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CAS No.: 944118-01-8
Synonyms: ASP015K;JNJ-54781532
Peficitinb is an oral Janus kinase (JAK) inhibitor. Peficitinib inhibits JAK1, JAK2, JAK3 and Tyk2 enzyme activities with IC50s of 3.9, 5.0, 0.71 and 4.8 nM, respectively, and has moderate selectivity for JAK3 inhibition.
生物活性
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|---|---|---|---|---|
NCT01959282 | Colitis, Ulcerative | Phase 2 | Completed | - | - |
NCT01747564 | Healthy Subjects ... more >> Plasma Concentration of Mirabegron Collapse << | Phase 1 | Completed | - | Japan ... more >> Kyushu, Japan Collapse << |
NCT02603497 | Patients With Impaired Renal F... more >>unction Collapse << | Phase 1 | Completed | - | Japan ... more >> Site JP00001 Tokyo, Japan Site JP00002 Tokyo, Japan Collapse << |
实验方案
技术信息
CAS号 | 944118-01-8 | 储存条件 |
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分子式 | C18H22N4O2 | 运输 | 蓝冰 | |||||
分子量 | 326.39 | 别名 | ASP015K;JNJ-54781532 | |||||
溶解度 |
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动物实验配方 |
NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
---|
NCT01959282 | Colitis, Ulcerative | Phase 2 | Completed | - | - |
NCT01747564 | Healthy Subjects ... more >> Plasma Concentration of Mirabegron Collapse << | Phase 1 | Completed | - | Japan ... more >> Kyushu, Japan Collapse << |
NCT02603497 | Patients With Impaired Renal F... more >>unction Collapse << | Phase 1 | Completed | - | Japan ... more >> Site JP00001 Tokyo, Japan Site JP00002 Tokyo, Japan Collapse << |
NCT02586194 | Patients With Impaired Hepatic... more >> Function Collapse << | Phase 1 | Completed | - | Japan ... more >> Site JP00001 Fukuoka, Japan Site JP00003 Kanagawa, Japan Site JP00002 Tokyo, Japan Site JP00004 Tokyo, Japan Site JP00005 Tokyo, Japan Site JP00006 Tokyo, Japan Collapse << |
NCT01649999 | Arthritis, Rheumatoid | Phase 2 | Completed | - | Japan ... more >> Chubu, Japan Chugoku, Japan Hokkaido, Japan Kansai, Japan Kantou, Japan Kyushu, Japan Touhoku, Japan Collapse << |
NCT01096862 | Psoriasis | Phase 2 | Completed | - | United States, Alabama ... more >> Total Skin & Beauty Dermatology Center Birmingham, Alabama, United States, 35205 United States, California Therapeutics Clinical Research San Diego, California, United States, 92123 United States, Florida FXM Research, Corp. Miami, Florida, United States, 33175 Renstar Medical Research Ocala, Florida, United States, 34471 United States, Kentucky Derm Research, PLLC Louisville, Kentucky, United States, 40217 United States, Oregon Oregon Medical Research Center Portland, Oregon, United States, 97223 United States, South Carolina Palmetto Clinical Trial Services Greenville, South Carolina, United States, 29607 United States, Tennessee Rivergate Dermatology Goodlettsville, Tennessee, United States, 37072 United States, Texas J & S Studies College Station, Texas, United States, 77845 United States, Virginia Virginia Clinical Research Norfolk, Virginia, United States, 23507 United States, Wisconsin Madison Skin & Research, Inc Madison, Wisconsin, United States, 53719 Collapse << |
NCT01364974 | Healthy Subjects ... more >> Pharmacokinetics of ASP015K Pharmacodynamics Collapse << | Phase 1 | Completed | - | United States, Minnesota ... more >> DaVita Clinical Research Minneapolis, Minnesota, United States, 55404 Collapse << |
NCT01387087 | Healthy Subjects ... more >> Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Clinical Pharmacology of Miami Miami, Florida, United States, 33014 United States, Minnesota Prism Research St. Paul, Minnesota, United States, 55114 Collapse << |
NCT01430065 | Pharmacokinetics of ASP015K ... more >> Drug Interactions Healthy Subjects Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Clinical Pharmacology of Miami Miami, Florida, United States, 33014 Collapse << |
NCT01430078 | Healthy | Phase 1 | Completed | - | United Kingdom ... more >> Quotient Clinical Limited Ruddington, Nottingham, United Kingdom, NG116JS Collapse << |
NCT01190670 | Healthy Pharm... more >>acokinetics of ASP015K and Tacrolimus Collapse << | Phase 1 | Completed | - | United States, Hawaii ... more >> Honolulu, Hawaii, United States, 96813 Collapse << |
NCT01754805 | Rheumatoid Arthritis | Phase 1 | Completed | - | United States, Alabama ... more >> Anniston, Alabama, United States, 36207 Collapse << |
NCT01711814 | Arthritis, Rheumatoid | Phase 2 | Completed | - | - |
NCT01225224 | Healthy Volunteer ... more >> Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | Japan ... more >> Kyushu, Japan Collapse << |
NCT01554696 | Arthritis, Rheumatoid | Phase 2 | Completed | - | - |
NCT01565655 | Arthritis, Rheumatoid | Phase 2 | Completed | - | - |
NCT01364987 | Healthy Subjects ... more >> Drug Interactions Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Clinical Pharmacology of Miami Miami, Florida, United States, 33014 Collapse << |
NCT01182077 | Healthy Pharm... more >>acokinetics of ASP015K and Midazolam Collapse << | Phase 1 | Completed | - | United States, Florida ... more >> Miami, Florida, United States, 33014 Collapse << |
NCT01484964 | Pharmacokinetics of ASP015K ... more >> Bioavailability of ASP015K Healthy Subjects Collapse << | Phase 1 | Completed | - | United States, California ... more >> PAREXEL Glendale, California, United States, 91206 Collapse << |
NCT02531191 | Healthy Volunteers | Phase 1 | Completed | - | Japan ... more >> Tokyo, Japan Collapse << |
NCT02308163 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT01686217 | Pharmacokinetics of ASP015K ... more >> Food Effect Healthy Volunteers Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Parexel International Baltimore, Maryland, United States, 21225 Collapse << |
NCT02760342 | Healthy Subjects | Phase 1 | Completed | - | Japan ... more >> Site JP00001 Kagoshima, Japan Collapse << |
NCT02305849 | Rheumatoid Arthritis | Phase 3 | Completed | - | - |
NCT01406132 | Healthy Subjects ... more >> Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | United States, Wisconsin ... more >> Covance Clinical Research Unit (CCRU) Madison, Wisconsin, United States, 53704 Collapse << |
NCT01959399 | Healthy Subjects ... more >> Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | United States, California ... more >> PAREXEL - Early Phase Unit Glendale, California, United States, 91206 Collapse << |
NCT03660059 | Rheumatoid Arthritis (RA) | Phase 3 | Recruiting | August 2022 | China ... more >> Site CN00058 Recruiting Inner Mongolia, China Site CN00047 Recruiting Shantou, China Site CN00059 Recruiting Wuhan, China Site CN00049 Recruiting Zhuzhou, China Korea, Republic of Site KR00037 Recruiting Gwangju, Korea, Republic of Site KR00036 Recruiting Incheon, Korea, Republic of Site KR00033 Recruiting Seoul, Korea, Republic of Site KR00034 Recruiting Seoul, Korea, Republic of Site KR00035 Recruiting Seoul, Korea, Republic of Taiwan Site TW00025 Recruiting Taipei, Taiwan Site TW00026 Recruiting Taipei, Taiwan Collapse << |
NCT01638013 | Arthritis, Rheumatoid | Phase 3 | Active, not recruiting | March 2020 | - |
NCT01486017 | Bioavailability of ASP015K ... more >> Pharmacokinetics of ASP015K Healthy Subjects Collapse << | Phase 1 | Completed | - | United States, Texas ... more >> Covance Dallas, Texas, United States, 75247 Collapse << |
NCT01929577 | Bioavailability of ASP015K ... more >> Healthy Subjects Pharmacokinetics of ASP015K Food Effect of ASP015K Collapse << | Phase 1 | Completed | - | United States, Maryland ... more >> Parexel - Early Phase Clinical Unit Baltimore, Maryland, United States, 21225 Collapse << |
NCT02111317 | Healthy Subjects ... more >> Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | United States, California ... more >> PAREXEL Glendale, California, United States, 91206 Collapse << |
NCT02141425 | Healthy Volunteers ... more >> Pharmacokinetics of ASP015K Collapse << | Phase 1 | Completed | - | United States, California ... more >> California Clinical Trials Medical Group/Parexel Glendale, California, United States, 91206 Collapse << |
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