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CAS No.: 950762-95-5
Synonyms: PCI-34051
PCI-34051 is a potent and specific HDAC8 inhibitor with IC50 of 10 nM in a cell-free assay. It has greater than 200-fold selectivity over HDAC1 and 6, more than 1000-fold selectivity over HDAC2, 3, and 10.
实验方案
技术信息
CAS号 | 950762-95-5 | 储存条件 |
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分子式 | C17H16N2O3 | 运输 | 蓝冰 | |||||||||||
分子量 | 296.32 | 别名 | PCI-34051 | |||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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human Huh7 cells | - | Function assay | 3 days | Antiviral activity against HCV genotype 1b infected in human Huh7 cells after 3 days by luciferase reporter gene assay, EC50=1.8 μM | 25490700 |
human Jurkat cells | - | Growth inhibition assay | 72 h | Growth inhibition of human Jurkat cells incubated for 72 hrs by MTS assay, GI50=11 μM | 23116147 |
human MT2 cells | - | Growth inhibition assay | 72 h | Growth inhibition of human MT2 cells incubated for 72 hrs by MTS assay, GI50=15 μM | 23116147 |
human MT4 cells | - | Growth inhibition assay | 72 h | Growth inhibition of human MT4 cells incubated for 72 hrs by MTS assay, GI50=25 μM | 23116147 |
human NB-1 cells | - | Growth inhibition assay | 72 h | Growth inhibition of human NB-1 cells incubated for 72 hrs by MTS assay, GI50=14 μM | 23116147 |
靶点 | Description | IC50 |
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HDAC8 | IC50:10nM |
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