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CAS No.: 130773-02-3

Neticonazole HCl/盐酸奈替康唑 Catalog No. CSN22603

Synonyms: Neticonazole HCL;SS-717

Neticonazole HCl is an imidazole antifungal for the treatment of fungal skin infections.

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实验方案

技术信息

生物活性

描述Colorectal cancer (CRC) is the most frequently encountered malignancy associated with the rectum or colon, and accumulating evidences have implicated intestinal dysbacteriosis (IDB, disruption of gut microbiome) and exosomes in the pathology of CRC^[1]. Neticonazole hydrochloride is a imidazole derivative and a potent and long-acting antifungal agent^[2]. Neticonazole is also a novel exosome secretion inhibitor. In IDB mice bearing CRC xenograft tumors, IDB promoted CRC xenograft tumor growth and exosome secretion, which could be inhibited by the exosome secretion inhibitor neticonazole. Moreover, neticonazole treatment significantly improved the survival of IDB mice with CRC xenograft tumors, likely through increasing apoptosis of CRC xenograft tumor cells^[1]. In animals treated with 1% neticonazole cream, a significant mycological improvement was observed when compared to untreated controls. The mycological result of the neticonazole solution treated group was significantly superior to those of the untreated control group, the solution vehicle-treated group and the BFZ (bifonazole) solution-treated group^[3].
参考文献

[1] Gu L, Xu Y, Xu W, et al. The exosome secretion inhibitor neticonazole suppresses intestinal dysbacteriosis-induced tumorigenesis of colorectal cancer. Invest New Drugs. 2020;38(2):221-228.
[2] Tsuboi R, Matsumoto T, Ogawa H. Hyperkeratotic chronic tinea pedis treated with neticonazole cream. Neticonazole Study Group. Int J Dermatol. 1996;35(5):371-373.
[3] Maebashi K, Itoyama T, Uchida K, Yamaguchi H, Asaoka T, Iwasa A. Jpn J Antibiot. 1993;46(10):896-903.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.9508 mL
- 14.7538 mL
- 29.5076 mL
- 5 mM
- 0.5902 mL
- 2.9508 mL
- 5.9015 mL
- 10 mM
- 0.2951 mL
- 1.4754 mL
- 2.9508 mL

技术信息

CAS号

130773-02-3

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C17H23ClN2OS

运输

蓝冰

分子量

338.90

别名

Neticonazole HCL;SS-717

溶解度

DMSO	215.0 mg/mL (634.4 mM) warming
Water	240.0 mg/mL (708.2 mM)

动物实验配方

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Neticonazole HCl/盐酸奈替康唑 Catalog No. CSN22603

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