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CAS No.: 350997-39-6

OGG1-IN-08 Catalog No. CSN25635

Synonyms: O8 OGG1 Inhibitor-Bio-X;OGG1-IN-O8;OGG1 Inhibitor O8

O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35μM in fluorescence-based OGG1 assays. It can inhibit Schiff base formation during OGG1-mediated catalysis but did not reduce DNA binding of OGG1 to a 7,8-dihydro-8-oxoguanine (8-oxo-Gua)-containing substrate.

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描述The base excision repair (BER) pathway, which utilizes DNA glycosylases to initiate repair of specific DNA lesions, is the major pathway for the repair of oxidatively induced lesions in cellular DNA. 8-oxoguanine DNA glycosylase-1 (OGG1) is the human DNA glycosylase responsible for removal of the highly mutagenic 7,8-dihydro-8-oxoguanine (8-oxo-Gua) and 2,6-diamino-4-hydroxy-5-formamidopyrimidine (FapyGua) lesions from DNA. O8 OGG1 Inhibitor is an inhibitor of OGG1 with IC50 value of 0.35 μM in fluorescence-based OGG1 assays^[1]. Mechanism: OGG1 Inhibitor O8 inhibits OGG1 through the inhibition of Schiff base formation during OGG1 catalysis^[1].
参考文献

[1] Donley N, Jaruga P, Coskun E, Dizdaroglu M, McCullough AK, Lloyd RS. Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol. 2015;10(10):2334-2343.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.8295 mL
- 19.1477 mL
- 38.2954 mL
- 5 mM
- 0.7659 mL
- 3.8295 mL
- 7.6591 mL
- 10 mM
- 0.3830 mL
- 1.9148 mL
- 3.8295 mL

技术信息

CAS号	350997-39-6	储存条件	粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C9H6Cl2N2OS	运输	蓝冰
分子量	261.13	别名	O8 OGG1 Inhibitor-Bio-X;OGG1-IN-O8;OGG1 Inhibitor O8

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