CAS No.: 1508250-72-3
Nazartinib mesylate/EGF816 甲磺酸盐 Catalog No. CSN17903
Synonyms: EGF816 mesylate;Nazartinib Mesylate
EGF816 mesylate is a covalent mutant-selective EGFR inhibitor, with Ki and Kinact of 31 nM and 0.222 min−1 on EGFR(L858R/790M) mutant, respectively.
| 规格 | 价格 | 促销价格 | 库存 | 数量 |
|---|
400-920-2911
sales@csnpharm.cn
tech@csnpharm.cn
纯度 & 质量文件
批次:
靶点选择性
生物活性
- 描述
- 参考文献
- [1] Lelais G, Epple R, et al. Discovery of (R,E)-N-(7-Chloro-1-(1-[4-(dimethylamino)but-2-enoyl] azepan-3-yl)-1H-benzo[d] imidazol-2-yl)-2-methylisonicotinamide (EGF816), a Novel, Potent, and WT Sparing Covalent Inhibitor of Oncogenic (L858R, ex19del) and Resistant (T790M) EGFR Mutants for the Treatment of EGFR Mutant Non-Small-Cell Lung Cancers. J Med Chem. 2016 Jul 28;59(14):6671-89.
- [2] Jia Y, Juarez J, et al. EGF816 Exerts Anticancer Effects in Non-Small Cell Lung Cancer by Irreversibly and Selectively Targeting Primary and Acquired Activating Mutations in the EGF Receptor. Cancer Res. 2016 Mar 15;76(6):1591-602.
实验方案
- 计算器
- 储存液制备
技术信息
| CAS号 | 1508250-72-3 | 储存条件 |
|
|
| 分子式 | C27H35ClN6O5S | 运输 | 蓝冰 | |
| 分子量 | 591.12 | 别名 | EGF816 mesylate;Nazartinib Mesylate |
