8XP Kingsmill Hospital Sutton-in-Ashfield, Nottinghamshire, United Kingdom, NG17 4JL Sheffield Cancer Research Centre Sheffield, South Yorkshire, United Kingdom, S10 2SJ University Hospital Birmingahm Birmingham, West Midlands, United Kingdom, B15 2TT Leeds St James Institue of Oncology Leeds, West Yorkshire, United Kingdom, LS9 7TF Collapse << |
| NCT01802320 | - | - | Active, not recruiting | - | - |
| NCT01481129 | Diffuse Large B Cell Lymphoma | Phase 2 | Completed | - | France ... more >> Hopitaux de Paris Vellefaux, Paris, France, 75010 Institut Bergonie Cancer Center Bordeaux, France, 33076 Henri Mondor University-Hospital Center Creteil, France, 94000 Hospital Claude Huriez Chru Lille, France, 59037 Centre Leon Berard Lyon, France, 69373 Institut Paoli Calmettes Marseille, France, 13273 Hopital Saint Louis Paris, France, 75010 Centre Hospitalier Lyon-Sud Pierre Benite, France, 69310 Institut Gustave Roussy Villejuif, France, 94805 Collapse << |
| NCT01260701 | Adenocarcinoma of the Gastroes... more >>ophageal Junction Diffuse Gastric Adenocarcinoma Gastric Intestinal Type Adenocarcinoma Gastric Mixed Adenocarcinoma Recurrent Gastric Carcinoma Collapse << | Phase 2 | Completed | - | - |
| NCT01481129 | - | - | Completed | - | - |
| NCT01294306 | Adenosquamous Lung Carcinoma ... more >> Bronchioloalveolar Carcinoma Large Cell Lung Carcinoma Lung Adenocarcinoma Recurrent Non-Small Cell Lung Carcinoma Squamous Cell Lung Carcinoma Collapse << | Phase 2 | Completed | - | United States, California ... more >> Tower Cancer Research Foundation Beverly Hills, California, United States, 90211-1850 City of Hope Comprehensive Cancer Center Duarte, California, United States, 91010 USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 City of Hope South Pasadena South Pasadena, California, United States, 91030 United States, Illinois University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Pennsylvania University of Pittsburgh Cancer Institute (UPCI) Pittsburgh, Pennsylvania, United States, 15232 Collapse << |
| NCT00493818 | Cancer | Phase 1 | Terminated | - | United States, Indiana ... more >> GSK Investigational Site Indianapolis, Indiana, United States, 46202 United States, Michigan GSK Investigational Site Detroit, Michigan, United States, 48201 United States, North Carolina GSK Investigational Site Durham, North Carolina, United States, 27710 Collapse << |
| NCT01258998 | Adult Nasal Type Extranodal NK... more >>/T-cell Lymphoma Anaplastic Large Cell Lymphoma Angioimmunoblastic T-cell Lymphoma B-cell Adult Acute Lymphoblastic Leukemia B-cell Chronic Lymphocytic Leukemia Cutaneous B-cell Non-Hodgkin Lymphoma Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue Hepatosplenic T-cell Lymphoma Intraocular Lymphoma Nodal Marginal Zone B-cell Lymphoma Noncutaneous Extranodal Lymphoma Peripheral T-cell Lymphoma Recurrent Adult Acute Lymphoblastic Leukemia Recurrent Adult Diffuse Large Cell Lymphoma Recurrent Adult Diffuse Mixed Cell Lymphoma Recurrent Adult Diffuse Small Cleaved Cell Lymphoma Recurrent Adult Grade III Lymphomatoid Granulomatosis Recurrent Adult Hodgkin Lymphoma Recurrent Adult Immunoblastic Large Cell Lymphoma Recurrent Adult Lymphoblastic Lymphoma Recurrent Adult T-cell Leukemia/Lymphoma Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Refractory Hairy Cell Leukemia Small Intestine Lymphoma Splenic Marginal Zone Lymphoma T-cell Adult Acute Lymphoblastic Leukemia T-cell Large Granular Lymphocyte Leukemia Testicular Lymphoma Waldenström Macroglobulinemia Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01294306 | - | - | Completed | - | - |
| NCT01260701 | - | - | Completed | - | - |
| NCT01989598 | Recurrent Plasma Cell Myeloma ... more >> Refractory Plasma Cell Myeloma Collapse << | Phase 2 | Active, not recruiting | - | Canada, Alberta ... more >> Foothills Hospital Calgary, Alberta, Canada, T2N 2T9 Tom Baker Cancer Centre Calgary, Alberta, Canada, T2N 4N2 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, Ontario Kingston Health Sciences Centre Kingston, Ontario, Canada, K7L 2V7 University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse << |
| NCT01480154 | Adult Solid Neoplasm ... more >> Hormone-Resistant Prostate Carcinoma Recurrent Melanoma Recurrent Prostate Carcinoma Recurrent Renal Cell Carcinoma Stage IIIA Cutaneous Melanoma AJCC v7 Stage IIIB Cutaneous Melanoma AJCC v7 Stage IIIC Cutaneous Melanoma AJCC v7 Stage IV Cutaneous Melanoma AJCC v6 and v7 Stage IV Prostate Cancer AJCC v7 Stage IV Renal Cell Cancer AJCC v7 Collapse << | Phase 1 | Active, not recruiting | - | United States, New Jersey ... more >> Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 Collapse << |
| NCT01964924 | Estrogen Receptor Negative ... more >> HER2/Neu Negative Invasive Breast Carcinoma Progesterone Receptor Negative Recurrent Breast Carcinoma Stage IV Breast Cancer Triple-Negative Breast Carcinoma Collapse << | Phase 2 | Active, not recruiting | - | United States, District of Col... more >>umbia MedStar Georgetown University Hospital Washington, D.C., District of Columbia, United States, 20007 United States, Florida Moffitt Cancer Center Tampa, Florida, United States, 33612 United States, New York Roswell Park Cancer Institute Buffalo, New York, United States, 14263 United States, North Carolina UNC Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 United States, Ohio Case Western Reserve University Cleveland, Ohio, United States, 44106 Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Virginia Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Collapse << |
| NCT01307631 | Endometrial Adenocarcinoma ... more >> Endometrial Adenosquamous Carcinoma Endometrial Clear Cell Adenocarcinoma Endometrial Serous Adenocarcinoma Recurrent Uterine Corpus Carcinoma Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Massachusetts General Hospital Charlestown, Massachusetts, United States, 02129 Newton-Wellesley Hospital Newton, Massachusetts, United States, 02462 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01258998 | - | - | Completed | - | - |
| NCT01245205 | HER2-positive Breast Cancer ... more >> Male Breast Cancer Recurrent Breast Cancer Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Unspecified Adult Solid Tumor, Protocol Specific Collapse << | Phase 1 | Completed | - | United States, South Dakota ... more >> Sanford Cancer Center-Oncology Clinic Sioux Falls, South Dakota, United States, 57104 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Collapse << |
| NCT01349933 | Recurrent Squamous Cell Carcin... more >>oma of the Nasopharynx Stage IV Squamous Cell Carcinoma of the Nasopharynx Collapse << | Phase 2 | Completed | - | United States, Iowa ... more >> University of Iowa Hospitals and Clinics Iowa City, Iowa, United States, 52242 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 Metro-Minnesota CCOP Saint Louis Park, Minnesota, United States, 55416 United States, Missouri Washington University School of Medicine Saint Louis, Missouri, United States, 63110 China, Hong Kong Chinese University of Hong Kong-Prince of Wales Hospital Shatin, Hong Kong, China, OX1 3UJ Singapore National University Hospital Singapore, Singapore, 119074 National Cancer Centre Singapore, Singapore, 169610 Johns Hopkins Singapore International Medical Centre Singapore, Singapore, 308433 Collapse << |
| NCT01307631 | - | - | Completed | - | - |
| NCT01604772 | Recurrent Oral Cavity Adenoid ... more >>Cystic Carcinoma Recurrent Salivary Gland Carcinoma Salivary Gland Adenoid Cystic Carcinoma Stage IVA Major Salivary Gland Cancer AJCC v7 Stage IVA Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Stage IVB Major Salivary Gland Cancer AJCC v7 Stage IVB Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Stage IVC Major Salivary Gland Cancer AJCC v7 Stage IVC Oral Cavity Adenoid Cystic Carcinoma AJCC v6 and v7 Collapse << | Phase 2 | Completed | - | - |
| NCT01604772 | - | - | Completed | - | - |
| NCT00920257 | Cancer | Phase 1 | Completed | - | United States, Maryland ... more >> GSK Investigational Site Baltimore, Maryland, United States, 21231-2410 United States, Massachusetts GSK Investigational Site Boston, Massachusetts, United States, 02115 United States, New York GSK Investigational Site New York, New York, United States, 10021 United States, Oklahoma GSK Investigational Site Oklahoma City, Oklahoma, United States, 73104 United States, Tennessee GSK Investigational Site Nashville, Tennessee, United States, 37203 United States, Texas GSK Investigational Site Houston, Texas, United States, 77030 Canada, Ontario GSK Investigational Site Toronto, Ontario, Canada, M5G 2M9 Collapse << |
| NCT01231919 | Accelerated Phase Chronic Myel... more >>ogenous Leukemia Acute Leukemias of Ambiguous Lineage Acute Myeloid Leukemia/Transient Myeloproliferative Disorder Acute Undifferentiated Leukemia Aggressive NK-cell Leukemia Atypical Chronic Myeloid Leukemia, BCR-ABL1 Negative Blastic Phase Chronic Myelogenous Leukemia Blastic Plasmacytoid Dendritic Cell Neoplasm Childhood Burkitt Lymphoma Childhood Chronic Myelogenous Leukemia Childhood Diffuse Large Cell Lymphoma Childhood Grade III Lymphomatoid Granulomatosis Childhood Immunoblastic Large Cell Lymphoma Childhood Nasal Type Extranodal NK/T-cell Lymphoma Chronic Eosinophilic Leukemia Chronic Myelomonocytic Leukemia Chronic Neutrophilic Leukemia Chronic Phase Chronic Myelogenous Leukemia Intraocular Lymphoma Juvenile Myelomonocytic Leukemia Mast Cell Leukemia Myeloid/NK-cell Acute Leukemia Noncutaneous Extranodal Lymphoma Post-transplant Lymphoproliferative Disorder Primary Central Nervous System Hodgkin Lymphoma Primary Central Nervous System Non-Hodgkin Lymphoma Progressive Hairy Cell Leukemia, Initial Treatment Prolymphocytic Leukemia Recurrent Childhood Acute Lymphoblastic Leukemia Recurrent Childhood Acute Myeloid Leukemia Recurrent Childhood Anaplastic Large Cell Lymphoma Recurrent Childhood Grade III Lymphomatoid Granulomatosis Recurrent Childhood Large Cell Lymphoma Recurrent Childhood Lymphoblastic Lymphoma Recurrent Childhood Small Noncleaved Cell Lymphoma Recurrent Grade 1 Follicular Lymphoma Recurrent Grade 2 Follicular Lymphoma Recurrent Grade 3 Follicular Lymphoma Recurrent Mantle Cell Lymphoma Recurrent Marginal Zone Lymphoma Recurrent Mycosis Fungoides/Sezary Syndrome Recurrent Small Lymphocytic Lymphoma Recurrent/Refractory Childhood Hodgkin Lymphoma Refractory Chronic Lymphocytic Leukemia Refractory Hairy Cell Leukemia Relapsing Chronic Myelogenous Leukemia Secondary Acute Myeloid Leukemia Small Intestine Lymphoma Splenic Marginal Zone Lymphoma Unspecified Childhood Solid Tumor, Protocol Specific Waldenström Macroglobulinemia Collapse << | Phase 1 | Completed | - | - |
| NCT01253447 | - | - | Completed | - | - |
| NCT01349933 | - | - | Completed | - | - |
| NCT01283035 | Ovarian Sarcoma ... more >> Recurrent Fallopian Tube Carcinoma Recurrent Ovarian Carcinoma Recurrent Primary Peritoneal Carcinoma Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States, 02114 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 Newton-Wellesley Hospital Newton, Massachusetts, United States, 02462 United States, New York Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01253447 | Adult Acute Megakaryoblastic L... more >>eukemia (M7) Adult Acute Minimally Differentiated Myeloid Leukemia (M0) Adult Acute Monoblastic Leukemia (M5a) Adult Acute Monocytic Leukemia (M5b) Adult Acute Myeloblastic Leukemia With Maturation (M2) Adult Acute Myeloblastic Leukemia Without Maturation (M1) Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities Adult Acute Myeloid Leukemia With Del(5q) Adult Acute Myeloid Leukemia With Inv(16)(p13;q22) Adult Acute Myeloid Leukemia With t(16;16)(p13;q22) Adult Acute Myeloid Leukemia With t(8;21)(q22;q22) Adult Acute Myelomonocytic Leukemia (M4) Adult Erythroleukemia (M6a) Adult Pure Erythroid Leukemia (M6b) Recurrent Adult Acute Myeloid Leukemia Collapse << | Phase 2 | Completed | - | United States, Texas ... more >> UT MD Anderson Cancer Center Houston, Texas, United States, 77030 United States, Washington Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium Seattle, Washington, United States, 98109 Collapse << |
| NCT01519427 | Recurrent Melanoma ... more >> Stage IIIA Melanoma Stage IIIB Melanoma Stage IIIC Melanoma Stage IV Melanoma Collapse << | Phase 2 | Terminated(Study terminated du... more >>e to slow accrual) Collapse << | - | United States, Georgia ... more >> Emory University Atlanta, Georgia, United States, 30322 United States, New Jersey Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Tennessee Vanderbilt-Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Virginia Virginia Commonwealth University/Massey Cancer Center Richmond, Virginia, United States, 23298 Collapse << |
| NCT01283035 | - | - | Completed | - | - |
| NCT01519427 | - | - | Terminated(Study terminated du... more >>e to slow accrual) Collapse << | - | - |
| NCT01281163 | Estrogen Receptor Negative ... more >> Estrogen Receptor Positive HER2/Neu Positive Progesterone Receptor Negative Progesterone Receptor Positive Recurrent Breast Carcinoma Stage IV Breast Cancer Collapse << | Phase 1 | Terminated | - | United States, Connecticut ... more >> Yale University New Haven, Connecticut, United States, 06520 United States, Massachusetts Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 Wayne State University/Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Tennessee Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232 Collapse << |
| NCT01783171 | Pancreatic Adenocarcinoma ... more >> Recurrent Pancreatic Carcinoma Stage III Pancreatic Cancer AJCC v6 and v7 Stage IV Pancreatic Cancer AJCC v6 and v7 Unresectable Pancreatic Carcinoma Collapse << | Phase 1 | Completed | - | United States, Colorado ... more >> University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 University of Colorado Denver, Colorado, United States, 80217-3364 United States, Maryland Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 United States, Wisconsin University of Wisconsin Hospital and Clinics Madison, Wisconsin, United States, 53792 Canada, Ontario University Health Network-Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 Collapse << |
| NCT01277757 | - | - | Completed | - | - |
| NCT01277757 | Recurrent Breast Carcinoma ... more >> Stage IIIB Breast Cancer Stage IIIC Breast Cancer Stage IV Breast Cancer Collapse << | Phase 2 | Completed | - | United States, Massachusetts ... more >> Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 United States, New York Columbia University/Herbert Irving Cancer Center New York, New York, United States, 10032 United States, Tennessee Vanderbilt University/Ingram Cancer Center Nashville, Tennessee, United States, 37232 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01907815 | Recurrent Adult Acute Myeloid ... more >>Leukemia Untreated Adult Acute Myeloid Leukemia Collapse << | Phase 2 | Terminated(Lack of efficacy.) | - | United States, Illinois ... more >> University of Chicago Comprehensive Cancer Center Chicago, Illinois, United States, 60637 United States, Maryland University of Maryland/Greenebaum Cancer Center Baltimore, Maryland, United States, 21201 United States, Texas M D Anderson Cancer Center Houston, Texas, United States, 77030 Collapse << |
| NCT01902173 | Adult Solid Neoplasm ... more >> Recurrent Colon Carcinoma Recurrent Melanoma Recurrent Ovarian Carcinoma Stage IIIC Colon Cancer Stage IIIC Ovarian Cancer Stage IIIC Skin Melanoma Stage IV Skin Melanoma Collapse << | Phase 1 Phase 2 | Suspended(Temporarily stopped ... more >>for assessment. Contact ctsucontact@westat.com for specifics) Collapse << | - | United States, California ... more >> USC / Norris Comprehensive Cancer Center Los Angeles, California, United States, 90033 UCLA / Jonsson Comprehensive Cancer Center Los Angeles, California, United States, 90095 California Pacific Medical Center-Pacific Campus San Francisco, California, United States, 94115 UCSF Medical Center-Mount Zion San Francisco, California, United States, 94115 United States, Colorado University of Colorado Cancer Center - Anschutz Cancer Pavilion Aurora, Colorado, United States, 80045 United States, Michigan University of Michigan Comprehensive Cancer Center Ann Arbor, Michigan, United States, 48109 United States, Ohio Cleveland Clinic Foundation Cleveland, Ohio, United States, 44195 Ohio State University Comprehensive Cancer Center Columbus, Ohio, United States, 43210 United States, Oregon Clackamas Radiation Oncology Center Clackamas, Oregon, United States, 97015 Providence Milwaukie Hospital Milwaukie, Oregon, United States, 97222 Providence Newberg Medical Center Newberg, Oregon, United States, 97132 Providence Willamette Falls Medical Center Oregon City, Oregon, United States, 97045 Providence Portland Medical Center Portland, Oregon, United States, 97213 Providence Saint Vincent Medical Center Portland, Oregon, United States, 97225 Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Washington PeaceHealth Southwest Medical Center Vancouver, Washington, United States, 98664 Collapse << |
| NCT01476137 | Cancer | Phase 1 | Completed | - | United States, Texas ... more >> GSK Investigational Site Dallas, Texas, United States, 75246 GSK Investigational Site San Antonio, Texas, United States, 78229 Collapse << |
| NCT01907815 | - | - | Terminated(Lack of efficacy.) | - | - |
