|1-(4-((2S,3R,4S,5S,6R)-4,5-二羟基-6-(羟甲基)-3-(((2S,3R,4R,5R,6S)-3,4,5-三羟基-6-甲基四氢-2H-吡喃-2-基)氧基)四氢-2H-吡喃-2-基)氧基)-2,6-二羟基苯基)-3-(4-羟基苯基)丙-1-酮|CsnPharm

CAS No.: 18916-17-1

Naringin dihydrochalcone/柚皮苷二氢查尔酮 Catalog No. CSN16184

Synonyms: Naringin DC;Naringin dihydrochalcone;柚皮苷二氢查尔酮

Naringin dihydrochalcone is a sweetening agent and an artificial sweetener derived from naringin and also an inhibitor of CYP enzymes.

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技术信息

生物活性

描述Naringin Dihydrochalcone is the dihydrochalcone form of Naringin. Naringin is a major flavanone glycoside obtained from tomatoes, grapefruits, and many other citrus fruits. It exhibits biological properties such as antioxidant, anti-inflammatory, and antiapoptotic activities. Naringenin, the aglycone formed by intestinal bacteria hydrolysis of naringin, competitively inhibits benzo(a)pyrene hydroxylase (AHH) activity with an estimated Ki of 39 microM. Naringin relieved kidney injury, improved renal function and inhibited collagen formation and renal interstitial fibrosis. It also restrained oxidative stress by activating Nrf2 antioxidant pathway. Moreover, the results suggested that naringin significantly resisted inflammatory reaction by inhibiting NF-κB signaling pathway. Taken together, those results demonstrate that naringin effectively alleviates diabetic kidney disease (DKD), which provide theoretical basis for naringin clinically used to treatment of DKD. AGS cell proliferation was inhibited by Naringin in a dose- and time-dependent manner. Phosphorylation of PI3K and its activated downstream targets p-Akt and p-mTOR are significantly decreased at 2 mM in Naringin-treated AGS cells. Naringin protects pheochromocytoma cells (PC12 cells) from 3-NP neurotoxicity, as evaluated by cell viability assays. The lactate dehydrogenase release was decreased upon naringin treatment in 3-NP-induced PC12 cells. Naringin treatment enhances the antioxidant defense by increasing the activities of enzymatic antioxidants and the level of reduced glutathione. Treatment with naringin significantly alleviates renal injury in diabetic rats and increases diabetic rats body weight significantly. Administration of naringin effectively alleviates the collagen deposition and renal interstitial fibrosis in diabetic rats. Treatment with naringin could result in decreased levels of ROS and MDA and increased activities of SOD and GSH-Px. Naringin can also improve neuronal innsulin signaling, brain mitochondrial function, and cognitive function in high-fat diet-induced obese mice.
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT01423019	Weight Loss	Not Applicable	Completed	-	United States, Texas ... more >> Integrative Health Technologies, Inc. San Antonio, Texas, United States, 78209 Collapse <<
NCT03582553	Safety Issues ... more >> Pharmacokinetics Collapse <<	Early Phase 1	Completed	-	United States, Louisiana ... more >> Pennington Biomedical Research Center Baton Rouge, Louisiana, United States, 70808 Collapse <<
NCT01272167	Post-menopausal Status	Not Applicable	Completed	-	France ... more >> CHU Clermont-Ferrand Clermont-Ferrand, France, 63003 Collapse <<

参考文献

[1] Shin W, Kim SJ, et al. Structure-taste correlations in sweet dihydrochalcone, sweet dihydroisocoumarin, and bitter flavone compounds. J Med Chem. 1995 Oct 13;38(21):4325-31.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 1.7166 mL
- 8.5829 mL
- 17.1659 mL
- 5 mM
- 0.3433 mL
- 1.7166 mL
- 3.4332 mL
- 10 mM
- 0.1717 mL
- 0.8583 mL
- 1.7166 mL

技术信息

CAS号

18916-17-1

储存条件

粉末: Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C27H34O14

运输

蓝冰

分子量

582.55

别名

Naringin DC;Naringin dihydrochalcone;柚皮苷二氢查尔酮;柚皮甙二氢查尔酮

溶解度

DMSO	98.0 mg/mL (168.2 mM)
Water	Insoluble
Ethanol	100.0 mg/mL (171.7 mM)

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Naringin dihydrochalcone/柚皮苷二氢查尔酮 Catalog No. CSN16184

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