|(3-氨基-1-羟基丙烷-1,1-二基)二膦酸|CsnPharm

CAS No.: 40391-99-9

Pamidronicacid/帕米膦酸 Catalog No. CSN11650

Synonyms: Amidronate;帕米膦酸

Pamidronic Acid is a an amino- bisphosphonate used to prevent bone loss and treat osteoporosis.

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生物活性

描述Pamidronic acid is a drug used to treat a broad spectrum of bone absorption diseases. Osteosarcoma cell viability decreased significantly in a concentration- and time-dependent manner at pamidronate concentrations ranging from 100 to 1000 microM, most consistently after 48 and 72 hours' exposure^[3]. Pamidronate disodium 1, 5, and 10 μg/ml were unfavorable for BMMSC growth (P < .05), whereas 0.1 and 0.5 μg/mL did not affect BMMSC growth (P ≥ .05). Pamidronate disodium 0.5 μg/mL decreased the expression of genes and proteins involved in Wnt and β-catenin signaling. Pamidronate disodium inhibited Wnt and β-catenin signaling, which controls osteogenic differentiation in BMMSCs. Wnt3a, a Wnt and β-catenin signaling activator, reversed the negative effects caused by pamidronate disodium to salvage the osteogenic defect in BMMSCs (bone marrow mesenchymal stem cells)^[4]. PAM (Pamidronic Acid) can significantly inhibit and even reverse early osteoarthritic subchondral bone loss, thus alleviating the process of cartilaginous degeneration^[5]. Intravenous APD (pamidronic acid) administration appears to be an effective and safe treatment of the severe hypercalcemia due to parathyroid carcinoma^[6].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.2541 mL
- 21.2703 mL
- 42.5406 mL
- 5 mM
- 0.8508 mL
- 4.2541 mL
- 8.5081 mL
- 10 mM
- 0.4254 mL
- 2.1270 mL
- 4.2541 mL

技术信息

CAS号

40391-99-9

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C3H11NO7P2

运输

蓝冰

分子量

235.07

别名

Amidronate;帕米膦酸

溶解度

DMSO	Insoluble
Water	2.0 mg/mL (8.5 mM) warming

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