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CAS No.: 27113-22-0

Paradol/姜酮酚 Catalog No. CSN18175

Synonyms: [6]-Gingerone;[6]-Paradol;(6)-Paradol

Paradol is an effective inhibitor of tumor promotion in mouse skin carcinogenesis, binds to cyclooxygenase (COX)-2 active site, it's a pungent phenolic substance isolated and purified from ginger and other Zingiberaceae plants.

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生物活性

描述Paradols are non-pungent and biotransformed metabolites of shogaols and reduce inflammatory responses as well as oxidative stress as shogaols. Pretreatment with 6-paradol (paradol derivatives) reduced neuroinflammatory responses in LPS-stimulated BV2 microglia by a concentration-dependent manner^[3]. ^[6]-Paradol, a pungent phenolic compound present in certain Zingiberaceae plants, is known to have antimicrobial and analgesic activities. ^[6]-Paradol can attenuate promotion of skin carcinogenesis and TPA-induced ear edema in female ICR mice, and to induce apoptosis in cultured human promyelocytic leukemia (HL-60) cells^[4]. Once-daily administration of 6-shogaol and 6-paradol (5 mg/kg/day, p.o.) to symptomatic EAE (experimental autoimmune encephalomyelitis) mice significantly alleviated clinical signs of the disease along with remyelination and reduced cell accumulation in the white matter of spinal cord^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03591822	Moderate to Severe Dementia	Not Applicable	Not yet recruiting	January 2020	France ... more >> Résidence Mutualiste " L'adret " Not yet recruiting Bellegarde En Forez, France, 42210 Contact: Christèle DECOT + 33 4 77 54 47 18 cdecot@mutualite-loire.com Résidence Mutualiste " Les Tilleuls " Not yet recruiting La Grand Croix, France, 43320 Contact: Marie-Christine DIANA, MD + 33 4 77 73 26 93 mcdiana@mutualite-loire.com Hôpital Broca Not yet recruiting Paris, France, 75013 Contact: Anne-Sophie RIGAUD, MD, PhD + 33 1 44 08 35 03 Résidence Mutualiste " La Cerisaie " Not yet recruiting Saint Etienne, France, 42000 Contact: Philippe TERRAT, MD + 33 4 77 74 28 44 pterrat@mutualite-loire.com Résidence Mutualiste " Marie Lagrevol " Not yet recruiting Saint-just-malmont, France, 43240 Contact: Maryline MOUNIER + 33 4 77 35 61 61 mmounier@mutualite-loire.com Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.5921 mL
- 17.9606 mL
- 35.9213 mL
- 5 mM
- 0.7184 mL
- 3.5921 mL
- 7.1843 mL
- 10 mM
- 0.3592 mL
- 1.7961 mL
- 3.5921 mL

技术信息

CAS号

27113-22-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H26O3

运输

蓝冰

分子量

278.39

别名

[6]-Gingerone;[6]-Paradol;(6)-Paradol;姜酮酚

溶解度

DMSO	140.0 mg/mL (502.9 mM)

动物实验配方

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Paradol/姜酮酚 Catalog No. CSN18175

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