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CAS No.: 23720-80-1

Nardosinone/苷松新酮 Catalog No. CSN19880

Synonyms: 甘松新酮

Nardosinone was isolated as an enhancer of nerve growth factor (NGF) from Nardostachys chinensis. Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner, suggesting that Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway.

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描述Nardosinone was isolated as an enhancer of nerve growth factor (NGF) from Nardostachys chinensis. Nardosinone (0.1-100 microM) enhanced dibutyryl cyclic AMP (dbcAMP, 0.3 mM)- and staurosporine (10 nM)-induced neurite outgrowth from PC12D cells in a concentration-dependent manner. Nardosinone enhances a downstream step of MAP kinase in the MAP kinase-dependent signaling pathway^[3]. Nardosinone may reduce the motor and cognitive symptoms in the animal PD model by regulating DRD2 (Dopamine receptor D2) expression^[4]. Pretreatment with nardosinone (25, 50, 100, and 200 μmol/L) could significantly inhibit the enlargement of cell surface area induced by AngII. The protective effects of nardosinone might be mediated by repressing the phosphorylation of related proteins in PI3K/Akt and MEK/ERK signaling pathways^[5]. Nardosinone promotes cells proliferation and increases cells migration distance in a dose-dependent manner. Nardosinone also induces the selective differentiation of neural stem cells to neurons and oligodendrocytes, as indicated by the expression of microtubule-associated protein-2 and myelin basic protein, respectively. Nardosinone also increases the expression of phospho-extracellular signal-regulated kinase and phospho-cAMP response element binding protein during proliferation and differentiation^[6].
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实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 3.9947 mL
- 19.9734 mL
- 39.9467 mL
- 5 mM
- 0.7989 mL
- 3.9947 mL
- 7.9893 mL
- 10 mM
- 0.3995 mL
- 1.9973 mL
- 3.9947 mL

技术信息

CAS号	23720-80-1	储存条件	粉末 Sealed in dry,Store in freezer, under -20°C 液体 -20°C:3-6 月 -80°C:12月
分子式	C15H22O3	运输	蓝冰
分子量	250.33	别名	甘松新酮

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