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CAS No.: 100299-08-9

Pemirolast potassium/吡嘧司特钾 Catalog No. CSN11668

Synonyms: TWT-8152;BMY 26517;Pemirolast (potassium salt)

Pemirolast potassium is an antagonist of histamine H1 and mast cell stabilizer with antiallergic effect.

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技术信息

生物活性

描述Pemirolast potassium is an antiallergic drug with high safety. Pemirolast potassium 1 and 10 mg/kg markedly inhibited proteinuria in the reversible model. In the irreversible model, pemirolast potassium 3 mg/kg showed a significant decrease in the incidence of glomerulosclerosis. In chronic glomerulonephritis patients, pemirolast potassium, 10 mg twice daily, for 6 months, significantly reduced the severity of proteinuria^[3]. Twice-daily administration of pemirolast potassium was as efficacious and safe as twice-daily nedocromil sodium in the 8-week treatment of ragweed allergic conjunctivitis and was superior to nedocromil in comfort^[4]. Pemirolast potassium, an antiallergic agent, has preventive effects against restenosis after percutaneous transluminal coronary angioplasty (PTCA)^[5]. Levocabastine and pemirolast inhibited histamine release from the rat conjunctiva in correlation with a decrease in histamine content in tears. A potentiating effect induced by the simultaneous use of levocabastine and pemirolast may be attributable to the antihistaminic activity of levocabastine and histamine release inhibition by levocabastine and pemirolast^[6]. As an antiallergic drug, pemirolast potassium (TBX) at concentrations between 0.01 and 10 micrograms/ml inhibited antigen (Ag)-stimulated degranulation in RBL-2H3 cells, which have the properties of mucosal mast cells^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02609334	Asthma	Phase 2	Completed	-	Denmark ... more >> Hvidovre Hospital Hvidovre, Denmark, 2650 Bisbebjerg Hospital København NV, Denmark, 2400 Collapse <<
NCT03119714	Allergic Asthma	Phase 2	Recruiting	April 2018	Sweden ... more >> Lung and Allergy Research Unit C2-88 Karolinska University Hospital Huddinge Recruiting Stockholm, Sweden, 14186 Contact: Barbro Dahlén, MD,PhD +46858586785 barbro.dahlen@ki.se Contact: Nikolaos Lazarinis, MD +46768760476 nikolaos.lazarinis@ki.se Collapse <<
NCT02517372	Healthy Volunteers	Phase 1	Completed	-	-

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参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7552 mL
- 18.7758 mL
- 37.5516 mL
- 5 mM
- 0.7510 mL
- 3.7552 mL
- 7.5103 mL
- 10 mM
- 0.3755 mL
- 1.8776 mL
- 3.7552 mL

技术信息

CAS号

100299-08-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H7KN6O

运输

蓝冰

分子量

266.30

别名

TWT-8152;BMY 26517;Pemirolast (potassium salt);TBX;Pemirolast;吡嘧司特钾

溶解度

DMSO	15.0 mg/mL (56.3 mM) warming
Water	80.0 mg/mL (300.4 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT02609334	Asthma	Phase 2	Completed	-	Denmark ... more >> Hvidovre Hospital Hvidovre, Denmark, 2650 Bisbebjerg Hospital København NV, Denmark, 2400 Collapse <<
NCT03119714	Allergic Asthma	Phase 2	Recruiting	April 2018	Sweden ... more >> Lung and Allergy Research Unit C2-88 Karolinska University Hospital Huddinge Recruiting Stockholm, Sweden, 14186 Contact: Barbro Dahlén, MD,PhD +46858586785 barbro.dahlen@ki.se Contact: Nikolaos Lazarinis, MD +46768760476 nikolaos.lazarinis@ki.se Collapse <<
NCT02517372	Healthy Volunteers	Phase 1	Completed	-	-
NCT02615080	Asthma	Phase 2	Completed	-	Bulgaria ... more >> MHAT St. Ivan Rilski-2003 Ltd., Department of Internal Medicine Dupnitsa, Bulgaria, 2600 SHATPPD - Pazardzhik EOOD, Department of phthisiatrics pneumonia and pulmonary functional diagnostics Pazardzhik, Bulgaria, 4400 Medical Center - Razgrad OOD, Office of Pneumonology and Phthisiatry Razgrad, Bulgaria, 7200 Medical Center Smolyan OOD, Office of Clinical Allergology Smolyan, Bulgaria, 4700 First MHAT - Sofia EAD, Third Department of Internal Medicine Sofia, Bulgaria, 1000 MHAT Lyulin EAD, Department of Internal Medicine Sofia, Bulgaria, 1336 SHATPPD Vratsa Ltd, Department of Pneumology Vratza, Bulgaria, 3000 Denmark Aalborg Universitetshospital Aalborg, Denmark, 9000 Hvidovre Hospital Hvidovre, Denmark, 2650 Bisbebjerg Hospital København NV, Denmark, 2400 Næstved Sygehus, Lungemedinsk afdeling Næstved, Denmark, 4700 Regionshospitalet Silkeborg Silkeborg, Denmark, 8600 Poland Centrum Badań Klinicznych PI-House Sp. Z O.O. Gdańsk, Poland, 80-546 Medica Pro Familia Katowice, Poland, 40-954 NZOZ Centrum Medcyczne ProMiMed Kraków, Poland, 31-637 Medica Pro Familia Krákow, Poland, 30-002 Clinical Best Solution Lublin, Poland, 20-045 NZOZ ALERGO-MED. Specjalistyczna Przychodnia Lekarska Poznan, Poland, 60-823 Medica Pro Familia Warszawa, Poland, 01-868 Centrum Medyczne Oporów Wroclaw, Poland, 52-416 United Kingdom The Medicines Evaluation Unit (MEU) Ltd Manchester, United Kingdom, M23 9QZ Medinova North London Clinical Studies Center Northwood, United Kingdom, HA6 2RN Medinova East London Clinical Studies Centre Romford, United Kingdom, RM1 3LT Medinova South London Clinical Studies Centre Sidcup, United Kingdom, DA14 6LT Collapse <<

Pemirolast potassium/吡嘧司特钾 Catalog No. CSN11668

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