|三七皂苷R1|CsnPharm

CAS No.: 80418-24-2

Notoginsenoside R1/三七总皂苷 Catalog No. CSN12776

Synonyms: Sanchinoside R1;Sanqi glucoside R1;三七皂苷 R1

Notoginsenoside R1, the main bioactive component isolated and purified from the roots of Panax notoginseng (Burk.)F.H.Chen, is reported to have some neuronal protective, antihypertensive effects.

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技术信息

生物活性

描述Notoginsenoside R1 (NR1), the main bioactive component in panaxnotoginseng, is reported to have some neuronal protective, antihypertensive effects. NR1 significantly reduce blood pressure in SHR (spontaneously hypertensive rats) and induce nitric oxide (NO) generation through increasing the phosphorylation of iNOS (inducible nitric oxide synthase) ^[3]. R1 is a novel cardioprotective agent that can attenuate adverse cardiac dysfunction, hypertrophy, and associated disorders, such as fibrosis. R1-supressed cardiac dysfunction, atherosclerotic lesions, and inflammatory cytokine accumulation in the myocardium can be partially inhibited by CCR2 (CC chemokine receptor 2) translation in bone marrow cells^[4]. In addition, retinal vascular degeneration, reduced retinal thickness, and impaired retinal function in db/db mice were all dramatically attenuated by oral treatment with NGR1 (30 mg/kg) for 12 weeks. NGR1 pretreatment also significantly inhibited apoptosis, markedly suppressed the VEGF expression, markedly increased PEDF expression and markedly inhibited oxidative stress and inflammation in rat retinal Müller cells (rMC-1) subjected to high glucose (HG) and in the retinas of db/db mice^[5].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02975076	Stroke, Acute ... more >> Ischemic Attack, Transient Collapse <<	Not Applicable	Not yet recruiting	November 2019	-
NCT02316730	Healthy	Phase 1	Completed	-	China, Sichuan ... more >> West China Second University Hospital Chengdu, Sichuan, China, 610000 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.0717 mL
- 5.3583 mL
- 10.7167 mL
- 5 mM
- 0.2143 mL
- 1.0717 mL
- 2.1433 mL
- 10 mM
- 0.1072 mL
- 0.5358 mL
- 1.0717 mL

技术信息

CAS号

80418-24-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C47H80O18

运输

蓝冰

分子量

933.13

别名

Sanchinoside R1;Sanqi glucoside R1;三七皂苷 R1

溶解度

DMSO	100.0 mg/mL (107.2 mM)

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