|1-(6-氯-5-(三氟甲基)吡啶-2-基)哌嗪|CsnPharm

CAS No.: 132834-56-1

Org-12962 Catalog No. CSN27303

Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively.Org-12962 displays antiaversive effects in a rat model of panic-like anxiety.

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技术信息

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描述Org-12962 is a potent, selective and orally active 5-HT2C receptor agonist with a pEC50 value of 7.01. Org-12962 also exhibits high effacy for the 5-HT2A and 5-HT2B receptor with pEC50s of 6.38 and 6.28, respectively. Org-12962 (intraperitoneal injection; 0.3-3.2 mg/kg) significantly increases the postinjection frequency thresholds for self-interruption (F3.71=11.40). Org-12962 is dissolved or microsuspended in 0.3% v/v Tween 80 in physiological saline (NaCl 0.9%)^[4]. Org-12962 displays antiaversive effects in a rat model of panic-like anxiety. As a simulation of acute anxiety with relevance to panic disorder, the selective activation of 5HT2C receptors by Ro 60-0175, Org 12962 or Ro 60-0332 induces effects analogous to those observed following benzodiazepine receptor activation by antipanic agents such as clonazepam or alprazolam or following non-selective and indirect 5HT receptor activation by fluoxetine^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.7642 mL
- 18.8209 mL
- 37.6417 mL
- 5 mM
- 0.7528 mL
- 3.7642 mL
- 7.5283 mL
- 10 mM
- 0.3764 mL
- 1.8821 mL
- 3.7642 mL

技术信息

CAS号

132834-56-1

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C10H11ClF3N3

运输

蓝冰

分子量

265.66

别名

溶解度

DMSO	240.0 mg/mL (903.4 mM) warming

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