|(S)-5-羟基-2-(4-羟基苯基)-7-(((2S,3R,4S,5S,6R)-3,4,5-三羟基-6-((((2R,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)甲基)四氢-2H-吡喃-2-基)氧基)苯并吡喃4-酮|CsnPharm

CAS No.: 14259-46-2

Narirutin/芸香柚皮苷 Catalog No. CSN16161

Synonyms: Naringenin-7-O-rutinoside;(2S)-Narirutin;Isonaringenin

Narirutin is a flavanone-7-O-glycoside with antiproliferative, anti-depressant and anti-inflammatory properties. It can be isolated from the young fruit of Citrus grandis (L.) Osbeck.

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技术信息

生物活性

描述Narirutin is a flavanone-7-O-glycoside with antiproliferative, anti-depressant and anti-inflammatory properties. It can be isolated from the young fruit of Citrus grandis (L.) Osbeck. It is considered to be non-toxic with predicted high LD50 value, 12000 mg/kg body weight. The phytochemical is tested for its antitubercular activity in vitro. It has MIC99 62.5 μg/mL against the MtbH37Rv strain^[3]. At 10 mg/kg, but not 0.1 or 1 mg/kg, narirutin significantly diminished OVA-induced airway inflammation caused by infiltration of lung tissue with inflammatory and mucus-producing cells, as well as reduced eosinophil counts in the peripheral blood and bronchoalveolar lavage fluid (BALF), interleukin (IL)-4 levels in BALF and IgE levels in serum^[4]. The inhibitory mechanism of narirutin on RBL-2H3 cells degranulation could be related to regulate MAPK, NF-κB and Tyrosine kinase signaling pathway^[5]. NR (Narirutin) treatment for 1 week significantly alleviated the depressive-like behaviours of CMS-exposed mice, as indicated by restored decreased sucrose preference and shortened floating time in the forced swimming test. Moreover, NR treatment significantly blocked the CMS-induced anxiety-like behaviors, including increased time spent in the central zone in the open field test, and shortened the latency to feeding in the novelty suppressed feeding test^[6]. Narirutin has vasorelaxing effect and the mechanism involves the inhibition of phosphodiesterase, which increases intracellular cAMP, thereby stimulating the endothelial nitric oxide synthase and activating the voltage-gated potassium channels in vascular smooth muscle cells^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02380144	Healthy	Not Applicable	Unknown	July 2017	Germany ... more >> Chair of Plant Foodstuff Technology and Analysis (150d), University of Hohenheim Stuttgart, Baden-Württemberg, Germany, 70599 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7226 mL
- 8.6128 mL
- 17.2255 mL
- 5 mM
- 0.3445 mL
- 1.7226 mL
- 3.4451 mL
- 10 mM
- 0.1723 mL
- 0.8613 mL
- 1.7226 mL

技术信息

CAS号

14259-46-2

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H32O14

运输

蓝冰

分子量

580.53

别名

Naringenin-7-O-rutinoside;(2S)-Narirutin;Isonaringenin;Isonaringin;Naringenin 7-beta-rutinoside;芸香柚皮苷

溶解度

DMSO	100.0 mg/mL (172.3 mM)

动物实验配方

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