|N6-(2-((5-(二乙氨基)戊烷-2-基)氨基)-6-甲基嘧啶-4-基)-2-甲基喹啉-4,6-二胺三盐酸盐|CsnPharm

CAS No.: 1177865-17-6

NSC 23766 3HCl Catalog No. CSN16515

Synonyms: NSC 23766 (hydrochloride);NSC23766 3HCl salt;NSC23766 hydrochloride

NSC23766 is identified to fit into a surface groove of Rac1 known to be critical for GEF specification.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 Rac

IC50:~50μM
细胞研究

Cell Data

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources
A172MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
A172MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
A431	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.8834 mL
- 9.4168 mL
- 18.8337 mL
- 5 mM
- 0.3767 mL
- 1.8834 mL
- 3.7667 mL
- 10 mM
- 0.1883 mL
- 0.9417 mL
- 1.8834 mL

技术信息

CAS号

1177865-17-6

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H38Cl3N7

运输

蓝冰

分子量

530.96

别名

NSC 23766 (hydrochloride);NSC23766 3HCl salt;NSC23766 hydrochloride

溶解度

DMSO	8.75 mg/mL (16.5 mM)
Water	29.0 mg/mL (54.6 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Cell Lines	Concentration	Assay Type	Time	Activity Description	Data Sources

A172MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
A172MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
A431	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
A431	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
IEC-6	120 µM	Function Assay	4/6/8 h	prevents the increased activation of FAK at 6 and 8 h	20448461
Ki-67+ CLL	50 µM	Growth Inhibition Assay	5 d	decreases the number of Ki-67+ CLL cells	24501217
MCF7	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MCF7	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
MDA-MB-231	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MDA-MB-231	0-100 μM	Function Assay	24 h	selectively inhibits Rac1 activation without interfering with the activity of the closely related small GTPase Cdc42	20515940
MDA-MB-231	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
MDA-MB-231	50/100 μM	Function Assay	24 h	increases phosphorylation of JNK in a dose dependent manner	20515940
MDA-MB-231	50/100 μM	Function Assay	48 h	induces a dose-dependent decrease in phosphorylation of p65 subunit	20515940
MDA-MB-468	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
MDA-MB-468	50/100 μM	Apoptosis Assay	24 h	induces apoptosis	20515940
MDA-MB-468	100 μM	Function Assay	24 h	inhibits caspase-3 activation	20515940
MDA-MB-468	50/100 μM	Function Assay	24 h	increases phosphorylation of JNK in a dose dependent manner	20515940
MDA-MB-468	50/100 μM	Function Assay	48 h	induces a dose-dependent decrease in phosphorylation of p65 subunit	20515940
NCI-H1703	0-500 μM	Growth Inhibition Assay	24 h	inhibits cell growth in a dose dependent manner	22549160
NCI-H1703	100 μg/ml	Function Assay	24 h	slows progression through the G1 phase of the cell cycle	22549160
NCI-H1703	0-500 μM	Function Assay	24 h	diminishes basal NF-κB activity dose dependently	22549160
NIH3T3	100 μM	Growth Inhibition Assay	24 h	has no significant impact on cell viability	25037060
PC38	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
PC40	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
RA1	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA2	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA3	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA4	50 μM	Function Assay	24 h	inhibits Matrigel invasion	17622308
RA-FLS (RA2)	25/50 μM	Growth Inhibition Assay	1-9 d	inhibits cell growth in both dose and time dependent manner	17622308
RBMECs	100 μM	Function Assay	30 min	blockes 6Bnz-cAMP-mediated activation of Rac1 in EMAP-II-treated RBMECs	26358039
SKBR3	50 μM	Function Assay	24 h	inhibits Rac1 activation	21943825
SKBR3-pMKO.1	50 μM	Function Assay	24 h	inhibits Rac1 activation	21943825
SW480	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
SW480	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
T47D	0-100 μM	Cytotoxicity Assay	48 h	decreases cell viability in a dose dependent manner	20515940
T47D	100 μM	Function Assay	48 h	increases the cell number in G1 phase and decreases the cell number in S and G2-M phases	20515940
T98MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
T98MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120
U2-OS	100 μM	Growth Inhibition Assay	24/48/72 h	inhibits cell growth in a time dependent manner	25109327
U2-OS	100 μM	Function Assay	24 h	induces cell cycle arrest in the G1 phase	25109327
U87MG	50 mM	Cell Viability Assay	144 h	exhibits synergistic antiproliferative effects combined treatment with erlotinib	23832120
U87MG	50 mM	Function Assay	24 h	enhances the antimigratory effect of erlotinib	23832120

NSC 23766 3HCl Catalog No. CSN16515

靶点选择性

请登录您的专属账户

确认信息