CAS No.: 51551-29-2
Neoechinulin A Catalog No. CSN14542
Neoechinulin A, a natural product isolated and purified from Aspergillus chevalieri with anti-inflammatory effect against LPS-stimulated RAW264.7 macrophages through inhibition of the NF-κB and p38 MAPK pathways, may block the phosphorylation of mitogen-activated protein kinase (MAPK) molecule p38, apoptosis signal-regulating kinase 1 (ASK-1) and nuclear translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits, and ameliorate rotenone toxicity by activating a cytoprotective machinery that requires ATP and antioxidant/anti-nitration activities.
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400-920-2911
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纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Kim KS, Cui X, et al. Anti-inflammatory effect of neoechinulin a from the marine fungus Eurotium sp. SF-5989 through the suppression of NF-кB and p38 MAPK Pathways in lipopolysaccharide-stimulated RAW264.7 macrophages. Molecules. 2013 Oct 25;18(11):13245-59.
- [2] Dewapriya P, Li YX, et al. Neoechinulin A suppresses amyloid-β oligomer-induced microglia activation and thereby protects PC-12 cells from inflammation-mediated toxicity. Neurotoxicology. 2013 Mar;35:30-40.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 51551-29-2 | 储存条件 |
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| 分子式 | C19H21N3O2 | 运输 | 蓝冰 | |
| 分子量 | 323.39 | 别名 |
