|2-(萘-1-基甲基)-4,5-二氢-1H-咪唑盐酸盐|CsnPharm

CAS No.: 550-99-2

Naphazoline HCl/盐酸萘甲唑啉 Catalog No. CSN11521

Synonyms: Naphthazoline hydrochloride;Naphazoline (hydrochloride);2-(1-Naphthylmethyl)-2-imidazoline

Naphazoline HCl is a direct-acting sympathomimetic amine with vasoconstrictive activity.

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靶点选择性

生物活性

实验方案

技术信息

生物活性

描述Naphazoline Hydrochloride (pKa = 10.8) is a sympathomimetric agent with marked α-adrenergic activity and is a relatively long-lasting vasoconstrictor with a rapid action in reducing swelling when applied to the mucous membrane^[2]. Because both the kidney and liver express α2-adrenergic receptors, their failure was likely associated with naphazoline overdose-induced hypoperfusion^[3]. In addition to producing ocular hypotension, topical application of naphazoline (75 mg; 25 ml) caused significant reduction, from 2.8 to 1.5 ml/min, in aqueous humor flow^[4].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT03490682	Pregnancy Hea... more >>lthy Volunteers Parturition Collapse <<	Not Applicable	Recruiting	May 17, 2020	France ... more >> Hospices Civils de Lyon Recruiting Bron, France, 69500 Contact: Lionel BOUVET, MD 4 72 12 97 63 ext +33 lionel.bouvet@chu-lyon.fr Principal Investigator: Lionel BOUVET, MD Collapse <<
NCT00536367	-	-	Completed	-	United States, Ohio ... more >> The Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse <<
NCT03324113	Neoplasm Malignant	Phase 1	Active, not recruiting	January 2019	Japan ... more >> Investigational Site Number 3920003 Kashiwa-Shi, Japan Investigational Site Number 3920002 Nagoya-Shi, Japan Investigational Site Number 3920001 Sunto-Gun, Japan Collapse <<

更多
参考文献

[1] Zavala JA, Pereira ER, et al. Hemorrhagic stroke after naphazoline exposition: case report. Arq Neuropsiquiatr. 2004 Sep;62(3B):889-91.
[2] Huang T, Chen N, Wang D, Lai Y, Cao Z. A validated stability-indicating HPLC method for the simultaneous determination of pheniramine maleate and naphazoline hydrochloride in pharmaceutical formulations. Chem Cent J. 2014 Feb 1;8(1):7. doi: 10.1186/1752-153X-8-7.
[3] Ono Y, Ono N, Shinohara K. Tissue Hypoperfusion, Hypercoagulopathy, and Kidney and Liver Dysfunction after Ingestion of a Naphazoline-Containing Antiseptic. Case Rep Emerg Med. 2017;2017:3968045.
[4] Ogidigben MJ, Chu TC, Potter DE. Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors. Exp Eye Res. 2001 Mar;72(3):331-9.

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 4.0529 mL
- 20.2646 mL
- 40.5293 mL
- 5 mM
- 0.8106 mL
- 4.0529 mL
- 8.1059 mL
- 10 mM
- 0.4053 mL
- 2.0265 mL
- 4.0529 mL

技术信息

CAS号

550-99-2

储存条件

粉末: Keep in dark place,Inert atmosphere,Room temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C14H15ClN2

运输

蓝冰

分子量

246.74

别名

Naphthazoline hydrochloride;Naphazoline (hydrochloride);2-(1-Naphthylmethyl)-2-imidazoline;Albalon Liquifilm;Nafazair;Naphazoline HCl;Rhinantin;Vasocon;盐酸萘甲唑啉

溶解度

DMSO	40.0 mg/mL (162.1 mM)
Water	50.0 mg/mL (202.6 mM)

动物实验配方

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NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT03490682	Pregnancy Hea... more >>lthy Volunteers Parturition Collapse <<	Not Applicable	Recruiting	May 17, 2020	France ... more >> Hospices Civils de Lyon Recruiting Bron, France, 69500 Contact: Lionel BOUVET, MD 4 72 12 97 63 ext +33 lionel.bouvet@chu-lyon.fr Principal Investigator: Lionel BOUVET, MD Collapse <<
NCT00536367	-	-	Completed	-	United States, Ohio ... more >> The Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse <<
NCT03324113	Neoplasm Malignant	Phase 1	Active, not recruiting	January 2019	Japan ... more >> Investigational Site Number 3920003 Kashiwa-Shi, Japan Investigational Site Number 3920002 Nagoya-Shi, Japan Investigational Site Number 3920001 Sunto-Gun, Japan Collapse <<
NCT03077308	-	-	Recruiting	July 31, 2019	United States, Colorado ... more >> University of Colorado Denver Recruiting Denver, Colorado, United States, 80045-2571 Contact: Gina VanderVeen 720-777-5514 Gina.VanderVeen@childrenscolorado.org Principal Investigator: Tim Benke, MD, PhD United States, Massachusetts Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115-5724 Contact: Mustafa Sahin, MD, PhD 617-355-8994 mustafa.sahin@childrens.harvard.edu Contact: Lindsay Swanson 617-355-8994 lindsay.swanson@childrens.harvard.edu United States, New York University of Rochester Recruiting Rochester, New York, United States, 14627-0140 Contact: To be named Principal Investigator: Alex Paciorkowski, MD, PhD Sub-Investigator: Laurie Seltzer, MD United States, Ohio Cincinnati Children's Hospital Recruiting Cincinnati, Ohio, United States, 45229 Contact: Max Mays 513-803-7935 Maxwell.Mays@cchmc.org Principal Investigator: Shannon Standridge, DO United States, Pennsylvania Children's Hospital of Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 19104-4318 Contact: Casey Gorman 267-426-5171 GormanC@email.chop.edu Principal Investigator: Eric Marsh, MD, PhD United States, Tennessee Vanderbilt University Recruiting Nashville, Tennessee, United States, 37212 Contact: Nicole Thompson 615-343-4586 Nicole.i.thompson@vanderbilt.edu Principal Investigator: Sar Peters, PhD Sub-Investigator: Cary Fu, MD Collapse <<
NCT02601235	Nasal Congestion	Phase 3	Recruiting	September 2018	Brazil ... more >> Faculdade de Medicina do ABC Recruiting Santo André, SP, Brazil Principal Investigator: Neusa Wandalsen, MD Collapse <<
NCT00489398	Allergic Conjunctivitis	Phase 4	Withdrawn(Protocol changes)	December 2008	-
NCT00584662	Chronic Rhinitis	Not Applicable	Terminated	-	United States, Florida ... more >> USF Tampa, Florida, United States, 33613 Collapse <<
NCT00769886	Allergic Conjunctivitis	Phase 3	Completed	-	United States, Massachusetts ... more >> Ophthalmic Research Consultants, Inc. North Andover, Massachusetts, United States, 01845 Collapse <<
NCT00770133	Allergic Conjunctivitis	Phase 3	Completed	-	United States, Massachusetts ... more >> Ophthalmic Research Consultants, Inc. North Andover, Massachusetts, United States, 01845 Collapse <<
NCT01390961	Allergic Conjunctivitis	Phase 4	Unknown	January 2012	United States, California ... more >> Milton M. Hom, OD, FAAO. Azusa, California, United States, 91702 Collapse <<
NCT01533220	Flu Cold ... more >> Allergic Disorder of Respiratory System Collapse <<	Phase 3	Unknown	December 2013	Brazil ... more >> Instituto Paranaense de Otorrinolaringologia Curitiba, Parana, Brazil, 80620010 Collapse <<
NCT02433080	Endometrial Neoplasms	Phase 2	Completed	-	United Kingdom ... more >> Barts Health NHS Trust London, Greater London, United Kingdom, E1 1BB University College London Hospital NHS Trust London, Greater London, United Kingdom, NW1 3AD Collapse <<
NCT03077308	-	-	Recruiting	July 31, 2019	United States, Colorado ... more >> University of Colorado Denver Recruiting Denver, Colorado, United States, 80045-2571 Contact: Gina VanderVeen 720-777-5514 Gina.VanderVeen@childrenscolorado.org Principal Investigator: Tim Benke, MD, PhD United States, Massachusetts Boston Children's Hospital Recruiting Boston, Massachusetts, United States, 02115-5724 Contact: Mustafa Sahin, MD, PhD 617-355-8994 mustafa.sahin@childrens.harvard.edu Contact: Lindsay Swanson 617-355-8994 lindsay.swanson@childrens.harvard.edu United States, New York University of Rochester Recruiting Rochester, New York, United States, 14627-0140 Contact: To be named Principal Investigator: Alex Paciorkowski, MD, PhD Sub-Investigator: Laurie Seltzer, MD United States, Ohio Cincinnati Children's Hospital Recruiting Cincinnati, Ohio, United States, 45229 Contact: Max Mays 513-803-7935 Maxwell.Mays@cchmc.org Principal Investigator: Shannon Standridge, DO United States, Pennsylvania Children's Hospital of Philadelphia Recruiting Philadelphia, Pennsylvania, United States, 19104-4318 Contact: Casey Gorman 267-426-5171 GormanC@email.chop.edu Principal Investigator: Eric Marsh, MD, PhD United States, Tennessee Vanderbilt University Recruiting Nashville, Tennessee, United States, 37212 Contact: Nicole Thompson 615-343-4586 Nicole.i.thompson@vanderbilt.edu Principal Investigator: Sar Peters, PhD Sub-Investigator: Cary Fu, MD Collapse <<
NCT02433080	Endometrial Neoplasms	Phase 2	Completed	-	United Kingdom ... more >> Barts Health NHS Trust London, Greater London, United Kingdom, E1 1BB University College London Hospital NHS Trust London, Greater London, United Kingdom, NW1 3AD Collapse <<
NCT03490682	Pregnancy Hea... more >>lthy Volunteers Parturition Collapse <<	Not Applicable	Recruiting	May 17, 2020	France ... more >> Hospices Civils de Lyon Recruiting Bron, France, 69500 Contact: Lionel BOUVET, MD 4 72 12 97 63 ext +33 lionel.bouvet@chu-lyon.fr Principal Investigator: Lionel BOUVET, MD Collapse <<
NCT02601235	Nasal Congestion	Phase 3	Recruiting	September 2018	Brazil ... more >> Faculdade de Medicina do ABC Recruiting Santo André, SP, Brazil Principal Investigator: Neusa Wandalsen, MD Collapse <<
NCT03324113	Neoplasm Malignant	Phase 1	Active, not recruiting	January 2019	Japan ... more >> Investigational Site Number 3920003 Kashiwa-Shi, Japan Investigational Site Number 3920002 Nagoya-Shi, Japan Investigational Site Number 3920001 Sunto-Gun, Japan Collapse <<
NCT00536367	-	-	Completed	-	United States, Ohio ... more >> The Ohio State University Medical Center Columbus, Ohio, United States, 43210 Collapse <<
NCT00489398	Allergic Conjunctivitis	Phase 4	Withdrawn(Protocol changes)	December 2008	-
NCT00769886	Allergic Conjunctivitis	Phase 3	Completed	-	United States, Massachusetts ... more >> Ophthalmic Research Consultants, Inc. North Andover, Massachusetts, United States, 01845 Collapse <<
NCT01533220	Flu Cold ... more >> Allergic Disorder of Respiratory System Collapse <<	Phase 3	Unknown	December 2013	Brazil ... more >> Instituto Paranaense de Otorrinolaringologia Curitiba, Parana, Brazil, 80620010 Collapse <<
NCT00584662	Chronic Rhinitis	Not Applicable	Terminated	-	United States, Florida ... more >> USF Tampa, Florida, United States, 33613 Collapse <<
NCT01390961	Allergic Conjunctivitis	Phase 4	Unknown	January 2012	United States, California ... more >> Milton M. Hom, OD, FAAO. Azusa, California, United States, 91702 Collapse <<
NCT00770133	Allergic Conjunctivitis	Phase 3	Completed	-	United States, Massachusetts ... more >> Ophthalmic Research Consultants, Inc. North Andover, Massachusetts, United States, 01845 Collapse <<

Naphazoline HCl/盐酸萘甲唑啉 Catalog No. CSN11521

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