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CAS No.: 41060-15-5

Neobavaisoflavone/新补骨脂异黄酮 Catalog No. CSN13946

Synonyms: 新补骨脂异黄酮

Neobavaisoflavone, an isoflavone isolated from the seeds of Psoralea corylifolia, has striking anti-inflammatory and anti-cancer effects.

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400-920-2911

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技术信息

生物活性

描述Neobavaisoflavone (NBIF), a flavonoid, is isolated from the seeds of Psoralea corylifolia. Neobavaisoflavone exhibits anti-inflammatory, anti-cancer and anti-oxidation activities. Neobavaisoflavone significantly inhibited the production of reactive oxygen species (ROS), reactive nitrogen species (RNS) and cytokines: IL-1β, IL-6, IL-12p40, IL-12p70, TNF-α in LPS+IFN-γ- or PMA- stimulated RAW264.7 macrophages^[2]. NBIF is a natural inducer of UGT1A1(UDP-glucuronosyltransferase 1A1), while this agent induced UGT1A1 mainly via activating and up-regulating PPARα and PPARγ^[3]. NBIF inhibited RANKL-mediated osteoclastogenesis by suppressing the recruitment of TRAF6 and c-Src to RANK, inactivating NF-κB, MAPKs, and Akt signalling pathways and inhibiting calcium oscillation and NFATc1 (nuclear factor of activated T cells cytoplasmic 1) translocation^[4]. NBI (neobavaisoflavone) inhibited melanin production through the regulation of MEK/ERK and Akt/GSK-3β signaling pathways in α-MSH-stimulated B16F10 cells. NBI suppresses tyrosinase activity and melanogenesis through inhibition of α-glucosidase activity. Besides, NBI significantly reduced melanogenesis in a reconstructed human 3D skin model^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.1022 mL
- 15.5109 mL
- 31.0217 mL
- 5 mM
- 0.6204 mL
- 3.1022 mL
- 6.2043 mL
- 10 mM
- 0.3102 mL
- 1.5511 mL
- 3.1022 mL

技术信息

CAS号

41060-15-5

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C20H18O4

运输

蓝冰

分子量

322.35

别名

新补骨脂异黄酮

溶解度

DMSO	30.0 mg/mL (93.1 mM)

动物实验配方

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Neobavaisoflavone/新补骨脂异黄酮 Catalog No. CSN13946

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