生物活性

• 描述ABT-126 is an alpha7 nicotinic acetylcholine receptor agonist and nicotinic acetylcholine receptor agonist. Nelonicline is potentially useful for the treatment of Alzheimer's diseases. ABT-126 may be useful to reduce dyskinesias in both early- and later-stage Parkinson's disease.
• 临床研究

• NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
  NCT00948909	Alzheimer's Disease	Phase 2	Completed	-	United States, California ... more >> Site Reference ID/Investigator# 19904 Fresno, California, United States, 93720 United States, Florida Site Reference ID/Investigator# 23025 West Palm Beach, Florida, United States, 33407 United States, Indiana Site Reference ID/Investigator# 19905 Indianapolis, Indiana, United States, 46260 Bulgaria Site Reference ID/Investigator# 22944 Pleven, Bulgaria, 5800 Site Reference ID/Investigator# 22942 Plovdiv, Bulgaria, 4000 Site Reference ID/Investigator# 22945 Sofia, Bulgaria, 1113 Site Reference ID/Investigator# 22946 Sofia, Bulgaria, 1431 Czech Republic Site Reference ID/Investigator# 20276 Litomerice, Czech Republic, 412 01 Site Reference ID/Investigator# 20273 Plzen, Czech Republic, 301 36 Site Reference ID/Investigator# 20274 Prague 10, Czech Republic, 100 00 Site Reference ID/Investigator# 20272 Prague 2, Czech Republic, 120 00 Site Reference ID/Investigator# 20701 Prague 5, Czech Republic, 15006 Slovakia Site Reference ID/Investigator# 23625 Bratislava, Slovakia, 82606 Site Reference ID/Investigator# 23624 Bratislava, Slovakia Site Reference ID/Investigator# 23622 Michalovce, Slovakia, 07101 Site Reference ID/Investigator# 23942 Rimavska Sobota, Slovakia, 979 12 South Africa Site Reference ID/Investigator# 20267 Belville, South Africa, 7530 Site Reference ID/Investigator# 20266 Cape Town, South Africa, 7500 Site Reference ID/Investigator# 20261 Durban, South Africa, 4001 Site Reference ID/Investigator# 21682 George, South Africa, 6529 Site Reference ID/Investigator# 20265 Johannesburg, South Africa, 2196 Site Reference ID/Investigator# 20271 Port Elizabeth, South Africa, 6001 Site Reference ID/Investigator# 20263 Richards Bay, South Africa, 3900 United Kingdom Site Reference ID/Investigator# 20187 Blackburn, United Kingdom, BB2 3HH Site Reference ID/Investigator# 20183 Bradford, United Kingdom, BD3 0DQ Site Reference ID/Investigator# 20191 Crowborough, United Kingdom, TN6 1HB Site Reference ID/Investigator# 20184 Glasgow, United Kingdom, G20 0XA Site Reference ID/Investigator# 20190 London, United Kingdom, TW8 8DS Site Reference ID/Investigator# 20192 Southampton, United Kingdom, SO30 3JB Collapse <<
  NCT01095562	Cognitive Deficits in Schizoph... more >>renia Collapse <<	Phase 2	Completed	-	United States, California ... more >> Site Reference ID/Investigator# 26267 Cerritos, California, United States, 90703 Site Reference ID/Investigator# 45320 Costa Mesa, California, United States, 92626 Site Reference ID/Investigator# 27068 Escondido, California, United States, 92025 Site Reference ID/Investigator# 52568 Garden Grove, California, United States, 92845 Site Reference ID/Investigator# 26266 Granada Hills, California, United States, 91344 Site Reference ID/Investigator# 26388 Oceanside, California, United States, 92056 Site Reference ID/Investigator# 45315 San Bernardino, California, United States, 92408 Site Reference ID/Investigator# 26271 San Diego, California, United States, 92102 Site Reference ID/Investigator# 27045 Santa Ana, California, United States, 92701 Site Reference ID/Investigator# 45314 Santa Ana, California, United States, 92705 Site Reference ID/Investigator# 26264 Torrance, California, United States, 90502 United States, Florida Site Reference ID/Investigator# 27072 Tampa, Florida, United States, 33613 United States, Kansas Site Reference ID/Investigator# 27043 Wichita, Kansas, United States, 67214 United States, Louisiana Site Reference ID/Investigator# 26395 Lake Charles, Louisiana, United States, 70629 United States, Missouri Site Reference ID/Investigator# 26268 Saint Louis, Missouri, United States, 63118 United States, New York Site Reference ID/Investigator# 26392 Fresh Meadows, New York, United States, 11366 Site Reference ID/Investigator# 27073 New York, New York, United States, 10065 Site Reference ID/Investigator# 26262 Rochester, New York, United States, 14618 United States, Ohio Site Reference ID/Investigator# 27071 Beachwood, Ohio, United States, 44122 United States, Pennsylvania Site Reference ID/Investigator# 36020 Media, Pennsylvania, United States, 19063 Site Reference ID/Investigator# 28063 Norristown, Pennsylvania, United States, 19401 Site Reference ID/Investigator# 27070 Sellersville, Pennsylvania, United States, 18960 United States, Texas Site Reference ID/Investigator# 27069 Dallas, Texas, United States, 75243 Collapse <<
  NCT00959634	Healthy Volunteers	Phase 1	Completed	-	United States, Texas ... more >> Site Reference ID/Investigator# 22863 Austin, Texas, United States, 78744 Collapse <<

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• 参考文献

• [1] Gault LM, Lenz RA, et al. ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension. Alzheimers Res Ther. 2016 Oct 18;8(1):44.

  [2] Hudzik TJ, Basso AM, et al. Preclinical abuse liability assessment of ABT-126, an agonist at the α7 nicotinic acetylcholine receptor (nAChR). Pharmacol Biochem Behav. 2017 Jun 1;158:22-31.