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CAS No.: 1262417-51-5
NMS-P118 is a potent, orally available, and highly selective PARP-1 inhibitor for cancer therapy with an IC50 of 0.04 μM in HeLa cell.
生物活性
实验方案
技术信息
CAS号 | 1262417-51-5 | 储存条件 |
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分子式 | C20H24F3N3O2 | 运输 | 蓝冰 | |
分子量 | 395.42 | 别名 |
Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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HeLa cells | - | Function assay | 30 mins | Inhibition of PARP1 in human HeLa cells assessed as reduction of H2O2-induced PAR formation preincubated for 30 mins followed by H2O2 addition measured after 15 mins by immunocytochemical analysis, IC50=0.04 μM | 26222319 |
MDA-MB-436 cells | - | Cytotoxicity assay | 10 to 14 days | Cytotoxicity against BRCA1-deficient human MDA-MB-436 cells assessed as inhibition of colony formation after 10 to 14 days by crystal violet staining, IC50=0.14 μM | 26222319 |
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