生物活性

• 描述Nemonoxacin malate is a non-fluorinated quinolone antibiotic approved for treatment of community-acquired pneumonia, and exhibits potent activity against Gram-positive bacteria, including MRSA and fluoroquinolone-resistant MRSA, Gram-negative and atypical pathogens.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT03362853	Healthy Volunteers	Phase 1	Completed	-	-
  NCT01537250	Community-acquired Pneumonia	Phase 2	Completed	-	China ... more >> Beijing Chaoyang Hospital, Capital Medical University Beijing, China Beijing Union Medical College Hospital, Chinese Academy of Medical Sciences Beijing, China Peking University First Hospital Beijing, China Peking University People's Hospital Beijing, China PLA Second Artillery General Hospital Beijing, China Zhen Hospital, Capital Medical University Beijing Beijing, China Daping Hospital, Third Military Medical University Chongqing, China First Affiliated Hospital of Fujian Medical University Fujian, China Gansu Provincial People's Hospital Gansu, China Guangzhou Red Cross Hospital Guangzhou, China Second Affiliated Hospital of Sun Yat-sen Guangzhou, China Affiliated Hospital of Guilin Medical College Guilin, China Taihe Hospital in Shiyan City, Hubei Province Hubei, China Third Xiangya Hospital, Central South University Hunan, China Jiangxi Provincial People's Hospital Jiangxi, China Second Affiliated Hospital of Nanchang University Jiangxi, China Jinan Central Hospital Jinan, China Shengjing Hospital of China Medical University Liaoning, China Nanjing General Hospital of Nanjing Military Region Nanjing, China Institute of Antibiotics,Huashan Hospital ,Fudan University Shanghai,, China Huashan Hospital ,Fudan University Shanghai, China Institute of Antibiotics, Huashan Hospital, Fundan University Shanghai, China Shanghai Pudong New Area, Oriental Hospital Shanghai, China Shanghai Putuo District Central Hospital Shanghai, China First Hospital of Shanxi Medical University Shanxi, China People's Liberation Army General Hospital of Shenyang Military Region Shenyang, China Shenzhen People's Hospital ShenZhen, China West China Hospital of Sichuan University (Respiratory) Sichuan, China Second Affiliated Hospital of Wenzhou Medical College Wenzhou, China People's Hospital of Wuhan University Wuhan, China Wuhan General Hospital of PLA Guangzhou Military Region Wuhan, China First Affiliated Hospital, Zhejiang University School of Medicine Zhejiang, China Collapse <<
  NCT01944774	Pneumonia	Phase 2	Completed	-	China ... more >> Institute of Antibiotics, Huashan Hospital, Fundan University Shanghai, China, 200040 Taiwan Far eastern memorial hospital Taipei, Taiwan Collapse <<

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• 参考文献

• [1] He G, Guo B, et al. Determination of a novel nonfluorinated quinolone, nemonoxacin, in human feces and its glucuronide conjugate in human urine and feces by high-performance liquid chromatography-triple quadrupole mass spectrometry. Biomed Chromatogr. 2015 May;29(5):739-48.

  [2] Lauderdale TL, Shiau YR, et al. Comparative in vitro activities of nemonoxacin (TG-873870), a novel nonfluorinated quinolone, and other quinolones against clinical isolates. Antimicrob Agents Chemother. 2010 Mar;54(3):1338-42.