|N-(2-(((2-((二甲基氨基)甲基)噻唑-4-基)甲基)硫基)乙基)-N-甲基-2-硝基乙烯-1,1-二胺|CsnPharm

CAS No.: 76963-41-2

Nizatidine/尼扎替丁 Catalog No. CSN11565

Synonyms: LY139037;Tazac;Axid

Nizatidine is an antagonist of histamine H2 receptor that can inhibit the secretion of gastric acid.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Nizatidine is a histamine type 2 receptor antagonist (H2 blocker) which is widely used for treatment of acid-peptic disease and heartburn. Nizatidine has been linked to rare instances of clinically apparent acute liver injury^[3]. In rat and dog models, species in which the absorption, plasma half-life and routes of metabolism are similar to that of humans, nizatidine was three- to four-fold more active than cimetidine and was of similar potency to ranitidine. Nizatidine was well-tolerated in animals after both intravenous and oral administration and following single or repeated administration^[4]. Nizatidine administration significantly improved both gastric emptying and clinical symptoms in FD (functional dyspepsia) patients with impaired gastric emptying^[5]. Intravenous administration of nizatidine (0.3 - 3 mg/kg) enhanced the motility of the gastric antrum and duodenum during the digestive state. Gastric emptying of a solid test meal was accelerated by intraperitoneal administration of nizatidine (1 - 10 mg/kg) to the same extent as cisapride (0.1 - 1 mg/kg). Furthermore, nizatidine improved clonidine-induced delayed gastric emptying^[6].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03509831	Gastritis	Phase 1	Active, not recruiting	April 2018	Korea, Republic of ... more >> Kukje Pharm Seongnam-si, Korea, Republic of Collapse <<
NCT02555852	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT02703896	Pulmonary Aspiration of Gastri... more >>c Contents Collapse <<	Phase 4	Completed	-	-

更多
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.0170 mL
- 15.0849 mL
- 30.1698 mL
- 5 mM
- 0.6034 mL
- 3.0170 mL
- 6.0340 mL
- 10 mM
- 0.3017 mL
- 1.5085 mL
- 3.0170 mL

技术信息

CAS号

76963-41-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C12H21N5O2S2

运输

蓝冰

分子量

331.46

别名

LY139037;Tazac;Axid;尼扎替丁

溶解度

DMSO	66.0 mg/mL (199.1 mM)
Ethanol	18.0 mg/mL (54.3 mM)

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

NCT03509831	Gastritis	Phase 1	Active, not recruiting	April 2018	Korea, Republic of ... more >> Kukje Pharm Seongnam-si, Korea, Republic of Collapse <<
NCT02555852	-	-	Completed	-	Canada, Quebec ... more >> Lady Davis Institute for Medical Research, Jewish General Hospital Montreal, Quebec, Canada, H3T1E2 Collapse <<
NCT02703896	Pulmonary Aspiration of Gastri... more >>c Contents Collapse <<	Phase 4	Completed	-	-
NCT02951715	Hearing Loss, Noise-Induced ... more >> Tinnitus, Noise Induced Zinc Deficiency Collapse <<	Not Applicable	Completed	-	-
NCT00486005	Schizophrenia	Phase 4	Completed	-	Brazil ... more >> For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician Rio de Janeiro, Brazil Collapse <<
NCT00373334	Gastroesophageal Reflux Diseas... more >>e GERD Heartburn Collapse <<	Phase 3	Completed	-	-
NCT01161927	Healthy	Phase 1	Completed	-	-
NCT02232308	Gastroparesis	Phase 1	Completed	-	United States, Minnesota ... more >> Mayo Clinic in Rochester Rochester, Minnesota, United States, 55905 Mayo Clinic Rochester, Minnesota, United States, 55905 Collapse <<
NCT01161940	Healthy	Phase 1	Completed	-	-
NCT00373334	-	-	Completed	-	-
NCT01409395	Healthy	Phase 1	Completed	-	United States, California ... more >> Ucsf Ctsi Crc San Francisco, California, United States, 94158 Collapse <<

Nizatidine/尼扎替丁 Catalog No. CSN11565

靶点选择性

请登录您的专属账户

确认信息