生物活性

• 描述CC-223 is a potent mTOR kinase inhibitor (IC50=16 nM), with > 150-fold sensitivity over the related lipid kinase PI3Kα (IC50=4 μM).
• 细胞研究
• Cell Data

  Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
  human PC3 cells	-	Function assay	1 h	Inhibition of mTORC2 in human PC3 cells assessed as inhibition of Akt phosphorylation at S473 after 1 hr, IC50=0.01 μM	26083478
  human PC3 cells	-	Function assay	1 h	Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hr	26083478
  human PC3 cells	-	Function assay	1 h	Inhibition of mTORC1 in human PC3 cells assessed as inhibition of S6 phosphorylation after 1 hr	26083478

• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03591965	Hepatocellular Carcinoma	Phase 2	Recruiting	July 1, 2021	China, Heilongjiang ... more >> Oncology Hospital of Haerbin Medical University Not yet recruiting Harbin, Heilongjiang, China, 150000 Contact: Yuxian Bai       bai_yuxian@126.com    China, Jiangsu China People PLA 81 Hospital Not yet recruiting Nanjing, Jiangsu, China, 210000 Contact: Shukui Qin    86-25-80864748    qinsk@csco.org.cn    China The first Hospital of Jilin University Not yet recruiting Changchun, China Contact: Wei Li       jdyylw@163.com    Hunan Province Oncology Hospital Not yet recruiting Changsha, China Contact: Sahnzhi Gu       105575191@qq.com    Daping Hospital Not yet recruiting Chongqing, China Contact: Dong Wang       Dongwang64@hotmail.com    The first hospital of Chongqing medical university Not yet recruiting Chongqing, China Contact: Chengyou Du       duchengyou@126.com    Xiehe Hospital of Fujian Medical University Not yet recruiting Fuzhou, China Contact: Xiaoyan Lin       13950482366@qq.com    Nanfang Hospital of Nanfang Medical University Not yet recruiting Guangzhou, China Contact: Yabing Guo       gyabing@126.com    The first affiliated Hospital of Zhejiang University Not yet recruiting Hangzhou, China Contact: Weijia Fang       weijiafang@163.com    Zhejiang Province Oncology Hospital Not yet recruiting Hangzhou, China Contact: Jieer Ying       jieerying@aliyun.com    The first affiliated hospital of Anhui medical university Not yet recruiting Hefei, China Contact: Kangsheng Gu       13805692145@163.com    The second affiliated hospital of Anhui medical university Not yet recruiting Hefei, China Contact: Zhengdong Chen       chenzhendong@csco.org.cn    The first affiliated hospital of Guangxi Medical University Not yet recruiting Nanning, China Contact: Xiaohua Hu       gxykdhxh@sina.com    Oncology Hospital of Fudan University Not yet recruiting Shanghai, China Contact: Zhiqiang Meng       mengfudan2018@yeah.net    Zhongshan Hospital of Fudan University Not yet recruiting Shanghai, China Contact: Zhenggang Ren       ren.zhenggeng@zs-hospital.sh.cn    China PLA general hospital of Shenyang Not yet recruiting Shenyang, China Contact: Zhengdong Zheng          Contact       mylonzzdong@163.com    Tangdu Hospital of China PLA fourth medical university Not yet recruiting Xi'an, China Contact: Helong Zhang       zhanghelong@medmail.com.cn    Korea, Republic of Dong-A University Hospital Not yet recruiting Busan, Korea, Republic of Contact: Nan-ji Ha    82 51 240 2588       Pusan National Univ. Hospital Not yet recruiting Busan, Korea, Republic of Contact: Jung hee Bark    82 51 240 7079       Kyungpook National Univ. Hospital Not yet recruiting Daegu, Korea, Republic of Contact: Hye-ran Kim    82 53 200 6357       Severance Hospital Recruiting Seoul, Korea, Republic of, 03722 Contact: Kwang-Hyub Han          Asan Medical Center Not yet recruiting Seoul, Korea, Republic of Contact: Hye-min Lee    82 2 3010 6280       Seoul National University Hospital Recruiting Seoul, Korea, Republic of Contact: Min-kyoung Kim    82 2 2072 7450       Severance Hospital, Yonsei University Health System Not yet recruiting Seoul, Korea, Republic of Contact: Jung-hee Park          Taiwan China Medical University Hospital Recruiting Taichung, Taiwan Contact: Chang-Fang Chiu    04-22053366 ext 5022    d5686@mail.cmuh.org.tw    National Taiwan University Hospital Not yet recruiting Taipei, Taiwan Contact: Pei-Jer Chen    02-2312-3456 ext 67072    peijerchen@ntu.edu.tw    Taipei Medical University Hospital Recruiting Taipei, Taiwan Contact: Wei-Yu Kao    02-2737 2181 ext 3577    121021@tmuh.org.tw    Taipei Veterans General Hospital Recruiting Taipei, Taiwan Contact: Yee Chao    02-28757618    ychao@vghtpe.gov.tw    Chang Gung Memorial Hospital-Linkuo Recruiting Taoyuan, Taiwan Contact: Tsai-Sheng Yang    03-328-1200 ext 8825    a481124@adm.cgmh.org.tw Collapse <<
  NCT01545947	Carcinoma, Non-Small-Cell Lung... more >> Non-Small Cell Lung Cancer Collapse <<	Phase 1	Completed	-	United States, California ... more >> Cedars Sinai Medical Center, Inflammatory Bowel Disease Center Los Angeles, California, United States, 90048 University of California, San Francisco San Francisco, California, United States, 9411 United States, New York NYU School of Medicine New York, New York, United States, 10016 United States, South Carolina Cancer Center of the Carolinas Greenville, South Carolina, United States, 29605 United States, Tennessee Henry-Joyce Cancer Clinic Nashville, Tennessee, United States, 37232-5505 United States, Texas Mary Crowley Cancer Research Centers - Medical City Dallas, Texas, United States, 75201 The University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 Spain Vall d´Hebron University Hospital Barcelona, Spain, 08035 Hospital Virgen del RocíoServicio de Hematologia Sevilla, Spain, 41013 Collapse <<
  NCT02031419	Lymphoma, Large B-Cell, Diffus... more >>e Collapse <<	Phase 1	Active, not recruiting	November 30, 2020	United States, California ... more >> Sansum Clinic Santa Barbara, California, United States, 93105 Stanford Cancer Center Stanford, California, United States, 94305 United States, Colorado Rocky Mountain Cancer Centers, LLP [Boulder-COBO] Boulder, Colorado, United States, 80303 United States, Connecticut Yale Cancer Center New Haven, Connecticut, United States, 06510 United States, Florida H. Lee Moffitt Cancer Cencer and Research Institute Tampa, Florida, United States, 33612 United States, Illinois Northwestern University, Division of Hematology Oncology, Dept. of Medicine Chicago, Illinois, United States, 60611 Illinois Cancer Specialists Niles, Illinois, United States, 60714 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 United States, Oregon Willamette Valley Cancer Center Eugene, Oregon, United States, 97401-8122 United States, Tennessee West Cancer Center Germantown, Tennessee, United States, 38138 Sarah Cannon Cancer Center Nashville, Tennessee, United States, 37203 United States, Texas MD Anderson Cancer Center Houston, Texas, United States, 77030-400 United States, Wisconsin University of Wisconsin Osteoporosis Clinical Center and Research Program Madison, Wisconsin, United States, 53792 Canada, Alberta Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, Ontario Princess Margaret Hospital Toronto, Ontario, Canada, M5G 2M9 France Institut Bergonie Centre Regional de Lutte Contre Le Cancer de Bordeaux Et Sud Ouest Bordeaux, France, 33076 Centre Leon Berard Lyon, France, 69373 Institut Gustave Roussy Villejuif Cedex, France, 94805 Italy Istituto Nazionale Dei Tumori Milano, Italy, 20133 Istituto Clinico Humanitas Rozzano (MI), Italy, 20089 Azienda Sanitaria Ospedaliera San Giovanni Battista Molinette Turin, Italy, 10126 Collapse <<

• 更多
• 参考文献

• [1] Bendell JC, Kelley RK, et al. A phase I dose-escalation study to assess safety, tolerability, pharmacokinetics, and preliminary efficacy of the dual mTORC1/mTORC2 kinase inhibitor CC-223 in patients with advanced solid tumors or multiple myeloma. Cancer. 2015 Oct 1;121(19):3481-90.

  [2] Mortensen DS, Perrin-Ninkovic SM, et al. Discovery of mammalian target of rapamycin (mTOR) kinase inhibitor CC-223. J Med Chem. 2015 Jul 9;58(13):5323-33.