CAS No.: 940310-85-0
NVP-BHG 712 Catalog No. CSN16663
Synonyms: BHG712
NVP-BHG712 is a specific EphB4 inhibitor with ED50 of 25 nM that discriminates between VEGFR and EphB4 inhibition and also shows activity against c-Raf, c-Src and c-Abl with IC50 of 0.395 μM, 1.266 μM and 1.667 μM, respectively.
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Kathawala RJ, Wei L, et al. The small molecule tyrosine kinase inhibitor NVP-BHG712 antagonizes ABCC10-mediated paclitaxel resistance: a preclinical and pharmacokinetic study. Oncotarget. 2015 Jan 1;6(1):510-21.
- [2] Martiny-Baron G, Holzer P, et al. The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis. Angiogenesis. 2010 Sep;13(3):259-67.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 940310-85-0 | 储存条件 |
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| 分子式 | C26H20F3N7O | 运输 | 蓝冰 | |||||||
| 分子量 | 503.48 | 别名 | BHG712 | |||||||
| 溶解度 |
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动物实验配方 |
