CAS No.: 1398583-31-7
PF-05105679 Catalog No. CSN20615
Synonyms: PF-5105679
PF-05105679 is an orally-bioavailable and selective TRPM8 blocker (IC50 = 103 nM) which exhibits > 100-fold selectivity for TRPM8 over a panel of receptors, ion channels and enzymes, including TRPV1 and TRPA1 ion channels.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT01393652 Healthy Volunteers Phase 1 Completed - Belgium ... more >> Pfizer Investigational Site Bruxelles, Belgium, B-1070 Collapse << - 参考文献
- [1] Andrews MD, et al. Discovery of a Selective TRPM8 Antagonist with Clinical Efficacy in Cold-Related Pain. ACS Med Chem Lett. 2015 Jan 30;6(4):419-24.
- [2] Winchester WJ, Gore K, et al. Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans. J Pharmacol Exp Ther. 2014 Nov;351(2):259-69.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1398583-31-7 | 储存条件 |
|
|
| 分子式 | C26H21FN2O3 | 运输 | 蓝冰 | |
| 分子量 | 428.46 | 别名 | PF-5105679 |
