|2-(3-(3-(三氟甲基)苯基)脲基)苯甲酸|CsnPharm

CAS No.: 1566-81-0

NS1652 Catalog No. CSN22216

Synonyms: Ns1652

NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述NS1652 is a reversible anion conductance inhibitor, blocks chloride channel, with an IC50 of 1.6 μM in human and mouse red blood cells. NS1652 markedly blocks the NO production with an IC50 of 3.1 μM in BV2 cells. NS1652 also down-regulates iNOS expression at 3 μM, and completely abolishes at 10 μM in BV2 cells^[1]. NS1652 (0, 1.0, 3.3, 10, and 20 μM) causes increasing hyperpolarization due to inhibition of the chloride conductance in normal erythrocytes. NS1652 lowers the net KCl loss from deoxygenated sickle cells from about 12 mM cells/h to about 4 mM cells/h. NS1652 (20 μM) completely and reversiblely inhibits the red cell Cl-conductance. NS1652 (50 mg/kg, i.v.) blocks murine erythrocyte Cl- conductance by >90% in mice^[2].
参考文献

[1] Kjaer K, Strøbaek D, Christophersen P, Rønn LC. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. 2009 Jul 24;1281:15-24
[2] Bennekou P, Pedersen O, Møller A, Christophersen P. Volume control in sickle cells is facilitated by the novel anion conductance inhibitor NS1652. Blood. 2000 Mar 1;95(5):1842-8

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0840 mL
- 15.4200 mL
- 30.8400 mL
- 5 mM
- 0.6168 mL
- 3.0840 mL
- 6.1680 mL
- 10 mM
- 0.3084 mL
- 1.5420 mL
- 3.0840 mL

技术信息

CAS号

1566-81-0

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C15H11F3N2O3

运输

蓝冰

分子量

324.25

别名

Ns1652

溶解度

DMSO	5.0 mg/mL (15.4 mM) warming

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NS1652 Catalog No. CSN22216

靶点选择性

请登录您的专属账户

确认信息