|6,7-二甲氧基-4-[N-(3-溴苯基)氨基]喹唑啉盐酸盐|CsnPharm

CAS No.: 183322-45-4

Synonyms: SU-5271 Hydrochloride;AG1517 Hydrochloride;ZM 252868 Hydrochloride

PD153035 HCl is an reversible inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM.

规格	价格	促销价格	库存	数量

400-920-2911

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400-920-2911

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靶点 EGFR

IC50:29pM
描述Many of the tyrosine kinase enzymes which are early components of the growth signal transduction pathway in mammalian cells are encoded by proto-oncogenes, and their transformation or overexpression has been shown to occur in a large percentage of clinical cancers. The epidermal growth factor receptor (EGFR), one of the tyrosine kinase enzymes, has thus become important target for cancer therapy. PD153035 is a potent and selective inhibitor against EGFR with an IC₅₀ value of 25 pM and K_i value of 6 pM. PD153035 inhibited EGF-stimulated receptor autophosphorylation in A431 human epidermoid carcinoma cells, with IC₅₀ of 14 nM . In cell lines with the highest level of EGFR overexpression, PD153035 concentrations of ≥ 75 nM resulted in complete inhibition of receptor autophosphorylation. PD153035 caused a dose-dependent growth inhibition of EGFR-positive cell lines, beginning at less than micromolar concentrations, and the IC₅₀ was less than 1 μM in most cases .
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CAS号	183322-45-4	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C16H15BrClN3O2	运输	蓝冰
分子量	396.67	别名	SU-5271 Hydrochloride;AG1517 Hydrochloride;ZM 252868 Hydrochloride;SU-5271 HCl;ZM-252868 HCl;PD 153035 (hydrochloride);AG-1517;PD-153035;PD153035 HCl;PD153035 hydrochloride

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