CAS No.: 2378173-15-8
PF-06928215 Catalog No. CSN23557
Synonyms: PF-06928215
PF-06928215 is a cyclic GMP-AMP synthase (cGAS) inhibitor with IC50 of 4.9 μM in the presence of 1 mM ATP, 0.3 mM GTP, 100 nM 45-bp interferon-stimulatory dsDNA (ISD).
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 作用机制
- 参考文献
- [1] Hall J, Brault A, Vincent F, et al. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017;12(9):e0184843.
- [2] Hall J, Brault A, Vincent F, Weng S, Wang H, Dumlao D, Aulabaugh A, Aivazian D, Castro D, Chen M, Culp J, Dower K, Gardner J, Hawrylik S, Golenbock D, Hepworth D, Horn M, Jones L, Jones P, Latz E, Li J, Lin LL, Lin W, Lin D, Lovering F, Niljanskul N, Nistler R, Pierce B, Plotnikova O, Schmitt D, Shanker S, Smith J, Snyder W, Subashi T, Trujillo J, Tyminski E, Wang G, Wong J, Lefker B, Dakin L, Leach K. Discovery of PF-06928215 as a high affinity inhibitor of cGAS enabled by a novel fluorescence polarization assay. PLoS One. 2017 Sep 21;12(9):e0184843. doi: 10.1371/journal.pone.0184843
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 2378173-15-8 | 储存条件 |
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| 分子式 | C20H20N4O4 | 运输 | 蓝冰 | |
| 分子量 | 380.40 | 别名 | PF-06928215 |
