|3,5-双(4-甲基亚苄基)哌啶-4-酮盐酸盐|CsnPharm

CAS No.: 157654-67-6

NSC632839 Catalog No. CSN18918

Synonyms: F6;Ubiquitin Isopeptidase Inhibitor II

NSC 632839 HCl is an nonselective inhibitor of isopeptidase and inhibits various proteins including USP2, USP7, and SENP2 (EC50 = 45 ± 4 μM, 37 ± 1 μM, and 9.8 ± 1.8 μM, respectively).

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 USP7

EC50:37±1μM USP2

EC50:45±4μM SENP2

EC50:9.8±1.8μM
描述Deubiquitylases (DUBs), isopeptidases that cleave at the carboxyl terminus of ubiquitin, have been divided into five distinct groups, the largest being the ubiquitin-specific proteases (USP/UBP). NSC 632839 is an inhibitor of DUB with IC50 values of 45 nM, 37 nM and 9.8 nM for USP2, USP7, and SENP2, respectively^[3]. In vitro, treatment with 10 μM NSC 632839 activated caspase-3/caspase-7 and triggered apoptosis in IMR90-E1A and E1A/C9DN cells. NSC 632839 inhibited IMR90-E1A and E1A/C9DN cells proliferation with IC50 values of 15.65 μM and 16.23 μM^[4]. Treatment with 10 μM NSC 632839 strongly induced LC3 puncta formation in Hela cells^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9424 mL
- 14.7120 mL
- 29.4240 mL
- 5 mM
- 0.5885 mL
- 2.9424 mL
- 5.8848 mL
- 10 mM
- 0.2942 mL
- 1.4712 mL
- 2.9424 mL

技术信息

CAS号

157654-67-6

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C21H22ClNO

运输

蓝冰

分子量

339.86

别名

F6;Ubiquitin Isopeptidase Inhibitor II

溶解度

DMSO	7.0 mg/mL (20.6 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

靶点	Description	IC50
USP7		EC50:37±1μM
USP2		EC50:45±4μM
SENP2		EC50:9.8±1.8μM

NSC632839 Catalog No. CSN18918

靶点选择性

请登录您的专属账户

确认信息