|(S)-7-(1,4-二甲基-1H-1,2,3-三唑-5-基)-1-甲基-9-(苯基(四氢-2H-吡喃-4-基)甲基)-1,9-二氢吡啶并[2',3':4,5]吡咯并[3,2-f]吲唑|CsnPharm

CAS No.: 2115742-03-3

Synonyms: NHWD-870

NHWD-870 is a potent and selective BET inhibitor that targets the bromodomains of BRD2/3/4 with IC50 values of 2.7nM, as well as BRDT.

规格	价格	促销价格	库存	数量

400-920-2911

加入购物车大规格询价

产品咨询

400-920-2911

纯度 & 质量文件批次:

生物活性

描述NHWD-870 is a potent and selective BET inhibitor that targets the bromodomains of BRD2/3/4 with IC50 values of 2.7nM, as well as BRDT. It has multiple anti-tumor effects, including the inhibition of tumor cell proliferation, c-MYC expression, and BRD4 phosphorylation, as well as the induction of apoptosis. It also blocks the proliferation of tumor associated macrophages (TAMs) by suppressing the expression and secretion of CSF1 from tumor cells. The inhibition of CSF1 is mediated by the downregulation of BRD4 and its target HIF1α. NHWD-870 shows potent activity against A375 cells with an IC50 value of 2.46nM. It also exhibits oral bioavailability and strong anti-tumor efficacy in mouse models bearing various tumor types, such as NCI-H526, A2780, A375, B16F10, and TMD-8 cells, at doses of 0.75-3 mg/kg^[1].
参考文献

实验方案

技术信息

CAS号	2115742-03-3	储存条件	粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6 月 -80°C:12月
分子式	C29H29N7O	运输	蓝冰
分子量	491.59	别名	NHWD-870

大规格询价

号为必填项

姓名: 邮箱: 手机号:

留言:

提交

请登录您的专属账户