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CAS No.: 57149-08-3

Naftopidil 2HCl/盐酸萘哌地尔 Catalog No. CSN11513

Synonyms: KT-611;KT-611 2HCl;Naftopidil dihydrochloride

Naftopidil 2HCl is a selective α1-adrenergic receptor antagonist or α blocker used for treatment for lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH).

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纯度 & 质量文件批次:

靶点选择性

生物活性

实验方案

技术信息

生物活性

靶点 5-HT Receptor 1A

IC50:0.1μM Adrenergic Receptor α1

IC50:0.2μM
描述Naftopidil (Dihydrochloride), a selective α1-adrenergic receptor antagonist or alpha blocker, is an antihypertensive drug. Naftopidil significantly improved the overall international prostatic symptom score^[3]. The intravenous administration of each of Naftopidil dose-dependently inhibited phenylephrine-induced increases in prostatic pressure and mean blood pressure, the selectivity index was 3.76 ^[4]. Moreover, Naftopidil induces apoptosis and autophagy of HGC27 cells (human gastric cancer cell line), however, autophagy is considered to inhibit apoptosis^[5].
参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1486 mL
- 10.7432 mL
- 21.4863 mL
- 5 mM
- 0.4297 mL
- 2.1486 mL
- 4.2973 mL
- 10 mM
- 0.2149 mL
- 1.0743 mL
- 2.1486 mL

技术信息

CAS号

57149-08-3

储存条件

粉末: Sealed in dry,Room Temperature

液体: -20°C:3-6 月 -80°C:12月

分子式

C24H30Cl2N2O3

运输

蓝冰

分子量

465.41

别名

KT-611;KT-611 2HCl;Naftopidil dihydrochloride;Naftopidil 2HCl;KT-611 dihydrochloride;BM-15275 dihydrochloride

溶解度

DMSO	40.0 mg/mL (85.9 mM)
Water	Insoluble
Ethanol	2.0 mg/mL (4.3 mM)

动物实验配方

0.5% CMC+water

30 mg/mL

suspension

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靶点	Description	IC50
5-HT Receptor 1A		IC50:0.1μM
Adrenergic Receptor α1		IC50:0.2μM

Naftopidil 2HCl/盐酸萘哌地尔 Catalog No. CSN11513

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