|4-((N-苄基-8-氯-1-甲基-1,4-二氢本并吡喃并[4,3-c]吡唑-3-甲酰胺基)甲基)苯甲酸|CsnPharm

CAS No.: 1773489-72-7

Nidufexor Catalog No. CSN21073

Synonyms: LMB763

Nidufexor is a potent farnesoid X receptor (FXR) agonist for the treatment of non-alcoholic steatohepatitis (NASH) and hepatobiliary disorders.

规格	价格	促销价格	库存	数量

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

加入购物车大规格询价

加入收藏

产品咨询

400-920-2911

sales@csnpharm.cn

tech@csnpharm.cn

纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

描述The farnesoid X receptor (FXR) is a bile acid (BA)-activated nuclear receptor highly expressed in the liver, gall bladder, intestines, and kidney that regulates BA production, conjugation, and transport. Nidufexor is a novel FXR agonist for the treatment of nonalcoholic steatohepatitis (NASH). In adult male Wistar Han rats (age approximately 10 weeks), nidufexor exhibited moderate C_max (4.5, 12.4, 28.1, 80.9, and 140.8 μM) and terminal elimination half-lives (t_1/2; 3.9, 5.7, 6.3, 5.6, 6.3 h) following oral administration (3, 10, 30, 100, and 300 mg/kg). Following intravenous administration (mouse 3.0, rat 5.0 and, dog 0.5 mg/kg), nidufexor exhibited t_1/2 values of 4.5, 4.4 and 6.8 h for mouse, rat and dog, respectively. While following oral administration (mouse 10, rat 10 and, dog 2 mg/kg), nidufexor exhibited t_1/2 values of 3.5, 2.7 and 10.1 h for mouse, rat and dog, respectively. Nidufexor has advanced to Phase 2 human clinical trials in patients with NASH and diabetic nephropathy^[1].
参考文献

[1] Chianelli D, Rucker PV, Roland J, et al. Nidufexor (LMB763), a Novel FXR Modulator for the Treatment of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Apr 23;63(8):3868-3880

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.0495 mL
- 10.2473 mL
- 20.4946 mL
- 5 mM
- 0.4099 mL
- 2.0495 mL
- 4.0989 mL
- 10 mM
- 0.2049 mL
- 1.0247 mL
- 2.0495 mL

技术信息

CAS号

1773489-72-7

储存条件

粉末: Sealed in dry,Store in freezer, under -20°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H22ClN3O4

运输

蓝冰

分子量

487.93

别名

LMB763

溶解度

DMSO	99.0 mg/mL (202.9 mM)
Water	Insoluble
Ethanol	Insoluble

动物实验配方

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

Nidufexor Catalog No. CSN21073

靶点选择性

请登录您的专属账户

确认信息