|草酰乙酸|CsnPharm

CAS No.: 328-42-7

草酰乙酸 Catalog No. CSN23240

Synonyms: 2-Oxosuccinic acid;Oxaloacetic Acid;NSC 284205

Oxaloacetic Acid substrate for malate dehydrogenase and oxaloacetate decarboxylase. Oxaloacetic Acid is an inhibitor of SDH.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Oxaloacetic acid is an oxodicarboxylic acid that is succinic acid bearing a single oxo group. It has a role as a metabolite. It is an oxo dicarboxylic acid and a C4-dicarboxylic acid. It derives from a succinic acid. It is a conjugate acid of an oxaloacetate (2-). It is an intermediate of the tricarboxylic acid cycle. It reacts with acetyl coenzyme A to form citrate catalyzed by citrate synthase. It is also involved in gluconeogenesis, urea cycle, glyoxylic acid cycle, amino acid synthesis and fatty acid synthesis^[1]. Moreover, a low pyruvate concentration, that alone was not enough to drive respiration, was sufficient to metabolize OAA to citrate and completely reverse the loss of succinate-supported respiration at high [ADP]. Further, chemical or genetic inhibition of pyruvate uptake prevented OAA clearance and preserved respiration^[2]. Oxaloacetic acid was competitive inhibitors of succinic acid transport, and all induced proton movements that followed Michaelis-Menten kinetics^[3].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02836184	Hyperphosphatemia	Phase 4	Unknown	September 2016	China, Jiangxi ... more >> Jiujiang NO.1 People's Hospital Recruiting Jiujiang, Jiangxi, China, 332000 Collapse <<
NCT03341117	Diabetes Mellitus, Type 2 ... more >> Antioxidant Enzyme System Collapse <<	Phase 3	Completed	-	-
NCT03768245	Obesity Diabe... more >>tes Mellitus, Type 2 Cardiovascular Function Kidney Diseases Liver Diseases Physical Fitness Collapse <<	Not Applicable	Completed	-	Mexico ... more >> Hospital Regional Adolfo Lopez Matelos Mexico City, Distrito Federal, Mexico, 01620 Collapse <<

更多
参考文献

[1] Shibata K. Urinary Excretion of 2-Oxo Acids Is Greater in Rats with Streptozotocin-Induced Diabetes. J Nutr Sci Vitaminol (Tokyo). 2018;64(4):292-295
[2] Fink BD, Bai F, Yu L, Sheldon RD, Sharma A, Taylor EB, Sivitz WI. Oxaloacetic acid mediates ADP-dependent inhibition of mitochondrial complex II-driven respiration. J Biol Chem. 2018 Dec 21;293(51):19932-19941
[3] Côrte-Real M, Leão C. Transport of malic acid and other dicarboxylic acids in the yeast Hansenula anomala. Appl Environ Microbiol. 1990 Apr;56(4):1109-13

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 7.5717 mL
- 37.8583 mL
- 75.7165 mL
- 5 mM
- 1.5143 mL
- 7.5717 mL
- 15.1433 mL
- 10 mM
- 0.7572 mL
- 3.7858 mL
- 7.5717 mL

技术信息

CAS号

328-42-7

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C4H4O5

运输

蓝冰

分子量

132.07

别名

2-Oxosuccinic acid;Oxaloacetic Acid;NSC 284205;NSC 77688;OAA;Oxalacetic Acid;草酰乙酸;草乙酸

溶解度

DMSO	98.0 mg/mL (742.0 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

草酰乙酸 Catalog No. CSN23240

靶点选择性

请登录您的专属账户

确认信息