|十六酸甲酯|CsnPharm

CAS No.: 112-39-0

Synonyms: Methyl hexadecanoate;C16:0 Methyl ester;棕榈酸甲酯

Palmitic acid methyl ester is a fatty acid methyl ester with acaricidal activity, it could be found in many plants.

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400-920-2911

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生物活性

描述Palmitic acid methyl ester (PAME) is a potent vasodilator first identified and released from the superior cervical ganglion. PAME can enhance CBF (cerebral blood flow) under normal physiological conditions, while administration of PAME (0.02 mg/kg) immediately after cardiopulmonary resuscitation can also enhance CBF in vivo. Additionally, functional learning and spatial memory assessments (via T-maze) 3 days after asphyxial cardiac arrest (ACA) suggest that PAME-treated rats have improved learning and memory recovery versus ACA alone. Furthermore, improved neuronal survival in the CA1 region of the hippocampus were observed in PAME-treated, ACA-induced rats^[1]. PAME significantly reduced the levels of G2/M phase regulatory proteins, cyclin-dependent kinase 1 (Cdk1), and cyclin B1 and inhibited proliferation in hBM-MSCs. PAME also induced intracellular acidosis and increased intracellular Ca2+ levels. Moreover, the half-life of p53 protein was prolonged in the PAME-treated hBM-MSCs^[2]. Kv7 channels are involved in the anti-contractile effects of PVAT (Perivascular adipose tissue) on arterial tone in both rat aorta and human mesenteric arteries. PAME could contribute to PVAT relaxations by activating Kv7 channels in rat aorta, but not in human mesenteric arteries^[3].
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技术信息

CAS号	112-39-0	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C17H34O2	运输	蓝冰
分子量	270.45	别名	Methyl hexadecanoate;C16:0 Methyl ester;棕榈酸甲酯

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