CAS No.: 269718-84-5
Pardoprunox Catalog No. CSN18174
Synonyms: SLV-308;DU-126891;SME-308
Pardoprunox is a partial dopamine D2 (pKi = 8.1) and D3 (pKi = 8.6) receptor agonist (IA = 50% and 67%, respectively) and full serotonin 5-HT1A (pKi = 8.5) receptor agonist (IA = 100%), and also binds to D4 (pKi = 7.8), α1-adrenergic (pKi = 7.8), α2-adrenergic (pKi = 7.4), and 5-HT7 receptors (pKi = 7.2) with lower affinity.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点 NCT00335166 Early Stage Parkinson Disease Phase 3 Completed - - NCT00269516 Early Stage Parkinson's Diseas... more >>e Collapse << Phase 3 Completed - - NCT00406588 Advanced Stage Parkinson's Dis... more >>ease Collapse << Phase 3 Completed - - - 更多
- 参考文献
- [1] Bronzova J, Sampaio C, et al. Double-blind study of pardoprunox, a new partial dopamine agonist, in early Parkinson's disease. Mov Disord. 2010 Apr 30;25(6):738-46.
- [2] Glennon JC, Van Scharrenburg G, et al. In vitro characterization of SLV308(7-[4-methyl-1-piperazinyl] -2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 269718-84-5 | 储存条件 |
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| 分子式 | C12H15N3O2 | 运输 | 蓝冰 | |
| 分子量 | 233.27 | 别名 | SLV-308;DU-126891;SME-308 |
