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CAS No.: 414864-00-9
Synonyms: NSC726630;PX-105684;PXD101
Belinostat is a HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors.
生物活性
靶点 | HDAC IC50:27nM |
实验方案
技术信息
CAS号 | 414864-00-9 | 储存条件 |
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分子式 | C15H14N2O4S | 运输 | 蓝冰 | |||||||||||||
分子量 | 318.35 | 别名 | NSC726630;PX-105684;PXD101 | |||||||||||||
溶解度 |
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动物实验配方 |
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Cell Lines | Concentration | Assay Type | Time | Activity Description | Data Sources |
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AsPc1 | - | Growth Inhibition Assay | 48 h | EC50=0.3 μM | 23475695 |
AsPc1 | 1/10 μM | Function Assay | 24 h | induces growth arrested in G2/M | 23475695 |
AsPC-1 | 0-800 nM | Growth Inhibition Assay | 48 h | inhibits cell proliferation in a dose dependent manner | 22681698 |
AsPC-1 | 100/500/1000 nM | Apoptosis Assay | 48 h | induces dose dependent apoptosis | 22681698 |
BxPc3 | - | Growth Inhibition Assay | 48 h | EC50=1.0 μM | 23475695 |
Granta-519 | - | Growth Inhibition Assay | 24 h | IC50=56.3 μM | 20068080 |
H1299 | - | Growth Inhibition Assay | 72 h | IC50=1.2 μM | 23515752 |
H1650 | - | Growth Inhibition Assay | 72 h | IC50=0.88 μM | 23515752 |
H1650 | 500 nM | Function Assay | 24 h | decreases EGFR expression | 23515752 |
H1650 | 0.5/1/2 μM | Function Assay | 4 h | inhibits the levels of Akt (p-Akt) and EGFR | 23515752 |
H1666 | - | Growth Inhibition Assay | 72 h | IC50>10 μM | 23515752 |
H1975 | - | Growth Inhibition Assay | 72 h | IC50=0.68 μM | 23515752 |
H460 | - | Growth Inhibition Assay | 72 h | IC50=0.86 μM | 23515752 |
H460 | 500 nM | Function Assay | 24 h | decreases EGFR expression | 23515752 |
H460 | 0.5/1/2 μM | Function Assay | 4 h | inhibits the levels of Akt (p-Akt) and EGFR | 23515752 |
H520 | - | Growth Inhibition Assay | 72 h | IC50=0.75 μM | 23515752 |
H820 | - | Growth Inhibition Assay | 72 h | IC50=0.4 μM | 23515752 |
HBL-2 | - | Growth Inhibition Assay | 24 h | IC50=0.4 μM | 20068080 |
HCC2279 | - | Growth Inhibition Assay | 72 h | IC50=0.4 μM | 23515752 |
HCC2935 | - | Growth Inhibition Assay | 72 h | IC50=0.97 μM | 23515752 |
HCC4006 | - | Growth Inhibition Assay | 72 h | IC50=0.46 μM | 23515752 |
HCC827 | - | Growth Inhibition Assay | 72 h | IC50=0.29 μM | 23515752 |
HCT116 | - | Growth Inhibition Assay | 48 h | EC50=0.28 μM | 17124594 |
HCT116 | 0.9 μM | Function Assay | 24 h | down-regulats TS protein levels after 6 h incubation | 17124594 |
HL-60 | 0.2/2 μM | Cell Viability Assay | 24/48/72 h | decreases cell viability in both time and dose dependent manner | 25864732 |
HL-60 | 2 μM | Function Assay | 24/48 h | blocks cell cycle in S phase | 25864732 |
HL-60 | 0.2 μM | Function Assay | 24/48/72 h | enhances RA-induced granulocytic differentiation | 25864732 |
Jeko-1 | - | Growth Inhibition Assay | 24 h | IC50=0.2 μM | 20068080 |
MiaPaCa2 | - | Growth Inhibition Assay | 48 h | EC50=0.7 μM | 23475695 |
MiaPaCa2 | 1/10 μM | Function Assay | 24 h | induces growth arrested in G2/M | 23475695 |
NB4 | 0.2/2 μM | Cell Viability Assay | 24/48/72 h | decreases cell viability in both time and dose dependent manner | 25864732 |
NB4 | 2 μM | Function Assay | 24/48 h | blocks cell cycle in S phase | 25864732 |
NB4 | 0.2 μM | Function Assay | 24/48/72 h | enhances RA-induced granulocytic differentiation | 25864732 |
Panc0203 | - | Growth Inhibition Assay | 48 h | EC50=22.2 μM | 23475695 |
Panc0327 | - | Growth Inhibition Assay | 48 h | EC50=0.5 μM | 23475695 |
Panc0327 | 1 μM | Apoptosis Assay | 24 h | induces apoptosis | 23475695 |
Panc0403 | - | Growth Inhibition Assay | 48 h | EC50=1.1 μM | 23475695 |
Panc0403 | 1 μM | Apoptosis Assay | 24 h | induces apoptosis | 23475695 |
PANC-1 | 10 μM | Function Assay | 2/4/6 h | induces AMPK activation | 23743198 |
PANC-1 | 1/10 μM | Cell Viability Assay | 48 h | decreases cell viability in a dose dependent manner | 23743198 |
PANC-1 | 10 μM | Function Assay | 2/4 h | increases intracellular ROS level | 23743198 |
Panc-1 | 0-800 nM | Growth Inhibition Assay | 48 h | inhibits cell proliferation in a dose dependent manner | 22681698 |
Panc-1 | 100/500/1000 nM | Apoptosis Assay | 48 h | induces dose dependent apoptosis | 22681698 |
Panc1005 | - | Growth Inhibition Assay | 48 h | EC50=1.1 μM | 23475695 |
Panc1005 | 1 μM | Apoptosis Assay | 24 h | induces apoptosis | 23475695 |
PC9 | - | Growth Inhibition Assay | 72 h | IC50=0.29 μM | 23515752 |
PC9 | 500 nM | Function Assay | 24 h | decreases EGFR expression | 23515752 |
PC9 | 0.5/1/2 μM | Function Assay | 4 h | inhibits the levels of Akt (p-Akt) and EGFR | 23515752 |
PL45 | - | Growth Inhibition Assay | 48 h | EC50=20.8 μM | 23475695 |
T3M4 | 0-800 nM | Growth Inhibition Assay | 48 h | inhibits cell proliferation in a dose dependent manner | 22681698 |
T3M4 | 100/500/1000 nM | Apoptosis Assay | 48 h | induces dose dependent apoptosis | 22681698 |
靶点 | Description | IC50 |
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HDAC | IC50:27nM |
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