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CAS No.: 475488-23-4
Synonyms: ADW742;GSK 552602A;ADW
NVP-ADW742 is an selective IGF-1R inhibitor with IC50 of 0.17 μM, > 16-fold more potent against IGF-1R than InsR and shows little activity to HER2, PDGFR, VEGFR-2, Bcr-Abl and c-Kit.
生物活性
实验方案
技术信息
CAS号 | 475488-23-4 | 储存条件 |
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分子式 | C28H31N5O | 运输 | 蓝冰 | |
分子量 | 453.58 | 别名 | ADW742;GSK 552602A;ADW |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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MiaPaCa2 cells | - | Function assay | - | Inhibition IGF1R phosphorylation in human MiaPaCa2 cells, IC50=0.323 μM | 17689078 |
Sf21 cells | - | Function assay | - | Inhibition of human IGF1R expressed in Sf21 cells by time-resolved fluorescence assay, IC50=0.078 μM | 17689078 |
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